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  4. Human C-C motif chemokine 14(CCL14) ELISA kit

Human C-C motif chemokine 14(CCL14) ELISA kit

  • 中文名稱：
    人CC趨化因子14(CCL14)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL004777HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人CC趨化因子14(CCL14)酶聯(lián)免疫試劑盒（CSB-EL004777HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL14含量。CCL14是一個靶點。它在免疫調(diào)節(jié)等方面有著重要背景，屬于趨化因子家族成員。研究機制上，其可與相應受體結合，介導細胞遷移與活化，在炎癥反應、腫瘤微環(huán)境等過程中發(fā)揮作用，對其深入研究有望為相關疾病治療提供新策略。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，靈敏度為0.039 ng/mL。適用于體外實驗中對CCL14蛋白的定量檢測，可用于探究其在炎癥性疾病、免疫調(diào)節(jié)異常或腫瘤微環(huán)境中的表達特征，為細胞信號通路研究、疾病模型構建或藥物作用機制分析等科研項目提供可靠的數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    CC-1 ELISA Kit; CC-3 ELISA Kit; CCL14 ELISA Kit; CCL14_HUMAN ELISA Kit; chemokine (C-C motif) ligand 14 ELISA Kit; Chemokine CC-1/CC-3 ELISA Kit; chemokine CC1 ELISA Kit; chemokine CC3 ELISA Kit; chemokine HCC1 ELISA Kit; chemokine HCC3 ELISA Kit; CKb1 ELISA Kit; HCC 1 ELISA Kit; HCC 3 ELISA Kit; HCC-1(1-74) ELISA Kit; HCC-1(9-74) ELISA Kit; HCC-1/HCC-3 ELISA Kit; HCC-3 ELISA Kit; HCC1 ELISA Kit; HEMOFILTRATE CC CHEMOKINE 1 ELISA Kit; MCIF ELISA Kit; NCC-2 ELISA Kit; NCC2 ELISA Kit; new CC chemokine 2 ELISA Kit; SCYA14 ELISA Kit; SCYL2 ELISA Kit; small inducible cytokine subfamily A (Cys-Cys); member 14 ELISA Kit; Small-inducible cytokine A14 ELISA Kit; SY14 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
  • 基因功能參考文獻：
    1. TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival PMID: 28718365
    2. CCL14 is a critical mediator of the JARID1B/LSD1/NuRD complex in regulation of angiogenesis and metastasis in breast cancer. PMID: 21937684
    3. enhanced expression in intestinal epithelium in inflammatory bowel disease and display of antibacterial activity PMID: 19812544
    4. Functional data from activity assays by intracellular calcium flux and inhibition of CCR5-mediated HIV-1 entry show that only CCL14 [9-74] is fully active at these near-physiological concentrations where CCL14 [9-74] is monomeric and CCL14 is dimeric PMID: 17691823
    5. CCL14 is involved in mechanisms by which trophoblast cells migrate during early pregnancy. PMID: 18367676
    6. SLE, this study reveals strong associations with a marker and a haplotype encompassing the CCL14 gene, which suggests that a lupus relevant variant may lie within or in the proximity of this haplotype. PMID: 18602166
    7. the activity of CCL14a might be regulated by stringent proteolytic activation and inactivation steps PMID: 19553544
    8. D6 cooperates with CD26 in the negative regulation of CCL14 by the selective degradation of its biologically active isoform. PMID: 19632987

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10612

    OMIM: 601392

    KEGG: hsa:6358

    UniGene: Hs.272493



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