在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDC14A Antibody

  • 中文名稱:
    CDC14A兔多克隆抗體
  • 貨號:
    CSB-PA154120
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells, using CC14A antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CDC14A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from Internal of Human CC14A.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.
  • 基因功能參考文獻:
    1. Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. Authors therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy. PMID: 28465438
    2. Mutations in CDC14A gene are associated with Autosomal-Recessive Severe to Profound Deafness. PMID: 27259055
    3. Overexpressed miR-301a may increase CDC14A expression and promote cell proliferation and migration in osteosarcomacells. Therefore, miR- 301a may be useful for osteosarcoma diagnosis and therapy. PMID: 27323075
    4. hCDC14A is down-regulated in many tumor tissues and reduced hCDC14A expression is correlated with poorer survival of patients with cancer PMID: 26747605
    5. These findings indicated that ZIPK may also be involved in the regulation of the cell cycle in human cells, by interacting with HsCdc14A. PMID: 25503649
    6. hCdc14A might be involved in cell cycle regulation in cultured human brain vascular endothelial cells during high glucose-, free fatty acids-, and hypoxia-induced injury. PMID: 25463242
    7. Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes. PMID: 21233601
    8. Cdc14A phosphatase prevents premature activation of Cdk1 regulating Cdc25A and Cdc25B at the entry into mitosis. PMID: 20956543
    9. human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14A are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation. PMID: 20479464
    10. human Cdc14A phosphatase disrupts centrosome separation PMID: 11901424
    11. Data suggest that hCdc14A phosphatase plays a role in the regulation of the centrosome cycle, mitosis, and cytokinesis, thereby influencing chromosome partitioning and genomic stability in human cells. PMID: 12134069
    12. analysis of iron-responsive elements in the 3'UTR of CDC14a protein PMID: 16760464
    13. hCdc14A is differentially expressed in human cancer cells and can interact with both p53 and the Cdk1/cyclin B complex; it may play a role in carcinogenesis PMID: 16784539
    14. Cdc14A may be involved in the cell cycle regulation of Cdc25A stability. PMID: 17172867
    15. RN-tre phosphorylation is critical for efficient hCdc14A association PMID: 17371873
    16. PLK1-HsCdc14A interaction provides a temporal regulation of HsCdc14A in chromosome segregation during mitosis. PMID: 17623655
    17. Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. PMID: 18235225

    顯示更多

    收起更多

  • 相關疾病:
    Deafness, autosomal recessive, 105 (DFNB105)
  • 亞細胞定位:
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Cell projection, kinocilium. Cell projection, stereocilium.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class CDC14 subfamily
  • 數據庫鏈接:

    HGNC: 1718

    OMIM: 603504

    KEGG: hsa:8556

    STRING: 9606.ENSP00000354916

    UniGene: Hs.127411



主站蜘蛛池模板: 久久久久影院美女国产主播| 国产成人无码18禁午夜福利p| 久久国产avjust麻豆| 午夜性色福利在线观看视频| 久久人人做人人爽人人av| 精品亚洲成a人无码成a在线观看| 熟妇女人妻丰满少妇中文字幕| 国产a国产片国产| 中文字幕丰满伦子无码| 免费福利视频一区二区三区高清| 肉色超薄丝袜脚交一区二区| 少女韩国电视剧在线观看完整| 日韩 国产 变态另类 欧美| 亚洲国产成人精品无码区宅男| 内射白嫩少妇超碰| 十八岁以下禁止观看黄下载链接| 色婷婷六月亚洲婷婷丁香| 成 人 网 站不卡在线观看| 国产欧美日韩一区二区三区| 日产一区日产2区| 天天爽夜夜爽人人爽从早干到睌 | 最近日本精品一卡2卡3卡4卡| 中国极品少妇videossexhd| 久久777国产线看观看精品| 51被公侵犯玩弄漂亮人妻| 亚洲人成电影在线天堂色| 无码一区二区三区视频| 日本大片免a费观看视频三区| 欧美乱码伦视频免费| 免费观看日本污污ww网站| 久久伊人蜜桃av一区二区| 老熟女毛茸茸浓毛| 又黄又硬又湿又刺激视频免费 | 久久久亚洲欧洲日产无码av| 日本免费一区二区三区| 美女黄18以下禁止观看| 国产av一区二区精品凹凸| 狠狠亚洲狠狠欧洲2019| 午夜福利理论片在线观看| 日韩精品久久久肉伦网站| 久久国产精品日本波多野结衣|