在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ATIC Antibody

  • 中文名稱:
    ATIC兔多克隆抗體
  • 貨號:
    CSB-PA136284
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA136284(ATIC Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 231 cell, Primary antibody: CSB-PA136284(ATIC Antibody) at dilution 1/350 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    ATIC
  • 別名:
    AICAR formyltransferase/IMP cyclohydrolase antibody; 5 aminoimidazole 4 carboxamide 1 beta D ribonucleotide transformylase/inosinicase antibody; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase antibody; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase antibody; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase antibody; AICAR antibody; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme antibody; AICAR transformylase antibody; AICARFT antibody; AICARFT/IMPCHASE antibody; ATIC antibody; Bifunctional purine biosynthesis protein PURH antibody; epididymis secretory sperm binding protein Li 70p antibody; FLJ93545 antibody; HEL-S-70p antibody; IMP cyclohydrolase antibody; IMP synthase antibody; IMP synthetase antibody; IMPCHASE antibody; Inosinicase antibody; OK/SW-cl.86 antibody; Phosphoribosylaminoimidazolecarboxamide formyltransferase antibody; Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase antibody; PUR9_HUMAN antibody; PURH antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human ATIC
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
  • 基因功能參考文獻:
    1. ATIC acts as an oncogenic gene that promotes survival, proliferation and migration by targeting AMPK-mTOR-S6 K1 signaling PMID: 29246230
    2. The AICARFT site is capable of independently binding both nucleotide and folate substrates with high affinity however no evidence for positive cooperativity in binding could be detected using the model ligands employed in this study. PMID: 29042184
    3. Pediatric Osteosarcoma patients with ATIC 347C>G exhibited a good histologic response to chemotherapy PMID: 28267080
    4. The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of methotrexate in Caucasian rheumatoid arthritis patients. PMID: 27379764
    5. ATIC 347C>G gene polymorphism may be associated with the development of MTX induced gastrointestinal adverse events. PMID: 26799664
    6. genotyping of ATIC rs2372536 and ITPA rs1127354 variants or measuring ITPA activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis. PMID: 25240429
    7. This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma PMID: 25823786
    8. PTPLAD1 and AMPK are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC later accumulates in the Golgi/endosome fraction. PMID: 25687571
    9. Single nucleotide polymorphisms in ATIC gene is associated with acute graft-versus-host disease. PMID: 25425682
    10. Our data show that ATIC is in complex with insulin receptor (IR)and siRNA-mediated partial knockdown of ATIC in HEK293 cells, decreases IR tyrosine phosphorylation and regulates IR endocytosis. Insulin stimulation and ATIC knockdown readily increase level of AMPK-Thr172 phosphorylation in IR complexes.ATIC depletion delayed insulin response of Glut2 translocation in HEK293 cells and decreased AKT-Ser473 phosphorylation. PMID: 25687571
    11. MTHFR, DHFR and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX monotherapy. PMID: 25084201
    12. study suggests that MTHFR C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX treatment and, therefore, assist clinicians in personalizing RA treatment PMID: 24967362
    13. Results proved in cultured skin fibroblasts from patients with AICA-ribosiduria that various mutations of ATIC destabilize to various degrees purinosome assembly. PMID: 22180458
    14. The kinetic mechanism of the human bifunctional enzyme ATIC PMID: 11948179
    15. crystal structure of ATIC PMID: 14966129
    16. Deficiency in AICAR transformylase is associated with severe neurological defects and congenital blindness PMID: 15114530
    17. Polymorphisms of reduced folate carrier,aminoimidazole carboxamide ribonucleotide transformylase,and thymidylate synthase genes contribute to the therapeutic response in rheumatoid arthritis patients to methotrexate. PMID: 15457444
    18. AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases. PMID: 17617058

    顯示更多

    收起更多

  • 相關疾病:
    AICAR transformylase/IMP cyclohydrolase deficiency (AICAR)
  • 蛋白家族:
    PurH family
  • 組織特異性:
    Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 794

    OMIM: 601731

    KEGG: hsa:471

    STRING: 9606.ENSP00000236959

    UniGene: Hs.90280



主站蜘蛛池模板: 欧美va天堂在线电影| 国产乱子伦一区二区三区四区五区| 亚洲欧美不卡高清在线| 亚洲精品一区国产精品| 成人乱人乱一区二区三区| 国产精自产拍在线看中文| 无码熟熟妇丰满人妻porn| 韩国日本三级在线观看| 亚洲久悠悠色悠在线播放 | 亚洲狠狠色成人综合网| 无码人妻少妇久久中文字幕蜜桃| 无码av岛国片在线播放| 国产精品爽爽va吃奶在线观看| 色偷偷av亚洲男人的天堂| 国产剧情麻豆女教师在线观看| 亚洲 欧美 另类 综合 日韩| av色综合久久天堂av色综合| 国产人妻精品久久久久野外| 日韩人妻无码制服丝袜视频| 久久婷婷五月综合色d啪| 在线观看免费视频网站a站| 18禁黄网站禁片免费观看| 国产精品无码av无码| 成人啪精品视频网站午夜| 国产 国语对白 露脸| 丰满少妇弄高潮了www| 一本久久a久久免费精品不卡| av性色在线乱叫| 久久久久黑人强伦姧人妻| 久久精品国产福利一区二区| 国产啪精品视频网站免| 人人爽人人片人人片av| 西西444www无码大胆| 亚洲国产精品成人综合色| 日本熟人妻中文字幕在线| 豆国产96在线 | 亚洲| 蜜臀精品国产高清在线观看| 亚洲欧美日韩综合久久久久久| 99国产精品国产精品九九| 成人免费无遮挡在线播放| 成人国产精品秘片多多|