在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CD84 Antibody

  • 中文名稱:
    CD84兔多克隆抗體
  • 貨號:
    CSB-PA004964GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CD_antigen=CD84 antibody; CD84 antibody; CD84 antigen antibody; CD84 molecule antibody; CDw84 antibody; Cell surface antigen MAX.3 antibody; hCD84 antibody; Hly9 beta antibody; Hly9-beta antibody; Leucocyte differentiation antigen CD84 antibody; Leukocyte Antigen antibody; Leukocyte antigen CD84 antibody; Leukocyte differentiation antigen antibody; Leukocyte differentiation antigen CD84 antibody; LY9B antibody; mCD84 antibody; Signaling lymphocytic activation molecule 5 antibody; SLAF5_HUMAN antibody; SLAM family member 5 antibody; SLAMF5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human CD84
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity. In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1. In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2. Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8.
  • 基因功能參考文獻:
    1. Results show that CD84 expressed on CLL cells interact with CD84 expressed on cells in their microenvironment, inducing cell survival in both sides. PMID: 27452524
    2. up-regulated in Kawasaki disease arteriopathy PMID: 24635044
    3. data show that overexpression of CD84 in CLL is an important survival mechanism that appears to be an early event in the pathogenesis of the disease PMID: 23435417
    4. These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry PMID: 23555300
    5. CD84 is highly expressed in mast cells and that it contributes to the regulation of FcepsilonRI signaling PMID: 22068234
    6. CD84 enhances proliferation of human activated T cells by a Src homology 2 domain-containing cytoplasmic adaptor protein SLAM-associated protein (SAP)-independent mechanism. PMID: 12928397
    7. The structure of CD84 provides insight into SLAM family function. Point mutations were studied. PMID: 17563375
    8. These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells. PMID: 18243321

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast
  • 數據庫鏈接:

    HGNC: 1704

    OMIM: 604513

    KEGG: hsa:8832

    STRING: 9606.ENSP00000312367

    UniGene: Hs.398093



主站蜘蛛池模板: 精品久久国产字幕高潮| 亚洲图片综合图区20p| 伊人久久大香线蕉av五月天宝贝| 欧美一进一出抽搐大尺度视频| 特级无码毛片免费视频尤物| 美女黄频视频大全免费的国内| 秋霞午夜一区二区三区黄瓜视频 | 中文字幕制服丝袜第57页| 欧美三级a做爰在线观看| 精品欧洲av无码一区二区三区| 日韩 国产 变态另类 欧美| 亚洲 日韩 国产 有码 不卡| 亚洲精品毛片一区二区三区| 国产精品久久久av久久久| 中文国产乱码在线人妻一区二区| 青青草国产免费国产是公开| 国产乱人伦中文无无码视频试看| 国产精品久久久久久久| 18禁黄网站禁片无遮挡观看| 50岁熟妇的呻吟声对白| 国产成人精品三级麻豆| 国产精品无码一区二区三区| 西西人体大胆无码视频| 日本中文一区二区三区亚洲| 男ji大巴进入女人的视频| 无码国产午夜福利片在线观看 | 亚洲熟女乱色综合亚洲图片| 亚洲6080yy久久无码产自国产 | 18禁无遮挡肉动漫在线播放观看| 人妻体验按摩到忍不住哀求继续| 国产成人一区二区三区影院动漫| 日韩理论午夜无码| 国产精品亚洲mnbav网站| 人妻熟女一区二区aⅴ千叶宁真| 亚洲小说区图片区另类春色| 丝袜老师高潮呻吟高潮| 精品无码一区二区三区的天堂| 久久久性色精品国产免费观看| 2019久久视频这里有精品15| 新香蕉少妇视频网站| 夜夜国产亚洲视频香蕉|