在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ATP12A Antibody

ATP12A Antibody

  • 中文名稱：
    ATP12A兔多克隆抗體
  • 貨號：
    CSB-PA004747
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of rat stomach cells using ATP1AL1 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ATP12A antibody; ATP1AL1Potassium-transporting ATPase alpha chain 2 antibody; EC 7.2.2.19 antibody; Non-gastric H(+)/K(+) ATPase subunit alpha antibody; Proton pump antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ATP1AL1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment. Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon. In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance.
  • 基因功能參考文獻：
    1. ATP12A knockdown or inhibition prevented the IL-13 dependent increase in airway surface liquid (ASL) viscosity but did not alter the ASL pH PMID: 29391451
    2. expressing human ATP12A in cystic fibrosis mouse airways acidified airway surface liquid, impaired defenses, and increased airway bacteria. PMID: 26823428
    3. Genetic association studies show that carriers of ATP12A rs10507337 C allele or CCTTC haplotype had better pattern of myocardial relaxation as compared to non-carriers. PMID: 25366262
    4. No significantly different expression levels could be detected in the various disease states compared to normal tissue. PMID: 22179016
    5. The presence of nongastric H-K-ATPase in rodent prostate apical membranes may indicate its involvement in potassium concentration regulation in secretions of these glands. PMID: 11880279
    6. Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1. PMID: 12110518
    7. Expressed in distal part of human colon and rectum, but also in proximal part of colon. Overexpressed in human colorectal adenocarcinomas adenocarcinomas. Astonishing levels of mRNA overexpression in carcinoma. PMID: 12230809
    8. Carboxy-terminus of HKalpha(2) facilitates proper folding of tHKalpha(2)/beta(1) complex allowing translocation of heterodimer to plasma membrane where potassium uptake occurs. Otherwise, alpha/beta complex is destined for degradation. PMID: 15086469
    9. non-gastric H(+)/K(+)ATPase is present in the microvillous plasma membrane of the transporting epithelia of the human placenta PMID: 15135233
    10. Inhibition of the ATP1AL1 isoenzyme of sodium potassium exchanging ATPase by 8-coumestrol is reported. PMID: 19487957
    11. Use of fold recognition methods enables a prediction that the C-terminal domain of the beta subunits of Na,K-ATPase and H,K-ATPase has an immunoglobulin-like fold, which resembles cell adhesion molecules. PMID: 19694409

    顯示更多

    收起更多

  • 亞細胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily
  • 組織特異性：
    Expressed in airway epithelial cells (at protein level). Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).
  • 數據庫鏈接：

    HGNC: 13816

    OMIM: 182360

    KEGG: hsa:479

    STRING: 9606.ENSP00000218548

    UniGene: Hs.147111



主站蜘蛛池模板： 成年女人免费视频播放体验区 | 特黄特色的大片观看免费视频| 久久国产美女精品久久| 久久激情综合狠狠爱五月| 三级全黄的视频在线观看| 久久久久波多野结衣高潮| 精品乱码久久久久久中文字幕| 越猛烈欧美xx00动态图| 又大又粗又长的高潮视频| 欧美成a人片在线观看久| 中文字幕精品无码一区二区三区| 日日躁夜夜躁狠狠躁| 午夜无码性爽快影院6080| 免费观看日本污污ww网站| 成年美女黄网站色大免费全看| 欧洲熟妇色xxxx欧美老妇| 韩国午夜福利片在线观看| 亚洲卡一卡二卡三新区乱码| 97人妻熟女成人免费视频色戒| 国产精品99精品无码视亚| 狠狠色婷婷久久综合频道日韩| 欧美性色黄大片www喷水| 好爽太紧了舒服视频| 一个添下面两个吃奶把腿扒开 | 人人妻人人藻人人爽欧美一区| 亚洲欧美综合一区二区三区| 精品无码成人久久久久久| 亚洲日韩乱码中文无码蜜桃臀| 无码av中文字幕久久专区| 欧美一道本一区二区三区| 欧美日产国产精品日产| 亚洲成a人片在线观看无码专区| 国产人妻人伦精品1国产| 久久精品成人欧美大片| 国产精品免费久久久久电影| 好吊视频一区二区三区| 永久免费观看黄网视频| 800av凹凸视频在线观看| 久久国产精品二国产精品| 18禁黄无遮挡网站免费| 久久毛片免费看一区二区三区|