在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. BATF Antibody

BATF Antibody

  • 中文名稱：
    BATF兔多克隆抗體
  • 貨號(hào)：
    CSB-PA109532
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using BATF antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) BATF Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    BATF
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human BATF.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs.
  • 基因功能參考文獻(xiàn)：
    1. Findings demonstrate that peripheral and intrahepatic BATF expressions are dramatically increased in chronic hepatitis B (CHB) patients, which might boost the differentiation of Th17 cells and the release of associated cytokine during chronic HBV infection. PMID: 29164410
    2. BATF plays a key role in the differentiation of T helper cell subsets and Ig class-switching. Apart from that we suggest an important function in mast cell development and in murine models of allergic asthma, it was observed that mice deficient for Batf are protected from the disease. Hence, the previous findings on BATF make it an interesting target for the treatment of Th cell-derived-cytokine-driven diseases. PMID: 26970726
    3. Retinoic acid signaling and BATF productions are activated in IgAN patients compared with controls. PMID: 27073891
    4. BATF/JUN-B and BATF/C-JUN complexes play important roles in OA cartilage destruction through regulating anabolic and catabolic gene expression in chondrocytes. PMID: 27147707
    5. Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung PMID: 25491772
    6. data strongly support a model in which EBNA3A is tethered to DNA through a BATF-containing protein complexes to enable continuous cell proliferation PMID: 25540416
    7. increase expression in children with recurrent asthma PMID: 24290279
    8. The activator protein 1 (AP1) family transcription factor BATF (B cell, activating transcription factor-like) was among the genes enriched in Th9 cells and was required for the expression of IL-9 and other Th9-associated genes. PMID: 24216482
    9. PD-1 inhibits T cell function by upregulating BATF. PMID: 20890291
    10. Overexpression of human BATF in transgenic mice disrupts the development of thymus-derived NKT cells PMID: 12594265
    11. up-regulated dramatically within 24 h following the infection of established and primary human B cells with EBV by the action of EBNA2 and activated Notch protein PMID: 12719594
    12. Phosphorylation of serine-43 converts BATF from a DNA binding into a non-DNA binding inhibitor of activator protein-1 activity. PMID: 12809553

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    BZIP family
  • 組織特異性：
    Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expres
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 958

    OMIM: 612476

    KEGG: hsa:10538

    STRING: 9606.ENSP00000286639

    UniGene: Hs.509964



主站蜘蛛池模板： 久久久久人妻一区二区三区| 亚洲精品久久久久高潮| 日韩免费码中文在线观看| 天天综合色天天综合色hd| 大胆欧美熟妇xxbbwwbw高潮了| 中文在线中文资源| 亚洲高清国产av拍精品青青草原| 亚洲男人的天堂成人www| 扒开双腿疯狂进出爽爽爽视频 | av制服丝袜白丝国产网站| 欧美丰满熟妇xxxx性大屁股| 日韩精品无码一区二区| 久久久久久成人综合网| 国产精品18禁污污网站| 唐人社导航福利精品| 久久亚洲精品无码播放| 他用舌头给我高潮喷水在线 | 国产内射999视频一区| 狠狠色狠狠色五月激情| 国内老熟妇乱子伦视频 | 爆乳2把你榨干哦ova在线观看| 天天弄天天模| 亚洲国产成在人网站天堂| 蜜桃麻豆www久久国产sex| 国产三级在线观看完整版| 真人祼交二十三式视频| 国产偷窥熟精品视频| 男人靠女人的免费视频| 精品国产sm最大网免费站| 国产乱子伦精品免费无码专区| 精品人伦一区二区三区潘金莲| 精品无码久久久久久久久久| 国产精品久久国产精品99 gif| 日韩精品一区二区三区在线观看l 亚洲在av人极品无码 | 亚洲成a人片在线观看中文| 日产乱码一区二区三区在线| 欧美大波少妇在厨房被| 狠狠97人人婷婷五月| 久久精品国产99久久丝袜蜜桃| 中日韩va无码中文字幕| 亚洲春色在线视频|