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  4. CD96 Antibody

CD96 Antibody

  • 中文名稱：
    CD96兔多克隆抗體
  • 貨號：
    CSB-PA004971LA01HU
  • 規(guī)格：
    ￥880
  • 圖片：
    • Western Blot
      Positive WB detected in: MCF7 whole cell lysate(20μg), 293 whole cell lysate(20μg), JK whole cell lysate(20μg), K562 whole cell lysate(20μg), Hela whole cell lysate(20μg)
      All lanes: CD96 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 66,100-200kd kDa
      Observed band size: 100 kDa
      Exposure time: 60s
    • Immunofluorescence staining of HepG2 cell with CSB-PA004971LA01HU at 1:110, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Immunofluorescence staining of HepG2 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品描述：

    The CD96 antibody production starts by inoculating a synthetic peptide corresponding to the 306-395 amino acids of the recombinant human T-cell surface protein tactile into a rabbit to induce an immune reaction. The resulting CD96 polyclonal antibody mixture is then subjected to protein G affinity chromatography purification. Its purity exceeds 95%. The purified CD96 antibody is finally tested for specificity and affinity in ELISA, WB, IHC, and IF applications, ensuring its ability to bind to the CD96 protein. It only reacts with human samples.

    The CD96 protein, also known as T-cell surface protein tactile, modulates immune cell activation and regulation by interacting with its ligand, CD155. CD96 has also been implicated in the regulation of immune checkpoint pathways, such as the programmed cell death protein 1 (PD-1) pathway.

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CD96 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD96; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD antigen CD96
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human T-cell surface protein tactile protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CD96 Antibody (CSB-PA004971LA01HU)，的標記方式是Non-conjugated。對于CD96 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA004971LB01HU CD96 Antibody, HRP conjugated ELISA
    FITC CSB-PA004971LC01HU CD96 Antibody, FITC conjugated
    Biotin CSB-PA004971LD01HU CD96 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen?affinity?purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
  • 基因功能參考文獻：
    1. Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID: 29531070
    2. Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID: 27620276
    3. CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID: 26642704
    4. In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID: 24751333
    5. down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID: 23272144
    6. CD96 could serve as a target structure for effector cell-mediated lysis. PMID: 22879978
    7. The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID: 21729528
    8. CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID: 15034010
    9. CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID: 17576927
    10. CD96-driven adhesion to CD155 may be crucial in developmental processes PMID: 19056733

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  • 相關疾病：
    C syndrome (CSYN)
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16892

    OMIM: 211750

    KEGG: hsa:10225

    STRING: 9606.ENSP00000283285

    UniGene: Hs.142023



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