在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. BATF Antibody

BATF Antibody

  • 中文名稱：
    BATF兔多克隆抗體
  • 貨號(hào)：
    CSB-PA109532
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using BATF antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) BATF Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    BATF
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human BATF.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs.
  • 基因功能參考文獻(xiàn)：
    1. Findings demonstrate that peripheral and intrahepatic BATF expressions are dramatically increased in chronic hepatitis B (CHB) patients, which might boost the differentiation of Th17 cells and the release of associated cytokine during chronic HBV infection. PMID: 29164410
    2. BATF plays a key role in the differentiation of T helper cell subsets and Ig class-switching. Apart from that we suggest an important function in mast cell development and in murine models of allergic asthma, it was observed that mice deficient for Batf are protected from the disease. Hence, the previous findings on BATF make it an interesting target for the treatment of Th cell-derived-cytokine-driven diseases. PMID: 26970726
    3. Retinoic acid signaling and BATF productions are activated in IgAN patients compared with controls. PMID: 27073891
    4. BATF/JUN-B and BATF/C-JUN complexes play important roles in OA cartilage destruction through regulating anabolic and catabolic gene expression in chondrocytes. PMID: 27147707
    5. Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung PMID: 25491772
    6. data strongly support a model in which EBNA3A is tethered to DNA through a BATF-containing protein complexes to enable continuous cell proliferation PMID: 25540416
    7. increase expression in children with recurrent asthma PMID: 24290279
    8. The activator protein 1 (AP1) family transcription factor BATF (B cell, activating transcription factor-like) was among the genes enriched in Th9 cells and was required for the expression of IL-9 and other Th9-associated genes. PMID: 24216482
    9. PD-1 inhibits T cell function by upregulating BATF. PMID: 20890291
    10. Overexpression of human BATF in transgenic mice disrupts the development of thymus-derived NKT cells PMID: 12594265
    11. up-regulated dramatically within 24 h following the infection of established and primary human B cells with EBV by the action of EBNA2 and activated Notch protein PMID: 12719594
    12. Phosphorylation of serine-43 converts BATF from a DNA binding into a non-DNA binding inhibitor of activator protein-1 activity. PMID: 12809553

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    BZIP family
  • 組織特異性：
    Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expres
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 958

    OMIM: 612476

    KEGG: hsa:10538

    STRING: 9606.ENSP00000286639

    UniGene: Hs.509964



主站蜘蛛池模板： 日韩人妻无码精品系列专区| 亚洲人成网77777色在线播放 | 亚洲国产精品无码一线岛国| 少妇的肉体k8经典| 成人无码在线视频网站| 日韩 亚洲 欧美 国产 精品| 久99久热只有精品国产15| 自拍性旺盛老熟女| 无码午夜成人1000部免费视频| 亚洲色大成网站www永久麻豆| 国产av国内精品jk制服| 丁香五月亚洲中文字幕| 国产乱子伦一区二区三区四区五区| 粉嫩大学生无套内射无码卡视频 | 风韵少妇性饥渴推油按摩视频| 五月开心播播网| 国内精品视这里只有精品| 久久婷婷五月综合中文字幕 | 国产精品99精品久久免费| 亚洲色成人网站www永久四虎| 与子敌伦刺激对白播放的优点| 国产精品成人免费999| 日韩成人无码v清免费| 欧美国产日韩a在线视频下载| 欧美老熟妇乱子伦视频| 久久亚洲国产成人影院| 久久人妻国产精品| 久久人人97超碰caoporen| 人人澡人人妻人人爽人人蜜桃| 无码av大香线蕉伊人久久| 羞羞色男人的天堂| 人妻精品久久无码区| 国产成人无码一二三区视频 | 亚洲国产精品久久久久久| 日本久久综合久久综合| 日韩在线 | 中文| 无尺码精品产品网站| 一个人在线观看免费中文www| 久久久综合九色综合88| 亚洲日韩a∨无码久| 国产女人水真多18毛片18精品|