在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CACNA2D1 Antibody

  • 中文名稱:
    CACNA2D1兔多克隆抗體
  • 貨號:
    CSB-PA080288
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CA2D1_HUMAN antibody; CACN A2 antibody; CACNA2 antibody; Cacna2d1 antibody; CACNL2A antibody; Calcium channel L type alpha 2 polypeptide antibody; Calcium channel voltage dependent alpha 2/delta subunit 1 antibody; CCHL2A antibody; Dihydropyridine receptor alpha 2 subunit antibody; Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit antibody; Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta antibody; L type calcium channel subunit alpha 2 antibody; MHS 3 antibody; MHS3 antibody; Voltage dependent calcium channel subunit alpha 2/delta 1 antibody; Voltage gated calcium channel subunit alpha 2/delta 1 antibody; Voltage-dependent calcium channel subunit delta-1 antibody; Voltage-gated calcium channel subunit alpha-2/delta-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Rat
  • 免疫原:
    Synthetic Peptide
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
  • 基因功能參考文獻:
    1. Using human genome-wide association study (GWAS) data, evidence for association of a CACNA2D1 single-nucleotide polymorphism and primary open angle glaucoma is found. PMID: 29176626
    2. we report an additional patient with the 7q21.11 deletion syndrome and provide evidence that haploinsufficiency for a single gene may not be the disease mechanism. In vitro studies of the interaction between PCLO and CACNA2D1 will be required to examine the hypothesis that combined haploinsufficiency for these two synaptic proteins results in neuronal dysfunction PMID: 28240412
    3. All three patients present with epilepsy and intellectual disability pinpointing the CACNA2D1 gene as an interesting candidate gene for these clinical features. PMID: 25074461
    4. Compound mutation of CACNA2D1 and RANGRF genes were found. To the best of our knowledge, this is the first comprehensive description of the concurrence of these two mutations and histiocytoid cardiomyopathy. PMID: 24438356
    5. High prevalence of CACNA2D1, SCN5A, and CACNB2 genetic variants in the Danish population previously associated with Brugada syndrome has been found in new exome data. PMID: 23414114
    6. Functional expression of CACNA2D1 is inhibited by prion protein expression with competition at glycosylphosphatidylinositol. PMID: 24329154
    7. this study reports the identification and characterization of the human alpha2delta-1 subunit gene promoter region and its regulation by specific transcription factor 1. PMID: 23242029
    8. (Review) In neurons, alpha2delta1 subunits are present mainly in presynaptic terminals; peripheral sensory nerve injury results in up-regulation of alpha2delta1 in dorsal root ganglion neurons, and there is consequent increase in trafficking of alpha2delta1 to their terminals. PMID: 20579869
    9. In neocortical slices from transgenic mice having a point mutation (i.e., R217A) of the alpha2delta-1 subunit of voltage-sensitive calcium channels, pregabalin does not affect potassium-evoked glutamate release, yet inhibits this release in wild-type mice. PMID: 21464332
    10. Results show that mutation of CACNA2D1 gene causes a new varant of SCTS. PMID: 21383000
    11. CACNA2D1 is a novel Brugada Syndrome susceptibility gene. PMID: 20817017
    12. CACNA2D1 has structural domains which contribute to the regulation of N-type calcium channel inactivation PMID: 14602720
    13. Timothy syndrome is a disease of excessive cellular Ca(2+) entry and life-threatening arrhythmias caused by a mutation in the primary cardiac L-type Ca(2+) channel (Ca(V)1.2). PMID: 19001023

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Calcium channel subunit alpha-2/delta family
  • 組織特異性:
    Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.
  • 數據庫鏈接:

    HGNC: 1399

    OMIM: 114204

    KEGG: hsa:781

    STRING: 9606.ENSP00000349320

    UniGene: Hs.282151



主站蜘蛛池模板: 久久国产中文娱乐网| 嫖妓大龄熟妇正在播放| 国产男女嘿咻视频在线观看| 国产美女精品视频线免费播放| 亚洲国产精品美女久久久久| 色综合久久久久久久久五月| 青青草大香焦在线综合视频| 人人妻人人澡人人爽欧美一区| 亚州中文字幕无码中文字幕 | 老司机午夜福利视频| 强迫大乳人妻中文字幕| 美女又大又黄www免费网站| 国产精品久久久久久52avav | 亚洲欧洲免费三级网站| 亚洲欧洲日产国码无码| 国产无套中出学生姝| 国产精品一区二区久久精品| 亚洲免费网站观看视频| 狠狠做五月深爱婷婷伊人| 国产精品毛片无码| 国产高清视频一区三区| 天天狠天天透天干天天| aⅴ亚洲 日韩 色 图网站 播放| www一区二区www免费| 国产乱人伦偷精品视频免下载| 午夜男女无遮挡拍拍视频| 老湿机香蕉久久久久久| 亚洲精品久久久久玩吗| 久久亚洲私人国产精品| 性色av无码中文av有码vr| 国产精品国产三级在线...| 人人入人人爱| 无码少妇a片一区二区三区| 蜜臀色欲av在线播放国产日韩| 国产一卡二卡三卡四卡视频版| 成人爽a毛片免费啪啪| 国产一区二区精品久久| 成人麻豆亚洲综合无码精品| 香蕉久久精品日日躁夜夜躁夏| 麻豆 美女 丝袜 人妻 中文| 久青草国产97香蕉在线影院|