在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ASNA1 Antibody

ASNA1 Antibody

  • 中文名稱：
    ASNA1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA002218ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA002218ESR1HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA002218ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ASNA1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ASNA1
  • 別名：
    ARSA 1 antibody; ARSA antibody; ArsA arsenite transporter ATP binding homolog 1 antibody; ArsA arsenite transporter; ATP binding; E. coli; homolog of; 1 antibody; ArsA arsenite transporter; ATP-binding; homolog 1 (bacterial) antibody; ARSA I antibody; ARSA-I antibody; ARSA1 antibody; ARSAI antibody; Arsenical pump driving ATPase antibody; Arsenical pump-driving ATPase antibody; Arsenical resistance ATPase antibody; Arsenite translocating ATPase antibody; Arsenite transporting ATPase antibody; Arsenite-stimulated ATPase antibody; ASNA 1 antibody; ASNA I antibody; ASNA-I antibody; ASNA_HUMAN antibody; ASNA1 antibody; Asna1 protein antibody; ASNAI antibody; ATPase ASNA1 antibody; GET3 antibody; Golgi to ER traffic 3 homolog antibody; hARSA-I antibody; hASNA-I antibody; MGC3821 antibody; Transmembrane domain recognition complex 40 kDa ATPase subunit antibody; Transmembrane domain recognition complex; 40kDa antibody; TRC40 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human ATPase ASNA1 protein (1-348AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling.
  • 基因功能參考文獻(xiàn)：
    1. The authors conclude that the TRC40 pathway is critical for hearing and propose that otoferlin is an essential substrate of this pathway in hair cells. PMID: 27458190
    2. Asna1/TRC40 is required at a late step of herpes simplex virus type 1 infection for efficient release of mature virions to the extracellular milieu. PMID: 27765046
    3. reveal unanticipated complexity in the mutual regulation of the TRC40 receptor subunits and raise the question as to the role of the excess CAML in the endoplasmic reticulum PMID: 27226539
    4. Emerin interacts with TRC40 in situ. PMID: 26675233
    5. The repertoire of VAPB interactors is more diverse than previously anticipated and link VAPB to the function of ATPase complexes such as p97/FAF1 and ASNA1/transmembrane-domain recognition complex. PMID: 24885147
    6. Proteins bind to TRC40 and can utilise this component for their delivery to the ER membrane. PMID: 22505607
    7. PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway. PMID: 23460677
    8. Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells. PMID: 23041287
    9. Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone. PMID: 21878631
    10. The coiled-coil domain of WRB is the binding site for TRC40/Asna1. PMID: 21444755
    11. Asna1 is required for efficient histocompatibility (HLA) class I downregulation mediated by viral protein BNLF2a. PMID: 21296983
    12. Asna1 can mediate membrane insertion of RAMP4 and Sec61beta without the participation of other cytosolic proteins by a mechanism that depends on the presence of ATP or ADP and a protease-sensitive receptor in the endoplasmic reticulum membrane. PMID: 20375064
    13. Human ASNA1 is highly expressed in pancreatic beta cells, but not in other pancreatic endocrine cell types, and regulates insulin secretion in cultured cells. PMID: 17289575
    14. TRC40/Asna-1 interacts posttranslationally with tail-anchored proteins in a transmembrane domain-dependent manner for delivery to a proteinaceous receptor at the endoplasmic reticulum membrane. PMID: 17382883
    15. the hydrophobicity of the TA region dictates whether a precursor is delivered to the ER via the Hsp40/Hsc70 or Asna-1/TRC40-dependent route. PMID: 18667436
    16. ASNA1 is a target to overcome platinum resistance in ovarian cancer PMID: 19724867

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.
  • 蛋白家族：
    ArsA ATPase family
  • 組織特異性：
    Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 752

    OMIM: 601913

    KEGG: hsa:439

    STRING: 9606.ENSP00000349887

    UniGene: Hs.465985



主站蜘蛛池模板： 日产精品99久久久久久| 亚洲国产精品日韩av不卡在线| 日日噜噜夜夜狠狠久久蜜桃| 久久无码人妻国产一区二区| 丰满的少妇hd高清中文字幕| 少妇高潮av久久久久久| 老司机午夜福利视频| 欧美丰腴丰满大屁股熟妇| 一本久道久久综合久久爱| 在线a亚洲v天堂网2018| 欧美一区二区三区成人片在线| 精品国内自产拍在线观看视频| 亚洲曰本av在线天堂| 亚洲免费视频免在线观看| 久久婷婷五月综合97色一本一本| 婷婷综合久久中文字幕蜜桃三电影| 中文字幕av无码不卡免费| 国产成_人_综合_亚洲_国产| 国产成a人亚洲精品无码久久网| 亚洲中文字幕婷婷在线| 九九热久久只有精品2| 少妇无码一区二区三区免费| 十八18禁国产精品www| 在线观看一区二区三区国产免费| 超薄丝袜足j好爽在线观看| 国产精品久久久久久久久久红粉 | 天堂а√在线中文在线新版 | 动漫成人无码精品一区二区三区| 少妇群交换bd高清国语版| 色丁香婷婷综合久久| 国产色欲色欱www在线| 中国熟妇内谢69xxxxx| 国产丝袜视频一区二区三区| 成人乱人乱一区二区三区| 97se狠狠狠狠狼鲁亚洲综合色| 日本一区二区三区免费播放| 国产午夜精品无码| 新区乱码无人区二精东| 99久久精品国产免费| 学生妹亚洲一区二区| 国产亚洲福利在线视频|