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  4. CADM4 Antibody

CADM4 Antibody

  • 中文名稱(chēng)：
    CADM4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA246478
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA246478(CADM4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA246478(CADM4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: RAW264.7 cells, mouse brain tissue, Primary antibody: CSB-PA246478(CADM4 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CADM4
  • 別名：
    CADM 4 antibody; cadm4 antibody; CADM4_HUMAN antibody; Cell adhesion molecule 4 antibody; IGSF4C antibody; Immunoglobulin superfamily member 4C antibody; Necl 4 antibody; NECL-4 antibody; NECL4 antibody; Nectin like 4 antibody; Nectin like protein 4 antibody; Nectin-like protein 4 antibody; synCAM4 antibody; TSLC1 like 2 antibody; TSLC1 like protein 2 antibody; TSLC1-like protein 2 antibody; TSLL2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human CADM4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.
  • 基因功能參考文獻(xiàn)：
    1. There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 in gastric or colon adenocarcinomas PMID: 28561015
    2. Low CADM4 expression is associated with bone marrow metastasis in neuroblastoma. PMID: 28921546
    3. The results suggest that Necl-4 enhances VEGF-induced activation of PLCgamma-c-Raf-MEK-ERK pathway without affecting the phosphorylation and internalization of VEGFR2. PMID: 28601637
    4. Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13 PMID: 25893857
    5. results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly PMID: 23611113
    6. Loss or decrease of CADM4 expression seems to play an important role in breast cancer invasiveness, and it is associated with poorer biological parameters. PMID: 23559354
    7. Cadm4 regulates the growth of the myelin unit and the organization of the underlying axonal membrane. PMID: 23825401
    8. CADM4, as well as 4.1B is expressed specifically in human proximal tubules. PMID: 21544807
    9. Nec- 4 suppress the growth and tumorigenic ability of colon cancer cells. PMID: 19565570
    10. TSLL2 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate, and is a tumor-suppressor candidate in prostate cancer. PMID: 16261159

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Nectin family
  • 組織特異性：
    Expressed in brain, prostate, brain, kidney and some other organs.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30825

    OMIM: 609744

    KEGG: hsa:199731

    STRING: 9606.ENSP00000222374

    UniGene: Hs.370984



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