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  4. Human T-cell surface protein tactile(CD96) ELISA kit

Human T-cell surface protein tactile(CD96) ELISA kit

  • 中文名稱：
    人T細(xì)胞表面觸覺蛋白(CD96)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL004971HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人T細(xì)胞表面觸覺蛋白(CD96)酶聯(lián)免疫試劑盒（CSB-EL004971HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的CD96含量。CD96是一種重要靶點(diǎn)。它屬于免疫檢查點(diǎn)分子，在腫瘤免疫逃逸等方面有潛在作用。研究機(jī)制上，其與配體結(jié)合后會(huì)影響免疫細(xì)胞活性，干擾免疫信號(hào)傳導(dǎo)，目前針對(duì)CD96開展的研究有望為腫瘤免疫治療開辟新方向。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，適用于體外實(shí)驗(yàn)中對(duì)CD96蛋白表達(dá)的動(dòng)態(tài)監(jiān)測，例如腫瘤微環(huán)境研究、免疫細(xì)胞功能評(píng)估或抗體藥物作用機(jī)制探索等領(lǐng)域。本試劑盒為研究CD96在免疫調(diào)控網(wǎng)絡(luò)中的功能及其與疾病關(guān)聯(lián)性提供了可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    CD96; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD antigen CD96
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CD96 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 93
    Range % 89-97
    1:2 Average % 96
    Range % 92-100
    1:4 Average % 104
    Range % 100-112
    1:8 Average % 94
    Range % 90-100
  • 回收率：
    The recovery of human CD96 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 89 84-93
    EDTA plasma (n=4) 93 88-97
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    10 2.045 1.972 2.009 1.836
    5 1.502 1.581 1.542 1.369
    2.5 1.104 1.054 1.079 0.906
    1.25 0.711 0.727 0.719 0.546
    0.625 0.510 0.505 0.508 0.335
    0.312 0.361 0.349 0.355 0.182
    0.156 0.294 0.286 0.290 0.117
    0 0.175 0.170 0.173 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
  • 基因功能參考文獻(xiàn)：
    1. Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID: 29531070
    2. Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID: 27620276
    3. CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID: 26642704
    4. In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID: 24751333
    5. down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID: 23272144
    6. CD96 could serve as a target structure for effector cell-mediated lysis. PMID: 22879978
    7. The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID: 21729528
    8. CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID: 15034010
    9. CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID: 17576927
    10. CD96-driven adhesion to CD155 may be crucial in developmental processes PMID: 19056733

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  • 相關(guān)疾病：
    C syndrome (CSYN)
  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16892

    OMIM: 211750

    KEGG: hsa:10225

    STRING: 9606.ENSP00000283285

    UniGene: Hs.142023



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