在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. BATF Antibody

BATF Antibody

  • 中文名稱：
    BATF兔多克隆抗體
  • 貨號：
    CSB-PA002570GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    BATF
  • 別名：
    Activating transcription factor B antibody; B ATF antibody; B-ATF antibody; B-cell-activating transcription factor antibody; Basic leucine zipper transcription factor like antibody; Basic leucine zipper transcriptional factor ATF like antibody; Basic leucine zipper transcriptional factor ATF-like antibody; Batf antibody; BATF_HUMAN antibody; BATF1 antibody; SF HT activated gene 2 protein antibody; SF-HT-activated gene 2 protein antibody; SFA 2 antibody; SFA-2 antibody; SFA2 antibody
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human BATF
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs.
  • 基因功能參考文獻：
    1. Findings demonstrate that peripheral and intrahepatic BATF expressions are dramatically increased in chronic hepatitis B (CHB) patients, which might boost the differentiation of Th17 cells and the release of associated cytokine during chronic HBV infection. PMID: 29164410
    2. BATF plays a key role in the differentiation of T helper cell subsets and Ig class-switching. Apart from that we suggest an important function in mast cell development and in murine models of allergic asthma, it was observed that mice deficient for Batf are protected from the disease. Hence, the previous findings on BATF make it an interesting target for the treatment of Th cell-derived-cytokine-driven diseases. PMID: 26970726
    3. Retinoic acid signaling and BATF productions are activated in IgAN patients compared with controls. PMID: 27073891
    4. BATF/JUN-B and BATF/C-JUN complexes play important roles in OA cartilage destruction through regulating anabolic and catabolic gene expression in chondrocytes. PMID: 27147707
    5. Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung PMID: 25491772
    6. data strongly support a model in which EBNA3A is tethered to DNA through a BATF-containing protein complexes to enable continuous cell proliferation PMID: 25540416
    7. increase expression in children with recurrent asthma PMID: 24290279
    8. The activator protein 1 (AP1) family transcription factor BATF (B cell, activating transcription factor-like) was among the genes enriched in Th9 cells and was required for the expression of IL-9 and other Th9-associated genes. PMID: 24216482
    9. PD-1 inhibits T cell function by upregulating BATF. PMID: 20890291
    10. Overexpression of human BATF in transgenic mice disrupts the development of thymus-derived NKT cells PMID: 12594265
    11. up-regulated dramatically within 24 h following the infection of established and primary human B cells with EBV by the action of EBNA2 and activated Notch protein PMID: 12719594
    12. Phosphorylation of serine-43 converts BATF from a DNA binding into a non-DNA binding inhibitor of activator protein-1 activity. PMID: 12809553

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    BZIP family
  • 組織特異性：
    Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expres
  • 數據庫鏈接：

    HGNC: 958

    OMIM: 612476

    KEGG: hsa:10538

    STRING: 9606.ENSP00000286639

    UniGene: Hs.509964



主站蜘蛛池模板： 国产福利视频在线观看| 亚洲性夜夜综合久久7777| 无码专区―va亚洲v专区在线 | 国产精品久久久久久2021| 精品国产三级在线观看| 西西444www无码大胆| 337p人体 欧洲人体 亚洲 | 不卡av电影在线| 久久精品夜色噜噜亚洲a∨| 成 人色 网 站 欧美大片在线观看| 免费国产精品视频在线| 熟妇的奶头又大又粗视频| 丰满人妻熟妇乱偷人无码| 伊人狠狠色丁香婷婷综合| 免费的av网站在线观看国产精品| 97夜夜澡人人双人人人喊| 国产又色又爽又黄的免费| 国产69精品久久久久999小说| 日韩人妻无码精品免费shipin| 国产在线精品一区二区在线看| 一区二区三区四区在线 | 欧洲| 九九re6热在线视频精品66| 特级毛片爽www免费版| 中文乱码人妻系列一区| 欧洲精品va无码一区二区三区| 自拍偷自拍亚洲精品第1页| 久久精品人妻无码一区二区三区| 永久免费观看美女裸体的网站| 国产亚洲精品福利视频在线观看 | 一本久道中文无码字幕av| 在线视频免费观看爽爽爽| 1区2区3区高清视频| 国产精品午夜视频自在拍| 免费观看美女裸体网站| 免费人成视频x8x8入口| 欧美毛多水多黑寡妇| 国产精品一区二区av片| 亚洲午夜成人av电影| 又紧又大又爽精品一区二区| 亚洲a∨国产av综合av网站| 玖玖资源站无码专区|