在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CACNA2D1 Antibody

  • 中文名稱:
    CACNA2D1兔多克隆抗體
  • 貨號(hào):
    CSB-PA004407LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunofluorescence staining of Hela cells with CSB-PA004407LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA004407LA01HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:

    The CACNA2D1 polyclonal antibody was produced by introducing the recombinant human voltage-dependent calcium channel subunit alpha-2/delta-1 protein (577-717aa) into rabbits and inducing an immune response that produces antibodies against the CACNA2D1 protein. The rabbit's blood was then collected, and the serum containing the CACNA2D1 polyclonal antibodies was isolated and purified via protein G chromatography. It has high purity, up to 95%, which ensures accurate and reliable results.

    The CACNA2D1 polyclonal antibody is capable of reacting with human samples. It has been tested in ELISA, IHC, and IF applications, allowing for the detection of the presence and quantity, visualization of distribution and localization, and identification of the CACNA2D1 protein.

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CACNA2D1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CA2D1_HUMAN antibody; CACN A2 antibody; CACNA2 antibody; Cacna2d1 antibody; CACNL2A antibody; Calcium channel L type alpha 2 polypeptide antibody; Calcium channel voltage dependent alpha 2/delta subunit 1 antibody; CCHL2A antibody; Dihydropyridine receptor alpha 2 subunit antibody; Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit antibody; Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta antibody; L type calcium channel subunit alpha 2 antibody; MHS 3 antibody; MHS3 antibody; Voltage dependent calcium channel subunit alpha 2/delta 1 antibody; Voltage gated calcium channel subunit alpha 2/delta 1 antibody; Voltage-dependent calcium channel subunit delta-1 antibody; Voltage-gated calcium channel subunit alpha-2/delta-1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-1 protein (577-717AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,CACNA2D1 Antibody (CSB-PA004407LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于CACNA2D1 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA004407LB01HU CACNA2D1 Antibody, HRP conjugated ELISA
    FITC CSB-PA004407LC01HU CACNA2D1 Antibody, FITC conjugated
    Biotin CSB-PA004407LD01HU CACNA2D1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:500
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
  • 基因功能參考文獻(xiàn):
    1. Using human genome-wide association study (GWAS) data, evidence for association of a CACNA2D1 single-nucleotide polymorphism and primary open angle glaucoma is found. PMID: 29176626
    2. we report an additional patient with the 7q21.11 deletion syndrome and provide evidence that haploinsufficiency for a single gene may not be the disease mechanism. In vitro studies of the interaction between PCLO and CACNA2D1 will be required to examine the hypothesis that combined haploinsufficiency for these two synaptic proteins results in neuronal dysfunction PMID: 28240412
    3. All three patients present with epilepsy and intellectual disability pinpointing the CACNA2D1 gene as an interesting candidate gene for these clinical features. PMID: 25074461
    4. Compound mutation of CACNA2D1 and RANGRF genes were found. To the best of our knowledge, this is the first comprehensive description of the concurrence of these two mutations and histiocytoid cardiomyopathy. PMID: 24438356
    5. High prevalence of CACNA2D1, SCN5A, and CACNB2 genetic variants in the Danish population previously associated with Brugada syndrome has been found in new exome data. PMID: 23414114
    6. Functional expression of CACNA2D1 is inhibited by prion protein expression with competition at glycosylphosphatidylinositol. PMID: 24329154
    7. this study reports the identification and characterization of the human alpha2delta-1 subunit gene promoter region and its regulation by specific transcription factor 1. PMID: 23242029
    8. (Review) In neurons, alpha2delta1 subunits are present mainly in presynaptic terminals; peripheral sensory nerve injury results in up-regulation of alpha2delta1 in dorsal root ganglion neurons, and there is consequent increase in trafficking of alpha2delta1 to their terminals. PMID: 20579869
    9. In neocortical slices from transgenic mice having a point mutation (i.e., R217A) of the alpha2delta-1 subunit of voltage-sensitive calcium channels, pregabalin does not affect potassium-evoked glutamate release, yet inhibits this release in wild-type mice. PMID: 21464332
    10. Results show that mutation of CACNA2D1 gene causes a new varant of SCTS. PMID: 21383000
    11. CACNA2D1 is a novel Brugada Syndrome susceptibility gene. PMID: 20817017
    12. CACNA2D1 has structural domains which contribute to the regulation of N-type calcium channel inactivation PMID: 14602720
    13. Timothy syndrome is a disease of excessive cellular Ca(2+) entry and life-threatening arrhythmias caused by a mutation in the primary cardiac L-type Ca(2+) channel (Ca(V)1.2). PMID: 19001023

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Calcium channel subunit alpha-2/delta family
  • 組織特異性:
    Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1399

    OMIM: 114204

    KEGG: hsa:781

    STRING: 9606.ENSP00000349320

    UniGene: Hs.282151



主站蜘蛛池模板: 美女扒开大腿让男人桶| 免费啪视频在线观看视频日本| 成人无码精品一区二区三区| 亚洲精品成人av观看| 国产在线精品一区二区三区| 色欲色香天天天综合vvv| 国产精品ⅴ无码大片在线看 | 少妇一夜三次一区二区| 亚洲精品国产品国语原创| 香蕉久久人人97超碰caoproen| 黑人巨茎大战白人美女| 国产成人精品综合久久久久| 国产欧美va天堂在线电影| 国产av综合第一页| 377人体粉嫩噜噜噜| 久久国产劲爆∧v内射| 精品麻豆一区二区三区乱码| 中老年熟妇激情啪啪大屁股| 亚洲a无码综合a国产av中文| 青草青草久热精品视频在线观看| 国产精品白丝av在线观看播放| 欧洲精品无码一区二区三区在线播放 | 风韵多水的老熟妇| 精品国产乱码久久久久久1区2区 | 一区二三区在线 | 中国| 人人妻人人澡人人爽不卡视频| 国产高清视频一区三区| 樱花草在线社区www日本影院| 国内久久婷婷六月综合欲色啪| 成年女人毛片免费视频| av无码小缝喷白浆在线观看| 性xxx欧美老妇5060.70| 在线观看特色大片免费视频| 国产乱人伦精品一区二区| 成人国产三级在线观看| 亚洲国产精品va在线观看麻豆| 欧洲成人午夜精品无码区久久| 国产一区二区三区影院| 日韩国产网曝欧美第一页| 少妇愉情理伦片bd| 色先锋av影音先锋在线|