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  4. BCDIN3D Antibody, HRP conjugated

BCDIN3D Antibody, HRP conjugated

  • 中文名稱：
    BCDIN3D兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA767206LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) BCDIN3D Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    BCDIN3D
  • 別名：
    BCDIN3 domain containing antibody; BCDIN3 domain-containing protein antibody; BCDIN3D antibody; BN3D2_HUMAN antibody; Probable methyltransferase BCDIN3D antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Pre-miRNA 5'-monophosphate methyltransferase protein (1-292AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.
  • 基因功能參考文獻：
    1. BCDIN3D might serve as an important prognostic factor for triple-negative breast cancer PMID: 27259993
    2. BCDIN3D acts as a cytoplasmic tRNAHis-specific 5-methylphosphate capping enzyme. PMID: 28119416
    3. Human BCDIN3D monomethylates the 5'-monophosphate of cytoplasmic tRNAHis in vitro. In BCDN3D-knockout cells, established byCRISPR/Cas9 editing, the methyl moiety at the 5'-monophosphate of cytoplasmic tRNAHis is lost, and the exogenous expression of BCDIN3D in the knockout cells restores the modification in cytoplasmic tRNAHis. PMID: 28119416
    4. BCDIN3D depletion leads to lower pre-miR-145 and concomitantly increased mature miR-145 levels in breast cancer cells, which suppresses their tumorigenic phenotypes. PMID: 23063121
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Methyltransferase superfamily
  • 數據庫鏈接：

    HGNC: 27050

    KEGG: hsa:144233

    STRING: 9606.ENSP00000335201

    UniGene: Hs.142736



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