在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CCNH Antibody

  • 中文名稱:
    CCNH兔多克隆抗體
  • 貨號:
    CSB-PA004822LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Mouse liver tissue, Rat liver tissue
      All lanes: CCNH antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 38 kDa
      Observed band size: 38 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA004822LA01HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CCNH Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    6330408H09Rik antibody; AI661354 antibody; AV102684 antibody; AW538719 antibody; CAK antibody; CAK complex subunit antibody; ccnh antibody; CCNH_HUMAN antibody; CDK activating kinase antibody; CDK activating kinase complex subunit antibody; Cyclin dependent kinase activating kinase antibody; cyclin dependent kinase activating kinase complex subunit antibody; Cyclin H antibody; Cyclin-H antibody; CyclinH antibody; MO15 associated protein antibody; MO15-associated protein antibody; p34 antibody; p36 antibody; p37 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human Cyclin-H protein (261-319AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,CCNH Antibody (CSB-PA004822LA01HU),的標記方式是Non-conjugated。對于CCNH Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA004822LB01HU CCNH Antibody, HRP conjugated ELISA
    FITC CSB-PA004822LC01HU CCNH Antibody, FITC conjugated
    Biotin CSB-PA004822LD01HU CCNH Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
  • 基因功能參考文獻:
    1. Expressions of components of the CAK complex, CDK7, MAT1, and Cyclin H are elevated in breast cancer. PMID: 27301701
    2. Our results indicated that CCNH/CDK7-CtBP2 axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of esophageal squamous cell carcinoma . PMID: 25820824
    3. SNPs in CCNH and ABCG2 can modulate the development of severe oxaliplatin-induced peripheral neuropathy. PMID: 24351404
    4. Hemodynamic forces modulate EC proliferative phenotype through the miR-23b/CAK/cyclin H pathway. PMID: 24855060
    5. When considering all thyroid cancer (DTC) cases, only rs2230641 (CCNH) was associated with DTC risk. PMID: 23982724
    6. CCNH and CDK7 may play an important role in the tumorigenesis and development of esophageal squamous cell carcinoma. PMID: 23456497
    7. High Cyclin H is associated with gastrointestinal stromal tumours. PMID: 20598140
    8. The expression of cyclin H and CDK7 protein in proliferating hemangiomas was significantly higher than that in involuting hemangiomas and normal skin tissues. PMID: 18950027
    9. The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H. PMID: 12140753
    10. Confocal microscopy revealed the co-localization of PKC-iota with CAK/cdk7 in both the cytoplasm and nucleus of U-373 MG glioma cells, supporting its role in cell signaling PMID: 15695176
    11. In response to ATRA, PML/RARalpha is dissociated from CAK, leading to MAT1 degradation, G1 arrest, and decreased CAK phosphorylation of PML/RARalpha PMID: 16935935
    12. Retinoic-acid-induced RAR-CAK signaling events appear to proceed intrinsically during granulocytic development of normal primitive hematopoietic cells. ALDH-governed RA availability may mediate this process by initiating RAR-CAK signaling. PMID: 17628022
    13. These results suggested that genetic variants in CAK genes, Cdk7, cyclin H, MAT1, might modulate the risk of lung cancer in a gene-gene interaction mode, which consist to the biochemical interaction of corresponding proteins. PMID: 17707548
    14. Our study demonstrates the independent prognostic value of cyclin H expression in diffuse large B-cell lymphoma and proposes its use as a prognostic marker. PMID: 18400256
    15. TFIIH changes subunit composition in response to DNA damage. The CAK is released from the core during nucleotide excision repair (NER). PMID: 18614043

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Cyclin family, Cyclin C subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1594

    OMIM: 601953

    KEGG: hsa:902

    STRING: 9606.ENSP00000256897

    UniGene: Hs.292524



主站蜘蛛池模板: 成人精品视频一区二区三区| 熟女性饥渴一区二区三区| 亚洲欧美日韩综合久久久久久| 国产精品久久久久高潮| a一区二区三区乱码在线 | 欧洲| 亚洲熟女综合一区二区三区| 国内精品国语自产拍在线观看| 国产亚洲精品自在久久vr| 国产成人精品一区二区三区| 欧美性猛交xxxx免费视频软件| 美女mm131爽爽爽作爱| 日韩高清在线观看永久| 亚洲 a v无 码免 费 成 人 a v| 中文字幕日本人妻久久久免费| 久久精品国产99久久6动漫| 中国丰满熟妇av| 秋霞影院午夜伦a片欧美| 国产精品久久精品国产| 精品午夜福利在线视在亚洲| 大胆日本熟妇xxxx| 欧美乱大交xxxxx潮喷l头像| 日韩欧美中文字幕在线三区| 亚洲乱亚洲乱妇无码麻豆| 久久久久成人片免费观看蜜芽| 亚洲国产精品无码久久久久高潮 | 人人爽人人添人人超| 国产农村妇女毛片精品久久| 亚洲精品久久久www| 尤物国精品午夜福利视频| 午夜无码成人免费视频| 中文字幕无码乱人伦| 99久久久无码国产精品试看| 九九线精品视频在线观看| 久青草久青草视频在线观看| 久久久久高潮综合影院| 一边摸一边做爽的视频17国产| 久久久精品妇女99| 日本在线视频www色| 玩弄放荡人妻一区二区三区| 亚洲成色综合网站在线| 曰批全过程免费视频在线观看无码|