在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Bag3 Antibody, HRP conjugated

Bag3 Antibody, HRP conjugated

  • 中文名稱：
    Bag3兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA864372HB01MO
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Mus musculus (Mouse) Bag3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Bag3 antibody; Bis antibody; MNCb-2243BAG family molecular chaperone regulator 3 antibody; BAG-3 antibody; Bcl-2-associated athanogene 3 antibody; Bcl-2-binding protein Bis antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Mouse
  • 免疫原：
    Recombinant Mouse BAG family molecular chaperone regulator 3 protein (2-577AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.
  • 基因功能參考文獻：
    1. expression of the co-chaperone BAG3 and other chaperone-assisted selective autophagy factors was analyzed in the cellular, zebrafish and ky/ky mouse models. PMID: 29914939
    2. It is a cochaperone that mediates autophagy. PMID: 29304346
    3. Thus, BAG3 is critical for the protein turnover of small HSPs via activation of autophagy in the heart. PMID: 29409895
    4. BAG3 plays a relevant role in regulating SNCA clearance via macroautophagy, and the heat shock protein 70-BAG3-sequestosome 1 complex may be involved in this process. PMID: 28941726
    5. BAG3 directly stabilizes hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells. PMID: 29114069
    6. BAG3 expression is required for neuronal differentiation and migration. PMID: 28144784
    7. interaction between BAG3 and HSP70 is essential for BAG3 to stabilize small heat shock proteins and maintain cardiomyocyte protein homeostasis PMID: 28737513
    8. The spatial regulation of mTORC1 exerted by BAG3 apparently provides the basis for a simultaneous induction of autophagy and protein synthesis to maintain the proteome under mechanical strain. PMID: 27756573
    9. Genetic variation in BAG3 plays an important role in the prevention of ischemic tissue necrosis. PMID: 28442482
    10. The aim of this study was to investigate the possible hemodynamic effects of BAG3 performing both in vitro and in vivo experiments. PMID: 27763645
    11. Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the beta1-adrenergic receptor and L-type Ca(2+) channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure. PMID: 26796036
    12. molecular association of MyHC and BIS is necessary for MyHC stabilization in skeletal muscle. PMID: 27034027
    13. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. PMID: 26522614
    14. Bis is upregulated in astrocytes after hypoxia-ischemia; hypoxia-ischemia induces progressive cell death in the hippocampi of bis-positive mice, while hippocampal neurons are less vulnerable to hypoxia-ischemia in mice that lack Bis. PMID: 22907804
    15. Deletion of the bis gene results in a marked increase in the production of corticosterone that is associated with thymic atrophy. PMID: 21540452
    16. BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress. PMID: 20884878
    17. Results indicate that Bis functions to mediate cellular regulation of the stem cell niche on the vascular compartment. PMID: 20024912
    18. BAG3 alters the interaction between HSP70 and IKKgamma, increasing availability of IKKgamma and protecting it from proteasome-dependent degradation; this, in turn, results in increased NF-kappaB activity and survival PMID: 20368414
    19. BAG3 is not required for muscle development, this co-chaperone appears to be critically important for maintenance of mature skeletal muscle. PMID: 16936253
    20. The absence of Bis has considerable influences on postnatal growth and survival, possibly due to a nutritional impairment. PMID: 18840758

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 人妻少妇heyzo无码专区| 一本一道波多野结衣一区| 爆乳熟妇一区二区三区| 亚洲va久久久噜噜噜久久4399| av在线亚洲欧洲日产一区二区| 国产97色在线 | 日| 少妇精品揄拍高潮少妇| 少妇精品无码一区二区免费视频| 久久中文字幕人妻熟av女| 国产精品爆乳在线播放第一人称 | 国产综合久久久久久鬼色| 免费无码鲁丝片一区二区| 午夜无码乱码在线观看| 成人午夜亚洲精品无码区毛片| 久久99亚洲精品久久久久| 99久久国产综合精品五月天喷水| 欧美一区二区三区| 人妻中文字幕av无码专区| 2019最新久久久视频精品| 欧美变态另类牲交| 97色精品视频在线观看| 国产精品三级在线观看无码| 国产va免费精品高清在线| 免费va人成视频网站全| 18禁成人黄网站免费观看久久| 国产成人av综合色| 久久综合九色欧美综合狠狠| 国产99久久亚洲综合精品西瓜tv | 国产午夜不卡片免费视频| 欧美xxxx做受欧美88| 国产精品十八禁在线观看| 日本人妻伦在线中文字幕| 亚洲 欧美 自拍 美腿 卡通| 免费无码专区在线视频| 国产精品无码专区| 国产激情久久久久影院老熟女免费| 亚洲精品夜夜夜妓女网| 亚洲国产欧美在线成人aaaa| 中文字幕丰满乱子伦无码专区| 国产精品白浆在线观看免费| 人人莫人人擦人人看|