在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Angptl8 Antibody, Biotin conjugated

  • 中文名稱(chēng):
    Angptl8兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào):
    CSB-PA844436LD01MO
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng):
    Rabbit anti-Mus musculus (Mouse) Angptl8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Angptl8 antibody; Gm6484 antibody; RiflAngiopoietin-like protein 8 antibody; Betatrophin antibody; Lipasin antibody; Refeeding-induced fat and liver protein antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Mouse
  • 免疫原:
    Recombinant Mouse Betatrophin protein (16-198AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標(biāo)記方式:
    Biotin
  • 克隆類(lèi)型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state. According to a report, may act by promoting ANGPTL3 cleavage. According to another study, not required for cleavage of ANGPTL3.
  • 基因功能參考文獻(xiàn):
    1. ANGPTL8 has a functional LPL inhibitory motif, but only inhibits LPL and increases plasma TG levels in mice in the presence of ANGPTL3 PMID: 28413163
    2. knock-down of Angptl8 in adipocytes suggests that the protein acts to inhibit intracellular lipolysis, analogous to its activity in the circulation. Depletion of Angptl8 results in an altered cellular phospholipid composition. The findings identify Angptl8 as a central insulin-regulated controller of adipocyte lipid metabolism. PMID: 28528274
    3. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition. PMID: 27469268
    4. Obesity is associated with increased betatrophin suppression after an oral glucose load; this response appears to be driven by hyperglycemia. Data suggest that insulin or low glucose (as in hypoglycemia) increases betatrophin expression/secretion in adipocytes (3T3-L1 cells here); elevation of glucose levels blunts this effect. PMID: 27459526
    5. circulating betatrophin is increased in mice and humans with NAFLD and its expression was induced by endoplasmic reticulum stress in hepatocytes PMID: 27045862
    6. The expression of betatrophin is upregulated in the liver, white adipose tissue (WAT) and brown adipose tissue in obese hyperinsulinemic type 2 diabetes but decreased in WAT in hypoinsulinemic type 1 diabetes, suggesting its positive correlation with body weight and plasma insulin but not blood glucose. PMID: 27097546
    7. This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 and Angptl4 at different nutritional statuses. PMID: 26687026
    8. ANGPTL8 is a stress-response protein that down-regulates expression of ATGL. PMID: 26569053
    9. no substantial change in beta cell replication, mass or glucose homeostasis was observed following ANGPTL8 overexpression PMID: 25917759
    10. A monoclonal antibody against Angptl8, a feeding-induced hepatokine, lowers serum triglyceride levels when injected into mice. Angptl8 inhibits the activity of lipoprotein lipase in cardiac and skeletal muscle, but not in white adipose tissue. Therefore, Angptl8 acts, at least in part, in an endocrine manner, and its inhibition has therapeutical potential in treating hypertriglyceridemia. PMID: 26687026
    11. ANGPTL8 is not required for beta cell function or the compensatory beta cell growth response to insulin resistance, overexpression of ANGPTL8 does not increase beta cell area nor improve glycemic control, and ANGPTL8 regulates plasma triglyceride levels. PMID: 25417115
    12. Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. PMID: 24043787
    13. These results suggest Lipasin and some ANGPTLs play distinct physiological roles in mediating thermogenesis and energy homeostasis. PMID: 23261442
    14. Lipasin is a novel but atypical member of the angiopoietin-like protein family. PMID: 23261442
    15. Lipasin is thus a novel nutritionally-regulated liver-enriched factor that plays a role in lipid metabolism. PMID: 22809513
    16. RIFL is an important new regulator of lipid metabolism. PMID: 22569073

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    ANGPTL8 family
  • 組織特異性:
    Expressed in liver and fat. Enriched in white and brown adipose tissues.
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 久欠精品国国产99国产精2021| 国产精品成人无码久久久| 国产成人福利美女观看视频| 国产精品国产对白熟妇| 中文字幕aⅴ在线视频| 精品国产一区二区三区av性色| 亚洲人成网站观看在线播放| 影音先锋人妻每日资源站| 伊人久久大香线蕉影院| 无套内谢孕妇毛片免费看| 无码人妻久久一区二区三区| 免费无码观看的av在线播放| 国产三级精品三级在线专区| 韩国日本三级在线观看| 伊人久久五月丁香综合中文亚洲| 十八禁无码精品a∨在线观看| 久久天天躁狠狠躁夜夜2019| 国产亚洲精品久久久久久久| 欧洲-级毛片内射| 日本亚洲国产一区二区三区| 麻豆国产av尤物网站尤物| 国产黄大片在线观看画质优化| 国产成人精品.视频| 4hu四虎永久在线影院| 国产在线视频一区二区三区| 精品国产av色一区二区深夜久久| 午夜男女无遮挡拍拍视频| 亚洲一区二区三区自拍天堂| 亚洲精品成人区在线观看| 国产成人无码免费视频在线 | 欧美黑吊大战白妞| 午夜天堂精品久久久久| 妺妺跟我一起洗澡没忍住| 国产片av国语在线观麻豆| 国内精品视频一区二区三区| 色偷一区国产精品| 国内一区二区三区香蕉aⅴ| 亚洲中文字幕无码日韩精品| 久久国产精品-国产精品| 一本一本久久a久久综合精品蜜桃 国产精品人妻久久毛片高清无卡 成视频年人黄网站视频福利 | 国产午夜精品一区二区三区嫩草|