在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Bag3 Antibody

  • 中文名稱:
    Bag3兔多克隆抗體
  • 貨號:
    CSB-PA864372HA01MO
  • 規格:
    ¥440
  • 圖片:
    • Immunoprecipitating Bag3 in K562 whole cell lysate
      Lane 1: Rabbit control IgG (1µg) instead of CSB-PA864372HA01MO in K562 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA864372HA01MO (6µg) + K562 whole cell lysate (500µg)
      Lane 3: K562 whole cell lysate (10µg)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Mus musculus (Mouse) Bag3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Bag3 antibody; Bis antibody; MNCb-2243BAG family molecular chaperone regulator 3 antibody; BAG-3 antibody; Bcl-2-associated athanogene 3 antibody; Bcl-2-binding protein Bis antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Mouse
  • 免疫原:
    Recombinant Mouse BAG family molecular chaperone regulator 3 protein (2-577AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,Bag3 Antibody (CSB-PA864372HA01MO),的標記方式是Non-conjugated。對于Bag3 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA864372HB01MO Bag3 Antibody, HRP conjugated ELISA
    FITC CSB-PA864372HC01MO Bag3 Antibody, FITC conjugated
    Biotin CSB-PA864372HD01MO Bag3 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IP
  • 推薦稀釋比:
    Application Recommended Dilution
    IP 1:200-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.
  • 基因功能參考文獻:
    1. expression of the co-chaperone BAG3 and other chaperone-assisted selective autophagy factors was analyzed in the cellular, zebrafish and ky/ky mouse models. PMID: 29914939
    2. It is a cochaperone that mediates autophagy. PMID: 29304346
    3. Thus, BAG3 is critical for the protein turnover of small HSPs via activation of autophagy in the heart. PMID: 29409895
    4. BAG3 plays a relevant role in regulating SNCA clearance via macroautophagy, and the heat shock protein 70-BAG3-sequestosome 1 complex may be involved in this process. PMID: 28941726
    5. BAG3 directly stabilizes hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells. PMID: 29114069
    6. BAG3 expression is required for neuronal differentiation and migration. PMID: 28144784
    7. interaction between BAG3 and HSP70 is essential for BAG3 to stabilize small heat shock proteins and maintain cardiomyocyte protein homeostasis PMID: 28737513
    8. The spatial regulation of mTORC1 exerted by BAG3 apparently provides the basis for a simultaneous induction of autophagy and protein synthesis to maintain the proteome under mechanical strain. PMID: 27756573
    9. Genetic variation in BAG3 plays an important role in the prevention of ischemic tissue necrosis. PMID: 28442482
    10. The aim of this study was to investigate the possible hemodynamic effects of BAG3 performing both in vitro and in vivo experiments. PMID: 27763645
    11. Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the beta1-adrenergic receptor and L-type Ca(2+) channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure. PMID: 26796036
    12. molecular association of MyHC and BIS is necessary for MyHC stabilization in skeletal muscle. PMID: 27034027
    13. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. PMID: 26522614
    14. Bis is upregulated in astrocytes after hypoxia-ischemia; hypoxia-ischemia induces progressive cell death in the hippocampi of bis-positive mice, while hippocampal neurons are less vulnerable to hypoxia-ischemia in mice that lack Bis. PMID: 22907804
    15. Deletion of the bis gene results in a marked increase in the production of corticosterone that is associated with thymic atrophy. PMID: 21540452
    16. BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress. PMID: 20884878
    17. Results indicate that Bis functions to mediate cellular regulation of the stem cell niche on the vascular compartment. PMID: 20024912
    18. BAG3 alters the interaction between HSP70 and IKKgamma, increasing availability of IKKgamma and protecting it from proteasome-dependent degradation; this, in turn, results in increased NF-kappaB activity and survival PMID: 20368414
    19. BAG3 is not required for muscle development, this co-chaperone appears to be critically important for maintenance of mature skeletal muscle. PMID: 16936253
    20. The absence of Bis has considerable influences on postnatal growth and survival, possibly due to a nutritional impairment. PMID: 18840758

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲一区在线日韩在线秋葵| 人妻少妇精品一区二区三区| 一区二区国产高清视频在线| 无遮挡裸体免费视频尤物| 精品 日韩 国产 欧美 视频| 成人亚洲欧美一区二区三区| 亚洲图片校园另激情类小说 | 久久精品国产久精国产一老狼| 一本一道中文字幕无码东京热| 日韩人妻少妇一区二区三区| 午夜一区一品日本| 精品无码人妻一区二区三区不卡| 日本黄页网站免费观看| 日本真人边吃奶边做爽动态图| 亚洲1卡二卡三新区2022| 国产熟女内射oooo| 女人爽到高潮免费视频大全| 99视频精品国产免费观看 | 亚洲精品乱码久久久久蜜桃| 国产精品久久久久无码av| 波多野结衣aⅴ在线| 亚洲色无码专区在线播放| 亚洲精品午夜无码电影网| 亚洲第一页综合图片自拍| 色两性网欧美| 亚洲一区在线日韩在线秋葵| 777米奇影院狠狠色| 人妻丰满熟av无码区hd| 久久久久女教师免费一区| 国产亚洲产品影视在线产品| 免费无码黄十八禁网站在线观看| 国产69精品久久久久人妻| 无码人妻一区二区三区免费n鬼沢| 秋霞av在线露丝片av无码| 永久中文字幕免费视频网站| 一边吃奶一边做动态图| 亚洲综合无码精品一区二区三区| 成人看的污污超级黄网站免费| 日本一区二区三区不卡免费| 欧精国精产品一区| 男人下部进女人下部视频|