在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Angptl8 Antibody

  • 中文名稱:
    Angptl8兔多克隆抗體
  • 貨號:
    CSB-PA844436LA01MO
  • 規格:
    ¥440
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Mus musculus (Mouse) Angptl8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Angptl8 antibody; Gm6484 antibody; RiflAngiopoietin-like protein 8 antibody; Betatrophin antibody; Lipasin antibody; Refeeding-induced fat and liver protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Mouse
  • 免疫原:
    Recombinant Mouse Betatrophin protein (16-198AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,Angptl8 Antibody (CSB-PA844436LA01MO),的標記方式是Non-conjugated。對于Angptl8 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA844436LB01MO Angptl8 Antibody, HRP conjugated ELISA
    FITC CSB-PA844436LC01MO Angptl8 Antibody, FITC conjugated
    Biotin CSB-PA844436LD01MO Angptl8 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state. According to a report, may act by promoting ANGPTL3 cleavage. According to another study, not required for cleavage of ANGPTL3.
  • 基因功能參考文獻:
    1. ANGPTL8 has a functional LPL inhibitory motif, but only inhibits LPL and increases plasma TG levels in mice in the presence of ANGPTL3 PMID: 28413163
    2. knock-down of Angptl8 in adipocytes suggests that the protein acts to inhibit intracellular lipolysis, analogous to its activity in the circulation. Depletion of Angptl8 results in an altered cellular phospholipid composition. The findings identify Angptl8 as a central insulin-regulated controller of adipocyte lipid metabolism. PMID: 28528274
    3. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition. PMID: 27469268
    4. Obesity is associated with increased betatrophin suppression after an oral glucose load; this response appears to be driven by hyperglycemia. Data suggest that insulin or low glucose (as in hypoglycemia) increases betatrophin expression/secretion in adipocytes (3T3-L1 cells here); elevation of glucose levels blunts this effect. PMID: 27459526
    5. circulating betatrophin is increased in mice and humans with NAFLD and its expression was induced by endoplasmic reticulum stress in hepatocytes PMID: 27045862
    6. The expression of betatrophin is upregulated in the liver, white adipose tissue (WAT) and brown adipose tissue in obese hyperinsulinemic type 2 diabetes but decreased in WAT in hypoinsulinemic type 1 diabetes, suggesting its positive correlation with body weight and plasma insulin but not blood glucose. PMID: 27097546
    7. This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 and Angptl4 at different nutritional statuses. PMID: 26687026
    8. ANGPTL8 is a stress-response protein that down-regulates expression of ATGL. PMID: 26569053
    9. no substantial change in beta cell replication, mass or glucose homeostasis was observed following ANGPTL8 overexpression PMID: 25917759
    10. A monoclonal antibody against Angptl8, a feeding-induced hepatokine, lowers serum triglyceride levels when injected into mice. Angptl8 inhibits the activity of lipoprotein lipase in cardiac and skeletal muscle, but not in white adipose tissue. Therefore, Angptl8 acts, at least in part, in an endocrine manner, and its inhibition has therapeutical potential in treating hypertriglyceridemia. PMID: 26687026
    11. ANGPTL8 is not required for beta cell function or the compensatory beta cell growth response to insulin resistance, overexpression of ANGPTL8 does not increase beta cell area nor improve glycemic control, and ANGPTL8 regulates plasma triglyceride levels. PMID: 25417115
    12. Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. PMID: 24043787
    13. These results suggest Lipasin and some ANGPTLs play distinct physiological roles in mediating thermogenesis and energy homeostasis. PMID: 23261442
    14. Lipasin is a novel but atypical member of the angiopoietin-like protein family. PMID: 23261442
    15. Lipasin is thus a novel nutritionally-regulated liver-enriched factor that plays a role in lipid metabolism. PMID: 22809513
    16. RIFL is an important new regulator of lipid metabolism. PMID: 22569073

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    ANGPTL8 family
  • 組織特異性:
    Expressed in liver and fat. Enriched in white and brown adipose tissues.
  • 數據庫鏈接:


主站蜘蛛池模板: 我的公把我弄高潮了视频| 日韩精品专区在线影院重磅| 久热爱精品视频线路一| 亚洲一区二区三区含羞草| 无码人妻少妇伦在线电影| 国产精品国产三级在线专区| 午夜美女裸体福利视频| 精品日本一区二区免费视频| 护士av无码在线观看| 亚洲人成电影网站在线观看| 麻豆传传媒久久久爱| 最新精品国偷自产在线| 亚洲色大网站www永久网站| 亚洲成αv人片在线观看| 三级做爰高清视频| 亚洲色大成网站www国产| 香蕉久久一区二区三区啪啪| 亚洲伊人久久大香线蕉| 国产超碰人人做人人爱| 亚洲最大成人网站| 国产av无码专区亚洲awww| 欧美黑人异族videos| 成年免费视频黄网站在线观看| 国产精品.xx视频.xxtv| 无码精品一区二区三区在线| 中文人妻av久久人妻水密桃| 精品亚洲成a人片在线观看| 久久97精品久久久久久久不卡| 亚洲最大的成人网| 国产av国片偷人妻麻豆| 欧洲vat一区二区三区| 亚洲一线二线三线品牌精华液久久久| 国产无遮挡又黄又爽在线观看| 无码人妻精品一区二区| 无码精品国产dvd在线观看9久| 无码三级国产三级在线电影| 性xxxx欧美老妇胖老太性多毛 | 欧美国产综合欧美视频| 樱花草在线社区www日本影院| 国产免费高清69式视频在线观看| 伊人久久大香线蕉av色婷婷色|