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Human T-complex protein 1 subunit epsilon(CCT5) ELISA kit

  • 中文名稱:
    人T復合物蛋白1亞基ε(CCT5)酶聯免疫試劑盒
  • 貨號:
    CSB-EL004862HU
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人T復合物蛋白1亞基ε(CCT5)酶聯免疫試劑盒(CSB-EL004862HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿,組織勻漿、細胞裂解物樣本中的CCT5含量。CCT5是一種重要靶點。它屬于分子伴侶蛋白家族,在細胞內參與眾多蛋白質的折疊過程。目前研究關注其在細胞內穩態維持和疾病發生發展中的作用機制,了解其與疾病的關聯,有望為相關疾病的治療提供新的靶點和策略。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL,適用于體外培養細胞模型、動物組織或液體樣本中CCT5表達水平的動態監測,為探索其在細胞增殖、凋亡調控或疾病模型中的功能提供定量分析工具,廣泛用于分子生物學、病理機制及藥物干預效果評估等基礎研究領域。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    CCT 5 ELISA Kit; CCT epsilon ELISA Kit; CCT-epsilon ELISA Kit; CCT5 ELISA Kit; CCTE ELISA Kit; CCTepsilon ELISA Kit; Chaperonin containing T-complex polypeptide 1; subunit 5 ELISA Kit; Chaperonin containing TCP 1 epsilon ELISA Kit; Chaperonin containing TCP 1 subunit 5 ELISA Kit; Chaperonin containing TCP 1 subunit 5 epsilon ELISA Kit; Chaperonin containing TCP1 epsilon ELISA Kit; Chaperonin containing TCP1 subunit 5 ELISA Kit; Chaperonin containing TCP1 subunit 5 epsilon ELISA Kit; KIAA0098 ELISA Kit; T complex protein 1 epsilon subunit ELISA Kit; T complex protein 1 subunit epsilon ELISA Kit; T-complex protein 1 subunit epsilon ELISA Kit; TCP 1 epsilon ELISA Kit; TCP-1-epsilon ELISA Kit; TCP1epsilon ELISA Kit; TCPE ELISA Kit; TCPE_HUMAN ELISA Kit
  • 縮寫:
    CCT5
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma,tissue homogenates, cell lysates
  • 檢測范圍:
    15.6 pg/mL-1000 pg/mL
  • 靈敏度:
    3.9 pg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Signal Transduction
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
  • 基因功能參考文獻:
    1. CCT5 complex caps mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC chaperonin and the CCT5 complex PMID: 25995452
    2. H147R CCT5 was not as efficient in chaperoning these substrates as wild type CCT5. PMID: 25124038
    3. introduction of the truncated human CCT epsilon subunit into yeast cells PMID: 22232265
    4. A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia. PMID: 16399879
  • 相關疾病:
    Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP)
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    TCP-1 chaperonin family
  • 數據庫鏈接:

    HGNC: 1618

    OMIM: 256840

    KEGG: hsa:22948

    STRING: 9606.ENSP00000280326

    UniGene: Hs.1600



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