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  4. ATG4A Antibody

ATG4A Antibody

  • 中文名稱：
    ATG4A兔多克隆抗體
  • 貨號：
    CSB-PA845174EA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: ATG4A antibody at 2µg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 46, 39, 37, 43 kDa
      Observed band size: 46 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ATG4A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    AI627006 antibody; APG4 autophagy 4 homolog A antibody; Apg4a antibody; ATG4 autophagy related 4 homolog A (S. cerevisiae) antibody; ATG4 autophagy related 4 homolog A antibody; ATG4A antibody; ATG4A_HUMAN antibody; Atg4al antibody; AUT like 2 cysteine endopeptidase antibody; AUT-like 2 cysteine endopeptidase antibody; Autl2 antibody; Autophagin 2 antibody; Autophagin-2 antibody; Autophagy related 4A cysteine peptidase antibody; Autophagy related cysteine endopeptidase 2 antibody; Autophagy related protein 4 homolog A antibody; Autophagy-related cysteine endopeptidase 2 antibody; Autophagy-related protein 4 homolog A antibody; AV169859 antibody; Cysteine protease ATG4A antibody; hAPG4A antibody; MGC107179 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Cysteine protease ATG4A protein (1-214AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ATG4A Antibody (CSB-PA845174EA01HU)，的標記方式是Non-conjugated。對于ATG4A Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA845174EB01HU ATG4A Antibody, HRP conjugated ELISA
    FITC CSB-PA845174EC01HU ATG4A Antibody, FITC conjugated
    Biotin CSB-PA845174ED01HU ATG4A Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.
  • 基因功能參考文獻：
    1. An intron SNP rs807185 in ATG4A might be a protective factor for lung cancer. PMID: 26061994
    2. ATG4A promotes the metastasis of gastric cancer cells via the Notch signaling pathway, which is an autophagy-independent mechanism PMID: 27276686
    3. The structure and regulatory machinery of Atg4a [review] PMID: 28253956
    4. We conclude that miR-24-3p regulates autophagy by targeting ATG4A PMID: 25426560
    5. The autophagy regulator ATG4A was found to be essential for the maintenance of a sub-population with cancer stem cell properties and to regulate breast cancer cell tumourigenicity. PMID: 24229464
    6. The demonstration that expression of ATG4A in cells increased stem properties provided an indication of its biological function. Hypomethylation of ATG4A and HIST1H2BN in ovarian tumor-initiating cells predicts poor prognosis for ovarian cancer patients. PMID: 24256813
    7. no association between SNP rs807185 and the presence of granulomas in Crohn's disease PMID: 21122541
    8. statistical analysis of APG4A gene confirmed the characterisation of each protein-coding gene present in human genome Xq22.1 PMID: 21297227
    9. Atg4B possessed the broadest spectrum against all substrates, followed by Atg4A for ATG8 substrates PMID: 21177865
    10. HsApg4A cleaves the COOH terminus of GATE-16 PMID: 12473658
    11. The cysteine protease HsAtg4 is identified as a direct target for oxidation by hydrogen peroxide, and a cysteine residue located near the HsAtg4 catalytic site as critical for this regulation. PMID: 17347651

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C54 family
  • 數據庫鏈接：

    HGNC: 16489

    OMIM: 300663

    KEGG: hsa:115201

    STRING: 9606.ENSP00000361306

    UniGene: Hs.8763



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