在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. BAI1 Antibody

BAI1 Antibody

  • 中文名稱：
    BAI1兔多克隆抗體
  • 貨號：
    CSB-PA172172
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA172172(BAI1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA172172(BAI1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    B830018M07Rik antibody; BAI 1 antibody; BAI1 antibody; BAI1_HUMAN antibody; Brain specific angiogenesis inhibitor 1 antibody; Brain-specific angiogenesis inhibitor 1 antibody; GDAIF antibody; KIAA4089 antibody; mKIAA4089 antibody; R75078 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human BAI1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity. In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells. Promotes myoblast fusion. Activates the Rho pathway in a G-protein-dependent manner. Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity. Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1. Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma.; Inhibits angiogenesis in a CD36-dependent manner.; Inhibits angiogenesis.
  • 基因功能參考文獻：
    1. We have uncovered a new role for BAI1 in facilitating macrophage anti-viral responses. We show that arming oHSV with antiangiogenic Vstat120 also shields them from inflammatory macrophage antiviral response, without reducing safety PMID: 27852701
    2. Data suggest agonist-induced signal transduction via either BAI1/ADGRB1 or GPR56/ADGRG1 does not require conserved membrane-proximal stalk region; thus, it appears GAIN domain cleavage via autoproteolysis is not necessary for receptor activation. PMID: 26710850
    3. BAI1 may be involved in the negative regulation of bladder transitional cell carcinoma microvascular proliferation, and its expression may be associated with a reduction in p53 mutations. PMID: 26129954
    4. Results show that lower BAI1 expression correlates with poorer patient survival, and high Nestin expression is associated with an increased probability of metastases in breast cancer patients. PMID: 25376607
    5. recognition of apoptotic cells by BAI1 contributes to their clearance in the human gastric mucosa and this is associated with anti-inflammatory effects PMID: 24509909
    6. findings demonstrate that BAI1 is a synaptic receptor that can activate both the Rho and ERK pathways, with the N-terminal and C-terminal regions of the receptor playing key roles in the regulation of BAI1 signaling activity PMID: 23782696
    7. The results of this study indicated that BAI1 plays an important role in synaptogenesis that is mechanistically distinct from its role in phagocytosis. PMID: 23595754
    8. Proprotein convertases, primarily furin, activate latent matrix metalloproteinase-14, which then directly cleaves BAI1 to release the bioactive fragment. PMID: 22330140
    9. MBD2 overexpression during gliomagenesis may drive tumor growth by suppressing the antiangiogenic activity of a key tumor BAI1. PMID: 21724586
    10. brain-specific angiogenesis inhibitor 1 over-expression suppresses tumour angiogenesis PMID: 11875720
    11. BAI1 was expressed in cerebral neurons but not astrocytes. It was localized in the cytoplasm and cell membrane. BAI1 protein may play an important role in synapse formation and signal transduction PMID: 12074842
    12. BAI1 was widely expressed in normal brain but was absent in 28 glioma cell lines and in the majority of human glioblastoma investigated. BAI1 expression did not correlate with TP53 status PMID: 12507886

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, phagocytic cup. Cell junction, focal adhesion. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density.; [Vasculostatin-120]: Secreted.; [Vasculostatin-40]: Secreted.
  • 蛋白家族：
    G-protein coupled receptor 2 family, LN-TM7 subfamily
  • 組織特異性：
    Expressed in brain (at protein level). Expressed on mononuclear phagocytes and monocyte-derived macrophages in the gastric mucosa (at protein level). Expressed in normal pancreatic tissue but not in pancreatic tumor tissue. Reduced or no expression is obs
  • 數據庫鏈接：

    HGNC: 943

    OMIM: 602682

    KEGG: hsa:575

    STRING: 9606.ENSP00000313046

    UniGene: Hs.194654



主站蜘蛛池模板： 色婷婷欧美在线播放内射| 免费中文字幕日韩欧美| 少妇三级全黄| 日日噜噜夜夜狠狠久久丁香五月| 亚洲区欧美区综合区自拍区| 日本一二免费不卡区| 亚洲欧美自拍制服另类图区| 毛片大全真人在线| √天堂资源在线中文8在线最新版| 人妻无码第一区二区三区| 一区二区三区视频| 成人亚洲a片v一区二区三区日本| 国产如狼似虎富婆找强壮黑人| 久久大香线蕉国产精品免费| 青青草原亚洲| 国产精品99久久精品爆乳| 国产熟妇勾子乱视频| 亚洲a∨国产av综合av网站| 国产在线清纯极品美女援交| 亚洲乱色熟女一区二区三区丝袜 | 亚洲熟悉妇女xxx妇女av| 日韩国产亚洲欧美中国v| 亚洲 一区二区 在线| 精品无码专区亚洲| 国产人久久人人人人爽| 成人性生交大片免费看96| 精品国产一区二区av麻豆不卡| 亚洲精品久久一区二区无卡| 久久久久久人妻精品一区| 欧美不卡一区二区三区| 曰韩少妇内射免费播放| 亚洲欧美日韩视频高清专区 | 国产小屁孩cao大人免费| 日韩人妻一区二区三区免费| 国产成人综合久久三区| 99久e在线精品视频在线| 成人区人妻精品一区二区不卡网站 | 亚洲日韩欧美一区二区三区| 色一情一乱一伦| 四虎国产精品永久免费网址 | 亚洲小说区图片区另类春色|