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  4. CCL14 Antibody, HRP conjugated

CCL14 Antibody, HRP conjugated

  • 中文名稱：
    CCL14兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA08947B0Rb
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CCL14 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CC-1 antibody; CC-3 antibody; CCL14 antibody; CCL14_HUMAN antibody; chemokine (C-C motif) ligand 14 antibody; Chemokine CC-1/CC-3 antibody; chemokine CC1 antibody; chemokine CC3 antibody; chemokine HCC1 antibody; chemokine HCC3 antibody; CKb1 antibody; HCC 1 antibody; HCC 3 antibody; HCC-1(1-74) antibody; HCC-1(9-74) antibody; HCC-1/HCC-3 antibody; HCC-3 antibody; HCC1 antibody; HEMOFILTRATE CC CHEMOKINE 1 antibody; MCIF antibody; NCC-2 antibody; NCC2 antibody; new CC chemokine 2 antibody; SCYA14 antibody; SCYL2 antibody; small inducible cytokine subfamily A (Cys-Cys); member 14 antibody; Small-inducible cytokine A14 antibody; SY14 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human C-C motif chemokine 14 protein (20-93AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
  • 基因功能參考文獻：
    1. TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival PMID: 28718365
    2. CCL14 is a critical mediator of the JARID1B/LSD1/NuRD complex in regulation of angiogenesis and metastasis in breast cancer. PMID: 21937684
    3. enhanced expression in intestinal epithelium in inflammatory bowel disease and display of antibacterial activity PMID: 19812544
    4. Functional data from activity assays by intracellular calcium flux and inhibition of CCR5-mediated HIV-1 entry show that only CCL14 [9-74] is fully active at these near-physiological concentrations where CCL14 [9-74] is monomeric and CCL14 is dimeric PMID: 17691823
    5. CCL14 is involved in mechanisms by which trophoblast cells migrate during early pregnancy. PMID: 18367676
    6. SLE, this study reveals strong associations with a marker and a haplotype encompassing the CCL14 gene, which suggests that a lupus relevant variant may lie within or in the proximity of this haplotype. PMID: 18602166
    7. the activity of CCL14a might be regulated by stringent proteolytic activation and inactivation steps PMID: 19553544
    8. D6 cooperates with CD26 in the negative regulation of CCL14 by the selective degradation of its biologically active isoform. PMID: 19632987

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
  • 數據庫鏈接：

    HGNC: 10612

    OMIM: 601392

    KEGG: hsa:6358

    UniGene: Hs.272493



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