在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. BRSK1 Antibody

BRSK1 Antibody

  • 中文名稱：
    BRSK1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA002821GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    BRSK1
  • 別名：
    BR serine/threonine kinase 1 antibody; BR serine/threonine protein kinase 1 antibody; BR serine/threonine-protein kinase 1 antibody; Brain selective kinase 1 antibody; Brain-specific serine/threonine-protein kinase 1 antibody; BRSK 1 antibody; Brsk1 antibody; BRSK1_HUMAN antibody; FLJ43009 antibody; hSAD1 antibody; KIAA1811 antibody; Protein kinase SAD1A antibody; SAD 1 antibody; SAD1 antibody; SAD1 homolog antibody; SAD1 kinase antibody; SAD1A antibody; SADB antibody; SadB kinase short isoform antibody; Serine/threonine kinase SAD B antibody; Serine/threonine-protein kinase SAD-B antibody; Synapses of Amphids Defective homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human BRSK1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.
  • 基因功能參考文獻(xiàn)：
    1. These results suggest that frameshift mutations of EGR1 and BRSK1 might play a role in tumorigenesis through tumor suppressor gene inactivation in colorectal cancer and gastric cancer. PMID: 27677186
    2. BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 expression. PMID: 25036402
    3. Single nucleotide polymorphism in BRSK1 is associated with the length of reproductive lifespan. PMID: 22131368
    4. acts as checkpoint kinase upon DNA damage induced by UV PMID: 15150265
    5. protein phosphatase 2C is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2. PMID: 18339622
    6. STRADalpha.MO25alpha complexes containing LKB1 variants were equally effective at phosphorylating and activating AMPK, BRSK1, and BRSK2 PMID: 18854318
    7. SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin. PMID: 19648910

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse. Cell junction, synapse, presynaptic active zone. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
  • 組織特異性：
    Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18994

    OMIM: 609235

    KEGG: hsa:84446

    STRING: 9606.ENSP00000310649

    UniGene: Hs.182081



主站蜘蛛池模板： 水蜜桃色314在线观看| 亚洲爆乳aaa无码专区| 国产亚洲精品成人aa片| 国产乱xxxxx97国语对白| 最新69国产成人精品视频免费| 国产日产亚洲系列最新美使用方法 | 国产午夜成人免费看片app| 日韩精品一区二区三区在线观看 | 精品玖玖玖视频在线观看| 午夜成人亚洲理论片在线观看 | 久久久国产精品黄毛片| 亚洲精品一区二区久| 国产熟女亚洲精品麻豆| 精品国产亚洲午夜精品av| 精品人无码一区二区三区| 欧美xxxxx高潮喷水| 人妻无码一区二区三区免费| 2021国产精品国产精华| 色偷偷色噜噜狠狠网站年轻人| 国产农村熟妇videos| 免费看无码毛视频成片| 国产巨大爆乳在线观看| 国产人成无码视频在线1000| 亚洲综合无码一区二区| 少妇高潮太爽了在线观看| 亚洲开心婷婷中文字幕 | 欧美牲交a欧美牲交aⅴ一| 黑人巨茎大战俄罗斯美女| 高潮毛片无遮挡高清免费视频| 久久久综合九色合综| 国内揄拍高清国内精品对白| 成在人线av无码免观看| 欧美大香线蕉线伊人久久| 护士奶头又白又大又好摸视频| 中文字幕日本最新乱码视频| 无码精品国产一区二区免费| 欧美专区另类专区在线视频| 风间由美性色一区二区三区| 亚洲一卡一卡二新区无人区| 精品国产一区二区三区av色诱| 欧美性潮喷xxxxx免费视频看|