在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. BATF Antibody

BATF Antibody

  • 中文名稱：
    BATF兔多克隆抗體
  • 貨號：
    CSB-PA002570GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    BATF
  • 別名：
    Activating transcription factor B antibody; B ATF antibody; B-ATF antibody; B-cell-activating transcription factor antibody; Basic leucine zipper transcription factor like antibody; Basic leucine zipper transcriptional factor ATF like antibody; Basic leucine zipper transcriptional factor ATF-like antibody; Batf antibody; BATF_HUMAN antibody; BATF1 antibody; SF HT activated gene 2 protein antibody; SF-HT-activated gene 2 protein antibody; SFA 2 antibody; SFA-2 antibody; SFA2 antibody
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human BATF
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs.
  • 基因功能參考文獻：
    1. Findings demonstrate that peripheral and intrahepatic BATF expressions are dramatically increased in chronic hepatitis B (CHB) patients, which might boost the differentiation of Th17 cells and the release of associated cytokine during chronic HBV infection. PMID: 29164410
    2. BATF plays a key role in the differentiation of T helper cell subsets and Ig class-switching. Apart from that we suggest an important function in mast cell development and in murine models of allergic asthma, it was observed that mice deficient for Batf are protected from the disease. Hence, the previous findings on BATF make it an interesting target for the treatment of Th cell-derived-cytokine-driven diseases. PMID: 26970726
    3. Retinoic acid signaling and BATF productions are activated in IgAN patients compared with controls. PMID: 27073891
    4. BATF/JUN-B and BATF/C-JUN complexes play important roles in OA cartilage destruction through regulating anabolic and catabolic gene expression in chondrocytes. PMID: 27147707
    5. Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung PMID: 25491772
    6. data strongly support a model in which EBNA3A is tethered to DNA through a BATF-containing protein complexes to enable continuous cell proliferation PMID: 25540416
    7. increase expression in children with recurrent asthma PMID: 24290279
    8. The activator protein 1 (AP1) family transcription factor BATF (B cell, activating transcription factor-like) was among the genes enriched in Th9 cells and was required for the expression of IL-9 and other Th9-associated genes. PMID: 24216482
    9. PD-1 inhibits T cell function by upregulating BATF. PMID: 20890291
    10. Overexpression of human BATF in transgenic mice disrupts the development of thymus-derived NKT cells PMID: 12594265
    11. up-regulated dramatically within 24 h following the infection of established and primary human B cells with EBV by the action of EBNA2 and activated Notch protein PMID: 12719594
    12. Phosphorylation of serine-43 converts BATF from a DNA binding into a non-DNA binding inhibitor of activator protein-1 activity. PMID: 12809553

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    BZIP family
  • 組織特異性：
    Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expres
  • 數據庫鏈接：

    HGNC: 958

    OMIM: 612476

    KEGG: hsa:10538

    STRING: 9606.ENSP00000286639

    UniGene: Hs.509964



主站蜘蛛池模板： 亚洲精品网站在线观看你懂的| 久久成人影院精品99| 亚洲性色成人av| 成人午夜亚洲精品无码区| 无码一区二区三区亚洲人妻| 内射少妇一区27p| 国产激情з∠视频一区二区| 欧美一区二区三区激情| 亚洲国产午夜精华无码福利| 成人黄网站高清免费视频| 成熟妇女性成熟满足视频| 亚洲国产一区二区三区波多野结衣| 久久精品中文无码资源站| 亚洲2020天天堂在线观看 | 国产美女爽到尿喷出来视频| 亚洲国产成人精品激情姿源 | 久久99亚洲精品久久99果| 亚洲另类无码专区国内精品| 日本黄漫动漫在线观看视频| 欧美人与zoxxxx另类| 国产又黄又硬又粗| 欧美丰满少妇xxxx性| 超碰国产天天做天天爽| 国产爽视频在线观看视频| 无卡无码无免费毛片| 国产精品久久久久久久| 骚女人干起来舒服视频在线| 国产一卡二卡三新区2022| 亚洲精品一区久久久久一品av| 久久综合99re88久久爱| 神马午夜福利不卡片在线| 国产成人精品高清在线观看93| 在线精品国产成人综合| 五十路熟妇亲子交尾| 让少妇高潮无乱码高清在线观看| 午夜精品久久久久久久99老熟妇| 国产成人久久精品流白浆| 在线不卡日本v一区二区| 在线观看国产精品乱码app| 欧美性受xxxx白人性爽| 窝窝影院午夜看片|