在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CD84 Antibody

  • 中文名稱:
    CD84兔多克隆抗體
  • 貨號:
    CSB-PA005235
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of K562 L929 cells using CD84 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CD_antigen=CD84 antibody; CD84 antibody; CD84 antigen antibody; CD84 molecule antibody; CDw84 antibody; Cell surface antigen MAX.3 antibody; hCD84 antibody; Hly9 beta antibody; Hly9-beta antibody; Leucocyte differentiation antigen CD84 antibody; Leukocyte Antigen antibody; Leukocyte antigen CD84 antibody; Leukocyte differentiation antigen antibody; Leukocyte differentiation antigen CD84 antibody; LY9B antibody; mCD84 antibody; Signaling lymphocytic activation molecule 5 antibody; SLAF5_HUMAN antibody; SLAM family member 5 antibody; SLAMF5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human CD84.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity. In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1. In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2. Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8.
  • 基因功能參考文獻:
    1. Results show that CD84 expressed on CLL cells interact with CD84 expressed on cells in their microenvironment, inducing cell survival in both sides. PMID: 27452524
    2. up-regulated in Kawasaki disease arteriopathy PMID: 24635044
    3. data show that overexpression of CD84 in CLL is an important survival mechanism that appears to be an early event in the pathogenesis of the disease PMID: 23435417
    4. These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry PMID: 23555300
    5. CD84 is highly expressed in mast cells and that it contributes to the regulation of FcepsilonRI signaling PMID: 22068234
    6. CD84 enhances proliferation of human activated T cells by a Src homology 2 domain-containing cytoplasmic adaptor protein SLAM-associated protein (SAP)-independent mechanism. PMID: 12928397
    7. The structure of CD84 provides insight into SLAM family function. Point mutations were studied. PMID: 17563375
    8. These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells. PMID: 18243321

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast
  • 數據庫鏈接:

    HGNC: 1704

    OMIM: 604513

    KEGG: hsa:8832

    STRING: 9606.ENSP00000312367

    UniGene: Hs.398093



主站蜘蛛池模板: 久久婷婷五月综合色欧美蜜芽| 成人天堂婷婷青青视频在线观看| 欧美三级不卡在线观看| 欧美乱大交av片久久123| 中国凸偷窥xxxx自由视频| 少妇裸体性生交| 亚洲欧美国产精品久久久久久久| 无码国模国产在线观看免费| 丰满少妇aaaaaa爰片毛片| 丰满熟妇人妻av无码区| 麻豆一区二区三区精品视频| 午夜美女裸体福利视频| √天堂资源中文| 少妇人妻av无码专区| 欧美牲交a欧美牲交aⅴ免费下载 | 亚洲色成人中文字幕网站| 国产男女无遮挡猛进猛出| 精品国产国语对白久久免费| 18禁成人黄网站免费观看久久| 日韩人妻无码一区二区三区| 国产乱子伦农村叉叉叉| 韩国的无码av看免费大片在线| 亚洲裸男gv网站| 亚洲妓女综合网99| 女人被狂c到高潮视频网站| 国产亚洲久久久久久久| 精品国产人妻一区二区三区 | 国产男女爽爽爽免费视频| 超碰曰口干天天种夜夜爽| 五十路熟妇强烈无码| 中国无码人妻丰满熟妇啪啪软件| 日本又色又爽又黄的a片吻戏| 2021国产精品香蕉在线观看| 少妇裸体性生交| 欧美丰满熟妇xxxxx| 国产开嫩苞实拍在线播放视频| 日本国产制服丝袜一区| 日本内射精品一区二区视频| 大j8黑人w巨大888a片| 亚洲成av人在线观看网站| 亚洲精品无码久久久久久|