在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CD84 Antibody

  • 中文名稱:
    CD84兔多克隆抗體
  • 貨號:
    CSB-PA004964GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CD_antigen=CD84 antibody; CD84 antibody; CD84 antigen antibody; CD84 molecule antibody; CDw84 antibody; Cell surface antigen MAX.3 antibody; hCD84 antibody; Hly9 beta antibody; Hly9-beta antibody; Leucocyte differentiation antigen CD84 antibody; Leukocyte Antigen antibody; Leukocyte antigen CD84 antibody; Leukocyte differentiation antigen antibody; Leukocyte differentiation antigen CD84 antibody; LY9B antibody; mCD84 antibody; Signaling lymphocytic activation molecule 5 antibody; SLAF5_HUMAN antibody; SLAM family member 5 antibody; SLAMF5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human CD84
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity. In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1. In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2. Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8.
  • 基因功能參考文獻:
    1. Results show that CD84 expressed on CLL cells interact with CD84 expressed on cells in their microenvironment, inducing cell survival in both sides. PMID: 27452524
    2. up-regulated in Kawasaki disease arteriopathy PMID: 24635044
    3. data show that overexpression of CD84 in CLL is an important survival mechanism that appears to be an early event in the pathogenesis of the disease PMID: 23435417
    4. These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry PMID: 23555300
    5. CD84 is highly expressed in mast cells and that it contributes to the regulation of FcepsilonRI signaling PMID: 22068234
    6. CD84 enhances proliferation of human activated T cells by a Src homology 2 domain-containing cytoplasmic adaptor protein SLAM-associated protein (SAP)-independent mechanism. PMID: 12928397
    7. The structure of CD84 provides insight into SLAM family function. Point mutations were studied. PMID: 17563375
    8. These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells. PMID: 18243321

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast
  • 數據庫鏈接:

    HGNC: 1704

    OMIM: 604513

    KEGG: hsa:8832

    STRING: 9606.ENSP00000312367

    UniGene: Hs.398093



主站蜘蛛池模板: 亚洲精品国产av成拍色拍婷婷| 成年女人毛片免费观看97| av免费网站在线观看| 怡红院a∨人人爰人人爽| 又大又黄又粗又爽的免费视频| 欧美 国产日韩 综合在线| 国产精品一区二区av| 亚州中文字幕无码中文字幕| 日韩免费一区二区三区高清| 国产日韩欧美不卡在线二区| 草的我好爽视频| 国产精品无码不卡一区二区三区| av片在线观看免费| 国产成人亚洲高清一区| 一本无码中文字幕在线观| 欧美乱码卡一卡二卡四卡免费| 欧美拍拍视频免费大全| 久久综合色之久久综合| 亚洲成年网站青青草原| 国产ktv交换配乱婬视频| 99久久伊人精品综合观看| 免费无遮挡无码永久视频| 久久无码专区国产精品s| 国产产无码乱码精品久久鸭| 久久久久国产精品人妻aⅴ四季| 中本亚洲欧美国产日韩| 国产又粗又猛又爽又黄的视频在线观看动漫| 久久久久成人网站| 欧美大肥婆大肥bbbbb| 亚洲日韩性欧美中文字幕| 亚洲国产精品一区二区制服| 国产免费观看久久黄av片| 久久婷婷五月综合色一区二区| 国产乱码免费卡1卡二卡3| av无码中文字幕不卡一区二区三区| 欧美黑吊大战白妞| 搡老岳熟女国产熟妇| 99国产精品久久久蜜芽| 五月丁香六月综合缴情在线| 色欲国产麻豆一精品一av一免费| 亚洲熟妇无码乱子av电影|