在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

BRSK1 Antibody

  • 中文名稱:
    BRSK1兔多克隆抗體
  • 貨號:
    CSB-PA990856
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from 293 cells, using BRSK1 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) BRSK1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    BRSK1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human BRSK1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.
  • 基因功能參考文獻:
    1. These results suggest that frameshift mutations of EGR1 and BRSK1 might play a role in tumorigenesis through tumor suppressor gene inactivation in colorectal cancer and gastric cancer. PMID: 27677186
    2. BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 expression. PMID: 25036402
    3. Single nucleotide polymorphism in BRSK1 is associated with the length of reproductive lifespan. PMID: 22131368
    4. acts as checkpoint kinase upon DNA damage induced by UV PMID: 15150265
    5. protein phosphatase 2C is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2. PMID: 18339622
    6. STRADalpha.MO25alpha complexes containing LKB1 variants were equally effective at phosphorylating and activating AMPK, BRSK1, and BRSK2 PMID: 18854318
    7. SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin. PMID: 19648910

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse. Cell junction, synapse, presynaptic active zone. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
  • 蛋白家族:
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
  • 組織特異性:
    Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
  • 數據庫鏈接:

    HGNC: 18994

    OMIM: 609235

    KEGG: hsa:84446

    STRING: 9606.ENSP00000310649

    UniGene: Hs.182081



主站蜘蛛池模板: 亚洲欧洲日产国产 最新| 天下第一社区视频www日本| 国产色情又大又粗又黄的电影| 国精品人妻无码一区二区三区蜜柚| 欧美极品色午夜在线视频| 亚洲精品久久久av无码专区| 色噜噜狠狠色综合av| 欧美无遮挡很黄裸交视频| 韩国三级丰满少妇高潮| 日韩av激情在线观看| 国产sm主人调教女m视频| 国内偷自第一区二区三区| 青青草国产线观看| 天堂网www最新版官网| 色久悠悠婷婷综合在线亚洲| 人妻无码第一区二区三区| 久久人人爽人人爽人人片av高请 | 日本高清一区二区三| .精品久久久麻豆国产精品| 国产精品交换| 老子午夜理论影院理论| 国产欧洲精品自在自线官方 | 亚洲乱亚洲乱妇| 欧美牲交a欧美牲交vdo18| 无码国产激情在线观看| 久久精品人人做人人爱爱漫画| 中文无码乱人伦中文视频在线| 少妇性l交大片毛多| 国产成人卡2卡3卡4乱码| 亚洲综合网站精品一区二区| 国产免费观看久久黄av片| 亚洲精品国产一区二区精华液| а√中文在线资源库| 在线毛片片免费观看| 伊人久久大香线蕉无码不卡| 午夜福利三级理论电影| 国产成人精品综合在线观看 | 人妻色综合网站| 久久精品人妻无码一区二区三区v| 精品亚洲成av人在线观看| 人妻在卧室被老板疯狂进入|