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  4. CADM3 Antibody

CADM3 Antibody

  • 中文名稱：
    CADM3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA004427LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA004427LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA004427LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Rat stomach tissue, Mouse kidney tissue
      All lanes: CADM3 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 44, 48, 39 kDa
      Observed band size: 44 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CADM3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CADM3
  • 別名：
    BIgR antibody; Brain immunoglobulin receptor antibody; CADM 3 antibody; cadm3 antibody; CADM3_HUMAN antibody; Cell adhesion molecule 3 antibody; Dendritic cell nectin like protein 1 short isoform antibody; FLJ10698 antibody; IgSF4B antibody; Immunoglobulin superfamily member 4B antibody; Necl 1 antibody; Necl-1 antibody; NECL1 antibody; Nectin like 1 antibody; Nectin like protein 1 antibody; Nectin-like protein 1 antibody; Synaptic cell adhesion molecule 3 antibody; synCAM3 antibody; TSLC1 like 1 antibody; TSLC1 like protein 1 antibody; TSLC1-like protein 1 antibody; TSLL1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Cell adhesion molecule 3 protein (140-328AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，CADM3 Antibody (CSB-PA004427LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于CADM3 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA004427LB01HU CADM3 Antibody, HRP conjugated ELISA
    FITC CSB-PA004427LC01HU CADM3 Antibody, FITC conjugated
    Biotin CSB-PA004427LD01HU CADM3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.
  • 基因功能參考文獻(xiàn)：
    1. CADM3 expression was increased in retinoblastoma tissues and cells. miR-140-5p inhibited CADM3 expression possibly by targeting the 3'-UTR. PMID: 29808799
    2. Nectin-based cell-cell adhesion was formed at the apical side of the junctional adhesion molecule (JAM)-based cell-cell adhesion; cadherin and claudin were recruited to the nectin-3 and JAM-based cell-cell adhesion sites to form AJ- and TJ-like domains. PMID: 24112238
    3. NECL1 can inhibit the migration and invasion of glioma cells and induce differentiation. PMID: 20078932
    4. Findings clearly reveal the structural basis for the cis-dimerization of nectins through the first Ig-like domains. PMID: 21325282
    5. A link might exist between NECL1 and the extracellular matrix protein OPN in inhibiting the migration and invasion of U251 glioma ce PMID: 20598232
    6. NECL1 may inhibit the proliferation of T98G cells by inducing its apoptosis. PMID: 18686605
    7. Nec- 1 suppress the growth and tumorigenic ability of colon cancer cells. PMID: 19565570
    8. Necl-1 is a neural-tissue-specific Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which potentially has membrane-associated guanylate kinase subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites PMID: 15741237
    9. crystallographic analysis of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule PMID: 16467305
    10. human NECL1 is an N-linked glycoprotein with a single glycosylation site at position N290KS PMID: 18420026
    11. Expression of entry receptors nectin-1 and HVEM prevent entry of HSV-1 into human conjunctival epithelium. PMID: 18502984
    12. suggests that NECL1 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation PMID: 19062177

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction.
  • 蛋白家族：
    Nectin family
  • 組織特異性：
    Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17601

    OMIM: 609743

    KEGG: hsa:57863

    UniGene: Hs.365689



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