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  4. C1D Antibody

C1D Antibody

  • 中文名稱：
    C1D兔多克隆抗體
  • 貨號：
    CSB-PA03474A0Rb
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate
      All lanes: C1D antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 17 kDa
      Observed band size: 17 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA03474A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA03474A0Rb at dilution of 1:100
    • Immunofluorescence staining of Hela cells with CSB-PA03474A0Rb at 1:533, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) C1D Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    C1D
  • 別名：
    1110036E10Rik antibody; AI875855 antibody; C1D antibody; C1D DNA binding protein antibody; C1D_HUMAN antibody; hC1D antibody; LRP1 antibody; MGC12261 antibody; MGC14659 antibody; MGC188504 antibody; Nuclear DNA binding protein antibody; Nuclear nucleic acid binding protein C1D antibody; Nuclear nucleic acid-binding protein C1D antibody; rCG23324 antibody; RGD1560600 antibody; Small unique nuclear receptor corepressor antibody; SUNCOR antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Nuclear nucleic acid-binding protein C1D protein (1-135AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，C1D Antibody (CSB-PA03474A0Rb)，的標記方式是Non-conjugated。對于C1D Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA03474B0Rb C1D Antibody, HRP conjugated ELISA
    FITC CSB-PA03474C0Rb C1D Antibody, FITC conjugated
    Biotin CSB-PA03474D0Rb C1D Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:2000-1:10000
    IHC 1:50-1:500
    IF 1:500-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB.
  • 基因功能參考文獻：
    1. C1D is associated with the DNA repair complex and may promote repair of ultraviolet irradiation-induced DNA damage. PMID: 20530579
    2. Results are consistent with a role for the exosome-associated protein C1D in the recruitment of the exosome to pre-rRNA to mediate the 3' end processing of the 5.8S rRNA. PMID: 17412707
    3. Anti-C1D autoantibodies were observed in patients with polymyositis-scleroderma overlap syndrome. PMID: 17599775
    4. TRAX enhances the DNA binding capacity of Translin, that binds to recombination regions in some malignancies. C1D interacts with TRAX following g-irradiation and prevents formation of TRAX/Translin complex, thereby inhibits any unwanted recombination. PMID: 11801738
    5. The C1D protein interacts with the catalytic subunit of DNA-PK and is a very effective substrate for DNA-PK in vitro. Moreover, C1D directs the activation of DNA-PK in a manner that does not require DNA termini, suggesting a role for C1D in DNA repair. PMID: 9679063

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Nucleus, nucleolus.
  • 蛋白家族：
    C1D family
  • 組織特異性：
    Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung an
  • 數據庫鏈接：

    HGNC: 29911

    OMIM: 606997

    KEGG: hsa:10438

    STRING: 9606.ENSP00000348107

    UniGene: Hs.602900



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