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BRD8 Antibody

  • 中文名稱：
    BRD8兔多克隆抗體
  • 貨號(hào)：
    CSB-PA880933LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry analysis of human lung cancer using CSB-PA880933LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) BRD8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    BRD8 antibody; SMAP antibody; SMAP2 antibody; Bromodomain-containing protein 8 antibody; Skeletal muscle abundant protein antibody; Skeletal muscle abundant protein 2 antibody; Thyroid hormone receptor coactivating protein of 120 kDa antibody; TrCP120 antibody; p120 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Bromodomain-containing protein 8 protein (641-859AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，BRD8 Antibody (CSB-PA880933LA01HU)，的標(biāo)記方式是Non-conjugated。對于BRD8 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA880933LB01HU BRD8 Antibody, HRP conjugated ELISA
    FITC CSB-PA880933LC01HU BRD8 Antibody, FITC conjugated
    Biotin CSB-PA880933LD01HU BRD8 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
  • 基因功能參考文獻(xiàn)：
    1. miR-185 can attenuate androgen receptor function indirectly by suppressing BRD8 ISO2 PMID: 26940039
    2. incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma target genes by p400/Brd8 is essential to allow fat cell differentiation PMID: 23064015
    3. SMAP gene family constitutes an important ArfGAP subfamily, with each SMAP member exerting both common and distinct functions in vesicle trafficking. PMID: 16571680
    4. BRD8 expression is associated with tumor progression toward advanced stages PMID: 19787264
  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19874

    OMIM: 602848

    KEGG: hsa:10902

    STRING: 9606.ENSP00000254900

    UniGene: Hs.519337



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