在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ATP5J Antibody

ATP5J Antibody

  • 中文名稱：
    ATP5J兔多克隆抗體
  • 貨號：
    CSB-PA002369ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA002369ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA002369ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ATP5J Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ATP synthase; H+ transporting; mitochondrial F0 complex; subunit F6 antibody; ATP synthase-coupling factor 6; mitochondrial antibody; ATP synthase-coupling factor 6; mitochondrial antibody; ATP5 antibody; ATP5A antibody; ATP5J antibody; ATP5J_HUMAN antibody; ATPase subunit F6 antibody; ATPM antibody; CF6 antibody; F6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ATP synthase-coupling factor 6, mitochondrial protein (1-108AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
  • 基因功能參考文獻：
    1. AKT2 and XIST expression was identified as a potential biomarker participating in the effect of ATP5J in colorectal cancer PMID: 29484395
    2. CF6-induced increase in apoptotic cells was blocked by immature or mature IF1, being accompanied by protein kinase B (PKB) phosphorylation. IF1 antagonizes the pro-apoptotic action of CF6 by relief of intracellular acidification and resultant phosphorylation of PKB. PMID: 26659871
    3. Over-expression of the ATP5J gene correlates with cell migration and 5-fluorouracil sensitivity in colorectal cancer. PMID: 24124598
    4. CF6 plays a crucial role in the development of insulin resistance and hypertension PMID: 22038518
    5. The phenotypic range of retinal, peripheral and central nervous system disease expression is characterized in a single family with NARP syndrome from the ATPase 6 m.8993T>C mtDNA point mutation. PMID: 20953793
    6. coupling factor 6 induces the development of systolic dysfunction and upregulation of nicotinamide adenine dinucleotide phosphate oxidase in the heart under the high-salt diet PMID: 20811295
    7. CF6 is a novel risk factor for ischemic heart disease in end-stage renal disease. Synergism of this peptide and asymmetric dimethylarginine might contribute to its occurrence presumably by inhibition of prostacyclin and nitric oxide production. PMID: 14633154
    8. Mutation analysis revealed the T9176C mutation in the mtATPase 6 gene (OMIM 516060) and the mutation load was above 90% in the patients with Leigh syndrome. PMID: 15709156
    9. Plasma CF6 elevated in patients with acute myocardial infarction. At 3 days, plasma CF6 correlated positively with plasma creatinine kinase peak value and correlated negatively with left ventricular ejection fraction. PMID: 15785006
    10. T8993G allele causes severe extrapyramidal dysfunction and Leigh disease but there is no correlation between the degree of enzyme deficiency and the severity of the phenotype. PMID: 16532470
    11. Increased CF6 may be responsible in part for decreased prostacyclin observed in coronary heart disease, in particular after PTCA and stent therapy. Potential risk factor for coronary heart disease. PMID: 17456993
    12. in vascular endothelial cells both CF6 (coupling factor 6) and Angiotensin II downregulate PECAM-1 (platelet/endothelial cell adhesion molecule) expression via activation of c-Src kinase PMID: 18243211
    13. Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells. PMID: 19106112

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion. Mitochondrion inner membrane.
  • 蛋白家族：
    Eukaryotic ATPase subunit F6 family
  • 數據庫鏈接：

    HGNC: 847

    OMIM: 603152

    KEGG: hsa:522

    STRING: 9606.ENSP00000389649

    UniGene: Hs.246310



主站蜘蛛池模板： 成人无码α片在线观看不卡| 亚洲国产成人乱码| 免费观看又色又爽又黄的崩锅| 特级a欧美做爰片三人交| 久久99日韩国产精品久久99| 免费无码肉片在线观看| 无码毛片视频一区二区本码| 东京热无码av一区二区| 亚洲中文字幕久久无码精品| 欧美video性欧美熟妇| 亚洲国产精品一区二区制服| 国产99久久精品一区二区| 精品深夜av无码一区二区| 国产精品 无码专区| 玩弄少妇的肉体k8经典| 国产亚洲色欲色一色www| 久久久亚洲一区二区三区| 久久人人爽人人爽人人片亞洲 | 久久精品国产只有精品96| 国产乱理伦片在线观看| 国产成人无码区免费内射一片色欲| 亚洲国产精品一区二区第四页 | 18禁无遮挡羞羞啪啪免费网站| 黑色丝袜无码中中文字幕| 性一交一乱一伦一色一情孩交| 久久伊人五月丁香狠狠色| 国产亚洲中文日韩欧美综合网| 亚洲va久久久噜噜噜久久无码| 亚洲狠狠婷婷综合久久久久图片| 色婷婷av久久久久久久| 国产高潮抽搐喷水高清| 国产美女精品中文网蜜芽宝贝| 最新高清无码专区| 人妻丰满熟妇无码区免费| 国产高清无套内谢| 伊人蕉久中文字幕无码专区| 人人澡人摸人人添| 国内丰满熟女出轨videos| 国产又粗又猛又黄又爽无遮挡 | 未满十八18禁止午夜免费网站 | 18禁黄久久久aaa片|