在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. BAI1 Antibody

BAI1 Antibody

  • 中文名稱：
    BAI1兔多克隆抗體
  • 貨號：
    CSB-PA013118
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA013118(BAI1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA013118(BAI1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    B830018M07Rik antibody; BAI 1 antibody; BAI1 antibody; BAI1_HUMAN antibody; Brain specific angiogenesis inhibitor 1 antibody; Brain-specific angiogenesis inhibitor 1 antibody; GDAIF antibody; KIAA4089 antibody; mKIAA4089 antibody; R75078 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human BAI1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity. In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells. Promotes myoblast fusion. Activates the Rho pathway in a G-protein-dependent manner. Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity. Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1. Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma.; Inhibits angiogenesis in a CD36-dependent manner.; Inhibits angiogenesis.
  • 基因功能參考文獻：
    1. We have uncovered a new role for BAI1 in facilitating macrophage anti-viral responses. We show that arming oHSV with antiangiogenic Vstat120 also shields them from inflammatory macrophage antiviral response, without reducing safety PMID: 27852701
    2. Data suggest agonist-induced signal transduction via either BAI1/ADGRB1 or GPR56/ADGRG1 does not require conserved membrane-proximal stalk region; thus, it appears GAIN domain cleavage via autoproteolysis is not necessary for receptor activation. PMID: 26710850
    3. BAI1 may be involved in the negative regulation of bladder transitional cell carcinoma microvascular proliferation, and its expression may be associated with a reduction in p53 mutations. PMID: 26129954
    4. Results show that lower BAI1 expression correlates with poorer patient survival, and high Nestin expression is associated with an increased probability of metastases in breast cancer patients. PMID: 25376607
    5. recognition of apoptotic cells by BAI1 contributes to their clearance in the human gastric mucosa and this is associated with anti-inflammatory effects PMID: 24509909
    6. findings demonstrate that BAI1 is a synaptic receptor that can activate both the Rho and ERK pathways, with the N-terminal and C-terminal regions of the receptor playing key roles in the regulation of BAI1 signaling activity PMID: 23782696
    7. The results of this study indicated that BAI1 plays an important role in synaptogenesis that is mechanistically distinct from its role in phagocytosis. PMID: 23595754
    8. Proprotein convertases, primarily furin, activate latent matrix metalloproteinase-14, which then directly cleaves BAI1 to release the bioactive fragment. PMID: 22330140
    9. MBD2 overexpression during gliomagenesis may drive tumor growth by suppressing the antiangiogenic activity of a key tumor BAI1. PMID: 21724586
    10. brain-specific angiogenesis inhibitor 1 over-expression suppresses tumour angiogenesis PMID: 11875720
    11. BAI1 was expressed in cerebral neurons but not astrocytes. It was localized in the cytoplasm and cell membrane. BAI1 protein may play an important role in synapse formation and signal transduction PMID: 12074842
    12. BAI1 was widely expressed in normal brain but was absent in 28 glioma cell lines and in the majority of human glioblastoma investigated. BAI1 expression did not correlate with TP53 status PMID: 12507886

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, phagocytic cup. Cell junction, focal adhesion. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density.; [Vasculostatin-120]: Secreted.; [Vasculostatin-40]: Secreted.
  • 蛋白家族：
    G-protein coupled receptor 2 family, LN-TM7 subfamily
  • 組織特異性：
    Expressed in brain (at protein level). Expressed on mononuclear phagocytes and monocyte-derived macrophages in the gastric mucosa (at protein level). Expressed in normal pancreatic tissue but not in pancreatic tumor tissue. Reduced or no expression is obs
  • 數據庫鏈接：

    HGNC: 943

    OMIM: 602682

    KEGG: hsa:575

    STRING: 9606.ENSP00000313046

    UniGene: Hs.194654



主站蜘蛛池模板： 国产午夜高清高清在线观看| 中文幕无线码中文字蜜桃| 2021年国产精品专区丝袜| 久久久774这里只有精品17| 日本动漫瀑乳h动漫啪啪免费| 亚洲aⅴ男人的天堂在线观看| 窝窝影院午夜看片| 国内外精品激情刺激在线 | 国产日产欧产精品| 亚洲h成年动漫在线观看网站 | 噜噜久久噜噜久久鬼88| 日本三级吃奶头添泬无码苍井空| 国产亚洲色婷婷久久99精品 | 午夜男女无遮掩免费视频| 成人无码av一区二区| 久久精品国产99国产精品澳门| 久久久综合香蕉尹人综合网 | 狠狠躁日日躁夜夜躁2020| 欧美精品1卡二卡三卡四卡| 欧美性猛交内射兽交老熟妇| 老熟女高潮一区二区三区 | 2021国产精品午夜久久| 国产高清在线精品一区| 亚洲国产一卡2卡3卡4卡5公司 | 高潮内射双龙视频| 免费毛儿一区二区十八岁| 亚洲精品国产一区二区贰佰信息网| 无遮挡十八禁污污网站免费| 人人爽人人爽人人片a免费| 欧美黑人乱大交| 国产精品无码mv在线观看| 免费两性的视频网站| 毛片内射-百度| 久久精品人妻一区二区蜜桃| 新国产精品视频福利免费| 亚洲va中文字幕无码一二三区| 国产成人久久精品二区三区| 久久www香蕉免费人成| 老汉老妇姓交视频| 日日碰狠狠躁久久躁| 337p西西人体大胆瓣开下部|