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  4. CCT5 Antibody

CCT5 Antibody

  • 中文名稱：
    CCT5兔多克隆抗體
  • 貨號：
    CSB-PA008289
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HepG2 cells using TCP-1 ε Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CCT5
  • 別名：
    CCT 5 antibody; CCT epsilon antibody; CCT-epsilon antibody; CCT5 antibody; CCTE antibody; CCTepsilon antibody; Chaperonin containing T-complex polypeptide 1; subunit 5 antibody; Chaperonin containing TCP 1 epsilon antibody; Chaperonin containing TCP 1 subunit 5 antibody; Chaperonin containing TCP 1 subunit 5 epsilon antibody; Chaperonin containing TCP1 epsilon antibody; Chaperonin containing TCP1 subunit 5 antibody; Chaperonin containing TCP1 subunit 5 epsilon antibody; KIAA0098 antibody; T complex protein 1 epsilon subunit antibody; T complex protein 1 subunit epsilon antibody; T-complex protein 1 subunit epsilon antibody; TCP 1 epsilon antibody; TCP-1-epsilon antibody; TCP1epsilon antibody; TCPE antibody; TCPE_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TCP-1 ε.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
  • 基因功能參考文獻：
    1. CCT5 complex caps mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC chaperonin and the CCT5 complex PMID: 25995452
    2. H147R CCT5 was not as efficient in chaperoning these substrates as wild type CCT5. PMID: 25124038
    3. introduction of the truncated human CCT epsilon subunit into yeast cells PMID: 22232265
    4. A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia. PMID: 16399879
  • 相關疾病：
    Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    TCP-1 chaperonin family
  • 數據庫鏈接：

    HGNC: 1618

    OMIM: 256840

    KEGG: hsa:22948

    STRING: 9606.ENSP00000280326

    UniGene: Hs.1600



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