在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ATIC Antibody

  • 中文名稱:
    ATIC兔多克隆抗體
  • 貨號:
    CSB-PA002299LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA002299LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA002299LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA002299LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA002299LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ATIC Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ATIC
  • 別名:
    AICAR formyltransferase/IMP cyclohydrolase antibody; 5 aminoimidazole 4 carboxamide 1 beta D ribonucleotide transformylase/inosinicase antibody; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase antibody; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase antibody; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase antibody; AICAR antibody; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme antibody; AICAR transformylase antibody; AICARFT antibody; AICARFT/IMPCHASE antibody; ATIC antibody; Bifunctional purine biosynthesis protein PURH antibody; epididymis secretory sperm binding protein Li 70p antibody; FLJ93545 antibody; HEL-S-70p antibody; IMP cyclohydrolase antibody; IMP synthase antibody; IMP synthetase antibody; IMPCHASE antibody; Inosinicase antibody; OK/SW-cl.86 antibody; Phosphoribosylaminoimidazolecarboxamide formyltransferase antibody; Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase antibody; PUR9_HUMAN antibody; PURH antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Bifunctional purine biosynthesis protein PURH protein (301-592AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,ATIC Antibody (CSB-PA002299LA01HU),的標記方式是Non-conjugated。對于ATIC Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA002299LB01HU ATIC Antibody, HRP conjugated ELISA
    FITC CSB-PA002299LC01HU ATIC Antibody, FITC conjugated
    Biotin CSB-PA002299LD01HU ATIC Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
  • 基因功能參考文獻:
    1. ATIC acts as an oncogenic gene that promotes survival, proliferation and migration by targeting AMPK-mTOR-S6 K1 signaling PMID: 29246230
    2. The AICARFT site is capable of independently binding both nucleotide and folate substrates with high affinity however no evidence for positive cooperativity in binding could be detected using the model ligands employed in this study. PMID: 29042184
    3. Pediatric Osteosarcoma patients with ATIC 347C>G exhibited a good histologic response to chemotherapy PMID: 28267080
    4. The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of methotrexate in Caucasian rheumatoid arthritis patients. PMID: 27379764
    5. ATIC 347C>G gene polymorphism may be associated with the development of MTX induced gastrointestinal adverse events. PMID: 26799664
    6. genotyping of ATIC rs2372536 and ITPA rs1127354 variants or measuring ITPA activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis. PMID: 25240429
    7. This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma PMID: 25823786
    8. PTPLAD1 and AMPK are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC later accumulates in the Golgi/endosome fraction. PMID: 25687571
    9. Single nucleotide polymorphisms in ATIC gene is associated with acute graft-versus-host disease. PMID: 25425682
    10. Our data show that ATIC is in complex with insulin receptor (IR)and siRNA-mediated partial knockdown of ATIC in HEK293 cells, decreases IR tyrosine phosphorylation and regulates IR endocytosis. Insulin stimulation and ATIC knockdown readily increase level of AMPK-Thr172 phosphorylation in IR complexes.ATIC depletion delayed insulin response of Glut2 translocation in HEK293 cells and decreased AKT-Ser473 phosphorylation. PMID: 25687571
    11. MTHFR, DHFR and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX monotherapy. PMID: 25084201
    12. study suggests that MTHFR C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX treatment and, therefore, assist clinicians in personalizing RA treatment PMID: 24967362
    13. Results proved in cultured skin fibroblasts from patients with AICA-ribosiduria that various mutations of ATIC destabilize to various degrees purinosome assembly. PMID: 22180458
    14. The kinetic mechanism of the human bifunctional enzyme ATIC PMID: 11948179
    15. crystal structure of ATIC PMID: 14966129
    16. Deficiency in AICAR transformylase is associated with severe neurological defects and congenital blindness PMID: 15114530
    17. Polymorphisms of reduced folate carrier,aminoimidazole carboxamide ribonucleotide transformylase,and thymidylate synthase genes contribute to the therapeutic response in rheumatoid arthritis patients to methotrexate. PMID: 15457444
    18. AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases. PMID: 17617058

    顯示更多

    收起更多

  • 相關疾病:
    AICAR transformylase/IMP cyclohydrolase deficiency (AICAR)
  • 蛋白家族:
    PurH family
  • 組織特異性:
    Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas.
  • 數據庫鏈接:

    HGNC: 794

    OMIM: 601731

    KEGG: hsa:471

    STRING: 9606.ENSP00000236959

    UniGene: Hs.90280



主站蜘蛛池模板: 亚洲国产成人综合一区二区三区| 国产小呦泬泬99精品| 日本一卡二卡不卡视频查询| 开心五月综合亚洲| 国产国拍亚洲精品av| 无人区乱码区1卡2卡三卡网站| 成在线人永久免费视频播放| 亚洲国产精品18久久久久久| 少妇被爽到高潮在线观看| 欧美3p两根一起进高清视频 | 黑人猛挺进小莹的体内视频| 蜜臀av色欲a片无码一区| 少妇人妻偷人精品无码视频新浪| 国产午夜精品一区二区| 成人亚洲a片v一区二区三区蜜臀| 精品日产一卡二卡| 国产9 9在线 | 欧洲| 狠狠色噜噜狠狠狠狠777米奇| 国产第一页浮力影院入口| 国产女厕所盗摄老师厕所嘘嘘| 精品欧美一区二区三区久久久| 日本特黄特色特爽大片| 精品国产乱码久久久久久下载| 国产欧美亚洲日韩图片| 精品国产偷窥一区二区| 国产一区二区三区在线蜜桃| 国产成人年无码av片在线观看 | 国产精品无码素人福利| 亚洲性人人天天夜夜摸18禁止 | 国产免费永久精品无码| 吃奶摸下的激烈视频| 麻婆豆传媒一区二区三区| 无码爆乳护士让我爽| 热re99久久精品国产66热| 99久热re在线精品视频| 精品亚洲国产成人av在线小说| 娇妻玩4p被三个男人伺候电影| 女乱高潮久久久久久爽爽| 激情射精爽到偷偷c视频无码| 国模无码视频一区二区三区| 国内精品久久久久久久久齐齐|