在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CA12 Antibody, Biotin conjugated

  • 中文名稱:
    CA12兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA004367YD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CA12 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CA 12 antibody; CA XII antibody; CA-XII antibody; CA12 antibody; CAH12_HUMAN antibody; Carbonate dehydratase XII antibody; Carbonic anhydrase 12 antibody; Carbonic anhydrase XII antibody; Carbonic dehydratase antibody; CAXII antibody; FLJ20151 antibody; HsT18816 antibody; T18816 antibody; Tumor antigen HOM RCC 3.1.3 antibody; Tumor antigen HOM-RCC-3.1.3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Carbonic anhydrase 12 protein (25-301AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Reversible hydration of carbon dioxide.
  • 基因功能參考文獻:
    1. Our findings indicate that loss of CA XII function should be considered in individuals without CFTR mutations who exhibit CF-like features in the sweat gland and lung. PMID: 26911677
    2. The expression of HIF-1alpha, but not HIF-2alpha, decreased in degenerated disc samples and was positively correlated with carbonic anhydrase 12 expression. PMID: 26901836
    3. mutation CA12(E143K) causes mouth dryness disease due to aberrant CA12 glycosylation. PMID: 26486891
    4. Suggest CAXII as a new secondary marker of the multidrug resistance phenotype that influences Pgp activity directly. PMID: 25686827
    5. an upregulation of CAXII in human T-cell acute lymphoblastic leukemia samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL. PMID: 23348702
    6. Serum CAXII levels were significantly higher in lung cancer patients than in healthy controls, providing evidence that CAXII may be a novel sero-diagnostic marker for lung cancer. PMID: 22439015
    7. The expression of CA XII in oral squamous cell carcinoma (OSCC) samples can predict the progression of OSCC and survival of OSCC patients. PMID: 22172588
    8. The development of acidosis with topiramate and zonisamide is not determined by drug dose or by treatment duration, but may be influenced by polymorphisms in the gene for CA type XII. PMID: 21278619
    9. Data show that genes overexpressed in breast carcinoma including TFF1, TFF3, FOXA1 and CA12.Data show that genes overexpressed in breast carcinoma including TFF1, TFF3, FOXA1 and CA12. PMID: 20132413
    10. Study identified the association of a Glu143Lys mutation in carbonic anhydrase 12 (CA12) with the disease. PMID: 21184099
    11. we demonstrate that the hyperchlohidrosis phenotype is due to a homozygous mutation in CA12, encoding carbonic anhydrase XII. PMID: 21035102
    12. CA12 may be used as a novel prognostic marker in combination with histologic grade of invasive cervical cancer. PMID: 21040567
    13. Carbonic anhydrase XII may affect the capability of invasion and migration of MDA-MB-231 cells, which may be mediated through the p38 MAPK pathway. PMID: 20434230
    14. Suggest that CA XII should be considered a potential prognostic and therapeutic target in medulloblastomas and supratentorial primitive neuroectodermal tumours. PMID: 20398423
    15. Differential modulation of the active site environment of human carbonic anhydrase XII by cationic quantum dots and polylysine. PMID: 20215053
    16. The non-pigmented ciliary epithelial cells from glaucoma eyes expressed higher levels of CAXII, which may be a targeted gene in glaucoma. PMID: 12676895
    17. CA XII showed no or weak immunoreaction in the normal gastric mucosa and was slightly increased in gastric tumors. PMID: 12854129
    18. The interplay between the functional von Hippel-Lindau tumor suppressor and CA IX/CA XII in colorectal tumors seems rather PMID: 15849821
    19. CA12 mRNA expression was detected in 88.1% of cervical cancers. PMID: 16416108
    20. CA XII is commonly expressed in diffuse astrocytomas and that it might be used as a biomarker of poor prognosis. PMID: 18322268
    21. Carbonic anhydrase (CA) IX (and possibly also CA XII) participates in pH regulation, which is important for survival of hypoxic cancer cells. Both enzymes are therefore promising targetable therapeutic molecules. [Review] PMID: 18336315
    22. Crucial role of ER in the regulation of the CA12 gene. PMID: 18451179
    23. In embryonic and early fetal tissues; there is no evidence of co-localization of CAIX and CAXII; CAIX and CAXII expression is closely related to cell origin and secretory activity involving proton transport, respectively. PMID: 19291313

    顯示更多

    收起更多

  • 相關疾病:
    Hyperchlorhidrosis, isolated (HCHLH)
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein. Cell membrane.
  • 蛋白家族:
    Alpha-carbonic anhydrase family
  • 組織特異性:
    Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. Expressed in sweat gl
  • 數據庫鏈接:

    HGNC: 1371

    OMIM: 143860

    KEGG: hsa:771

    STRING: 9606.ENSP00000178638

    UniGene: Hs.210995



主站蜘蛛池模板: 无码人妻专区免费视频| 亚洲高清国产拍精品网络战| 亚洲人成网站18禁止大| 久久99精品久久久久蜜芽| 国产精品一久久香蕉国产线看观看| 亚洲人成电影在线播放| 久久亚洲国产精品亚洲老地址| 久久精品国产久精国产爱| 无卡无码无免费毛片| 中字幕人妻一区二区三区| 97久久国产露脸精品国产| 好男人在在线社区www在线影院| 欧美老妇人与禽交| 色婷婷狠狠久久综合五月| 五月婷婷激情第四季| 日本高清无卡码一区二区| 久久av一区二区三区| 精品久久久久久久久久久国产字幕| 2020精品国产午夜福利在线观看| 国色天香社区在线视频| 成人精品视频99在线观看免费| www国产亚洲精品久久网站| 欧美性video高清精品| 欧美黑人又粗又大的性格特点| 日韩va中文字幕无码电影 | 日日噜噜夜夜爽爽| 特黄特级毛片免费视频| 亚洲中文字幕人成乱码| 欧美无遮挡很黄裸交视频| 国内揄拍国内精品少妇| 美女视频黄a视频全免费| 亚洲自偷自偷在线成人网址| 激情综合色综合啪啪五月丁香搜索| 欧美又粗又大xxxxbbbb疯狂 | 人妻在线日韩免费视频| 亚洲午夜久久久影院伊人| 无人区码一码二码w358cc| 色欲来吧来吧天天综合网| 亚洲小说春色综合另类| 老湿机69福利区无码| 国产精品国产午夜免费看福利|