在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

BMP10 Antibody

  • 中文名稱:
    BMP10兔多克隆抗體
  • 貨號:
    CSB-PA198870
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from Jurkat cells, using BMP10 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) BMP10 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    BMP10
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from Internal of Human BMP10.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
  • 基因功能參考文獻:
    1. Data suggest BMP9/GDF2 and BMP10 synergize with TNFA to increase monocyte recruitment to vascular endothelial cells; process appears to be mediated mainly via ALK2/ACVR1 (which exhibits protein kinase activity). These studies used in vitro flow monocyte adhesion assay. (BMP9 = growth differentiation factor 2; BMP10 = bone morphogenetic protein 10; TNFA = tumor necrosis factor alpha; ALK2/ACVR1 = activin A receptor type 1) PMID: 28646109
    2. Bone morphogenetic protein (BMP)9 and BMP10 are high affinity ligands for activin receptor-like kinase 1 (ALK1). PMID: 27528761
    3. Forced expression of BMP10 in gastric cancer (GC) cells inhibited its growth and migration, while knocking down the expression of BMP10 in GC cells promoted cell growth, migration, and metastasis. PMID: 26419594
    4. The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells. PMID: 26631724
    5. BMP10, is elevated in the stenotic colon segment of Hirschsprung disease patients, and BMP10 signaling may play a pivotal role in disease development. PMID: 24551273
    6. Low expression of bone morphogenetic protein-10 is associated with urothelial cancer of the bladder. PMID: 23645739
    7. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. PMID: 21737454
    8. Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. PMID: 21550985
    9. Bone morphogenetic protein-10 (BMP-10) may function as a tumor suppressor in breast cancer. PMID: 20608934
    10. Hypertension induced expression of prohypertrophic BMP10, and the hypertrophic effect of BMP10 was modulated, at least in part, by its binding to Tcap at the Z disc. PMID: 17921333
    11. Describes the cloning and expression of murine BMP-10. PMID: 10072785

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    TGF-beta family
  • 組織特異性:
    Detected in mammary epithelia (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20869

    OMIM: 608748

    KEGG: hsa:27302

    STRING: 9606.ENSP00000295379

    UniGene: Hs.158317



主站蜘蛛池模板: 久久综合九色综合97欧美| 人妻无码中文字幕永久在线| 99e热久久免费精品首页| 亚洲成av人无码综合在线观看| 久久久www成人免费毛片| 亚洲gv永久无码天堂网| 久久天天躁狠狠躁夜夜爽| 麻豆av一区二区三区| 无遮挡又爽又刺激的视频| 国产精品一区二区在线蜜芽tv| 久久99精品网久久| 精品午夜福利在线观看| 亚洲最大的成人网站| 人妻丰满熟妇a无码区| 99国产精品欧美一区二区三区 | 欧美激情a∨在线视频播放| 全部孕妇毛片| 清纯唯美经典一区二区| 亚洲成av人片在线观看无| 动漫精品啪啪一区二区三区| 18处破外女出血在线| 欧美成人高清视频a在线看| 亚洲国产一区二区三区在线观看| 伊人蕉久中文字幕无码专区| 亚洲亚洲人成无码网www| 天天躁人人躁人人躁狂躁| 呦系列视频一区二区三区| 亚洲人成无码网www电影榴莲| 50岁熟妇的呻吟声对白| 国产精品亚洲综合色区韩国| 国产aⅴ激情无码久久久无码| 亚洲人成网站18禁止大| 国产精品无码久久久久久| 中文字幕乱妇无码av在线| 国产精品乱子伦xxxx裸| 伊人久久精品无码av一区| 国产乱码精品一区二区三区中文 | 国产精品夜色一区二区三区| 高h纯肉无码视频在线观看| 黑人巨大videos精品| 2020国产在线拍揄自揄视频|