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CADM4 Antibody

  • 中文名稱:
    CADM4兔多克隆抗體
  • 貨號:
    CSB-PA207693
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from RAW264.7 cells, using CADM4 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using CADM4 antibody.
    • Immunofluorescence analysis of A549 cells, using CADM4 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CADM4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CADM4
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human CADM4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.
  • 基因功能參考文獻:
    1. There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 in gastric or colon adenocarcinomas PMID: 28561015
    2. Low CADM4 expression is associated with bone marrow metastasis in neuroblastoma. PMID: 28921546
    3. The results suggest that Necl-4 enhances VEGF-induced activation of PLCgamma-c-Raf-MEK-ERK pathway without affecting the phosphorylation and internalization of VEGFR2. PMID: 28601637
    4. Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13 PMID: 25893857
    5. results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly PMID: 23611113
    6. Loss or decrease of CADM4 expression seems to play an important role in breast cancer invasiveness, and it is associated with poorer biological parameters. PMID: 23559354
    7. Cadm4 regulates the growth of the myelin unit and the organization of the underlying axonal membrane. PMID: 23825401
    8. CADM4, as well as 4.1B is expressed specifically in human proximal tubules. PMID: 21544807
    9. Nec- 4 suppress the growth and tumorigenic ability of colon cancer cells. PMID: 19565570
    10. TSLL2 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate, and is a tumor-suppressor candidate in prostate cancer. PMID: 16261159

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  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Nectin family
  • 組織特異性:
    Expressed in brain, prostate, brain, kidney and some other organs.
  • 數據庫鏈接:

    HGNC: 30825

    OMIM: 609744

    KEGG: hsa:199731

    STRING: 9606.ENSP00000222374

    UniGene: Hs.370984



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