在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

BRAP Antibody, FITC conjugated

  • 中文名稱:
    BRAP兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA773793LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) BRAP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    BRAP antibody; RNF52BRCA1-associated protein antibody; EC 2.3.2.27 antibody; BRAP2 antibody; Impedes mitogenic signal propagation antibody; IMP antibody; RING finger protein 52 antibody; RING-type E3 ubiquitin transferase BRAP2 antibody; Renal carcinoma antigen NY-REN-63 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human BRCA1-associated protein (13-124AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
  • 基因功能參考文獻:
    1. Six polymorphisms (rs12229654 at 12q24.1, rs671 of ALDH2, rs11066015 of ACAD10, rs2074356 and rs11066280 of HECTD4, and rs3782886 of BRAP) were found to be associated with both systolic and diastolic blood pressure, with those at 12q24.1 or in ACAD10 or BRAP being novel determinants of blood pressure in Japanese. PMID: 28562329
    2. IMPACT data were consistent with increased risks of onset among BRCA1 and BRCA2 mutation carriers PMID: 27742670
    3. Expression of BRAP is increased in esophageal squamous cell carcinoma samples compared with non-tumor esophageal tissues; increased expression correlates with reduced patient survival time and promotes metastasis of xenograft tumors in mice. PMID: 28780075
    4. Together the results indicate for the first time that BRAP2 may play an important NRNI role in germ cells of the testis, with an additional, scaffold/structural role in mature spermatozoa. PMID: 25820252
    5. BRAP gene may confer vulnerability for schizophrenia in Han Chinese population. PMID: 24454952
    6. ectopic expression of BRAP2 inhibits nuclear localization of HMG20A and NuMA1, and prevents nuclear envelope accumulation of SYNE2. PMID: 23707952
    7. genetic association studies in population of Chinese Han young adults in Beijing: Data suggest that 2 SNPs in BRAP (rs11066001; rs3782886) are associated with decreased risk of metabolic syndrome in this population. PMID: 22965072
    8. BAP1 expression closely correlates with age, clinical stage, pathologic differentiation and histological type in colorectal cancer (CRC). BAP1 may serve as a novel prognostic biomarker for CRC. PMID: 23526420
    9. Brap2 regulates temporal control of NF-kappaB localization mediated by inflammatory response. PMID: 23554956
    10. The BRAP polymorphism may not play an important role in ischemic stroke in the Taiwanese population. PMID: 23356535
    11. The dominant effect of prolonged USP15 depletion upon signal amplitude is due to a decrease in CRAF levels while allowing for the possibility that USP15 may also function to dampen MAPK signaling through direct stabilization of BRAP. PMID: 23105109
    12. ANRIL on 9p21 and BRAP were both associated with ankle brachial index in a Taiwanese population. PMID: 22122968
    13. Several BRCA1 mutations were observed in Pakistani breast cancer patients with moderate family history. PMID: 22078348
    14. Data show that BRAP conferred a risk for carotid plaque and intima-medial thickness. PMID: 21670849
    15. BRAP gene is associated with the extent of coronary atherosclerosis and has a synergistic effect with diabetes on the occurrence of significant CAD in the Chinese population PMID: 22085839
    16. our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains. PMID: 22022282
    17. Polymorphism of 270 A > G in BRAP is Associated with Lower Ankle-Brachial Index and peripheral artery disease. PMID: 21301165
    18. All results are consistent with BRAP2 being a novel, phosphorylation-regulated negative regulator of nuclear import, with potential as an antiviral agent. PMID: 20040518
    19. Data indicate that one SNP in BRAP showed(rs11066001) a significant association in allele frequency distribution with CAD in both the Japanese and Korean populations. PMID: 19713974
    20. modulates sensitivity of the MAP kinase cascade to stimulus-dependent activation by limiting functional assembly of the core enzymatic components through the inactivation of KSR PMID: 14724641
    21. Monocytic differentiation of the promyelomonocytic cell lines U937 and HL60 is associated with the upregulation of Brap2 expression concomitantly with the upregulation and cytoplasmic relocalization of p21. PMID: 15340083
    22. the capacity of IMP to inhibit signal propagation through Raf to MEK is a consequence of disrupting KSR1 homooligomerization and B-Raf/c-Raf hetero-oligomerization PMID: 18332145
    23. The most current evidence suggests that it may be more beneficial in those with BRCA mutations because tumors associated with these mutations are likely to be estrogen-receptor positive. PMID: 18380995
    24. p21 Ras/Imp regulate cytokine production and migration in CD4 T cells [Imp] PMID: 18577512
    25. Carriers of mutations in the genes BRCA1/2 may present a specific high risk group for PABC especially at younger ages. PMID: 19009954
    26. The authors found that Brap2, which has intrinsic RING domain dependent E3 ligase activity, facilitates HsCdc14A Lys-63 linked ubiquitin modification, indicating that Brap2 may be the ubiquitin E3 Ligase of HsCdc14A. PMID: 19152073
    27. SNPs in BRAP associated with risk of myocardial infarction in Asian populations.BRAP knockdown in cultured coronary endothelial cells suppressed activation of NF-kappaB. PMID: 19198608

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 組織特異性:
    Expressed in breast epithelial cell lines.
  • 數據庫鏈接:

    HGNC: 1099

    OMIM: 604986

    KEGG: hsa:8315

    STRING: 9606.ENSP00000403524

    UniGene: Hs.530940



主站蜘蛛池模板: 日本精品久久久久中文字幕| 国内精品久久久久影院日本| 97碰碰碰人妻无码视频| 在线观看国产精品电影| 狠人干练合综合网| 亚洲va中文字幕无码久久不卡| 国产精品视频二区不卡| 国产精品无码一区二区三区在| 人妻无码视频一区二区三区| av在线亚洲男人的天堂| 天天狠天天透天干天天| 亚洲色无码播放| 轻点好疼好大好爽视频| 国产剧情麻豆女教师在线观看| av色国产色拍| 人狥杂交一区欧美二区| 欧美午夜刺激影院| 99国产精品白浆在线观看免费 | 免费国产高清在线精品一区| 99久热re在线精品99re8热视频| 老司机午夜福利视频| 亚洲精品久久片久久久久| 国产产在线精品亚洲aavv| 人妻少妇中文字幕乱码| 国产做无码视频在线观看浪潮| 欧美506070老妇乱子伦| 亚洲男人成人性天堂网站| 欧美日韩精品| 久久久久久久极品内射| 亚洲旡码a∨一区二区三区| 激情综合婷婷丁香五月蜜桃| 欧美丰满熟妇bbbbbb百度| 无码内射中文字幕岛国片| 真实国产精品vr专区| 色八区人妻在线视频免费| 亚洲人成无码网站久久99热国产| 超碰香蕉人人网99精品| 热久久99这里有精品综合久久| 久久性色av亚洲电影| 久久亚洲一区二区三区四区| 久久久久成人片免费观看r|