在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CCNH Antibody, FITC conjugated

CCNH Antibody, FITC conjugated

  • 中文名稱：
    CCNH兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA004822LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CCNH Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    6330408H09Rik antibody; AI661354 antibody; AV102684 antibody; AW538719 antibody; CAK antibody; CAK complex subunit antibody; ccnh antibody; CCNH_HUMAN antibody; CDK activating kinase antibody; CDK activating kinase complex subunit antibody; Cyclin dependent kinase activating kinase antibody; cyclin dependent kinase activating kinase complex subunit antibody; Cyclin H antibody; Cyclin-H antibody; CyclinH antibody; MO15 associated protein antibody; MO15-associated protein antibody; p34 antibody; p36 antibody; p37 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Cyclin-H protein (261-319AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
  • 基因功能參考文獻：
    1. Expressions of components of the CAK complex, CDK7, MAT1, and Cyclin H are elevated in breast cancer. PMID: 27301701
    2. Our results indicated that CCNH/CDK7-CtBP2 axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of esophageal squamous cell carcinoma . PMID: 25820824
    3. SNPs in CCNH and ABCG2 can modulate the development of severe oxaliplatin-induced peripheral neuropathy. PMID: 24351404
    4. Hemodynamic forces modulate EC proliferative phenotype through the miR-23b/CAK/cyclin H pathway. PMID: 24855060
    5. When considering all thyroid cancer (DTC) cases, only rs2230641 (CCNH) was associated with DTC risk. PMID: 23982724
    6. CCNH and CDK7 may play an important role in the tumorigenesis and development of esophageal squamous cell carcinoma. PMID: 23456497
    7. High Cyclin H is associated with gastrointestinal stromal tumours. PMID: 20598140
    8. The expression of cyclin H and CDK7 protein in proliferating hemangiomas was significantly higher than that in involuting hemangiomas and normal skin tissues. PMID: 18950027
    9. The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H. PMID: 12140753
    10. Confocal microscopy revealed the co-localization of PKC-iota with CAK/cdk7 in both the cytoplasm and nucleus of U-373 MG glioma cells, supporting its role in cell signaling PMID: 15695176
    11. In response to ATRA, PML/RARalpha is dissociated from CAK, leading to MAT1 degradation, G1 arrest, and decreased CAK phosphorylation of PML/RARalpha PMID: 16935935
    12. Retinoic-acid-induced RAR-CAK signaling events appear to proceed intrinsically during granulocytic development of normal primitive hematopoietic cells. ALDH-governed RA availability may mediate this process by initiating RAR-CAK signaling. PMID: 17628022
    13. These results suggested that genetic variants in CAK genes, Cdk7, cyclin H, MAT1, might modulate the risk of lung cancer in a gene-gene interaction mode, which consist to the biochemical interaction of corresponding proteins. PMID: 17707548
    14. Our study demonstrates the independent prognostic value of cyclin H expression in diffuse large B-cell lymphoma and proposes its use as a prognostic marker. PMID: 18400256
    15. TFIIH changes subunit composition in response to DNA damage. The CAK is released from the core during nucleotide excision repair (NER). PMID: 18614043

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Cyclin family, Cyclin C subfamily
  • 數據庫鏈接：

    HGNC: 1594

    OMIM: 601953

    KEGG: hsa:902

    STRING: 9606.ENSP00000256897

    UniGene: Hs.292524



主站蜘蛛池模板： 国产欧美成人一区二区a片| 国产萌白酱喷水视频在线播放 | 国产成人欧美日韩在线电影 | 国产无遮挡又黄又爽在线视频| 三个男人躁我一个爽视频免费| 天堂资源中文| 2018国产大陆天天弄| 最新色国产精品精品视频| 国产成人片无码免费视频软件| 久久99精品国产麻豆婷婷洗澡| 欧美老熟妇xb水多毛多| 午夜理论在线观看不卡大地影院| 国产精品国产对白熟妇| 国产精品久久久久久影视不卡| 人妻无码久久精品人妻| 日本一道综合久久aⅴ久久| 国产又粗又黄又爽的大片| 久久久久久久久888| 日韩成人极品在线内射3p蜜臀 | 亚洲精品乱码久久久久久日本| 欧洲免费无线码在线一区 | 欧美506070老妇乱子伦| 亚洲国产品综合人成综合网站| 欧美极品少妇无套实战| 高潮添下面视频免费看| 免费观看四虎精品国产地址| 国产第一页浮力影院草草| 欧美日韩亚洲国产欧美电影| 最新国产麻豆aⅴ精品无码| 国产黄大片在线观看| 欧美激情乱人伦| 被窝影院午夜无码国产| 国产女人乱人伦精品一区二区| 熟妇人妻av无码一区二区三区 | 欧美色偷偷亚洲天堂bt| 亚洲中文字幕无码久久| 国产成人无码区免费内射一片色欲| 婷婷五月俺也去人妻| 人妻无码av中文系列久| 国产熟女一区二区三区四区五区| 午夜影视啪啪免费体验区入口|