在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ASNA1 Antibody

ASNA1 Antibody

  • 中文名稱：
    ASNA1兔多克隆抗體
  • 貨號：
    CSB-PA002218GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ASNA1
  • 別名：
    ARSA 1 antibody; ARSA antibody; ArsA arsenite transporter ATP binding homolog 1 antibody; ArsA arsenite transporter; ATP binding; E. coli; homolog of; 1 antibody; ArsA arsenite transporter; ATP-binding; homolog 1 (bacterial) antibody; ARSA I antibody; ARSA-I antibody; ARSA1 antibody; ARSAI antibody; Arsenical pump driving ATPase antibody; Arsenical pump-driving ATPase antibody; Arsenical resistance ATPase antibody; Arsenite translocating ATPase antibody; Arsenite transporting ATPase antibody; Arsenite-stimulated ATPase antibody; ASNA 1 antibody; ASNA I antibody; ASNA-I antibody; ASNA_HUMAN antibody; ASNA1 antibody; Asna1 protein antibody; ASNAI antibody; ATPase ASNA1 antibody; GET3 antibody; Golgi to ER traffic 3 homolog antibody; hARSA-I antibody; hASNA-I antibody; MGC3821 antibody; Transmembrane domain recognition complex 40 kDa ATPase subunit antibody; Transmembrane domain recognition complex; 40kDa antibody; TRC40 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ASNA1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling.
  • 基因功能參考文獻：
    1. The authors conclude that the TRC40 pathway is critical for hearing and propose that otoferlin is an essential substrate of this pathway in hair cells. PMID: 27458190
    2. Asna1/TRC40 is required at a late step of herpes simplex virus type 1 infection for efficient release of mature virions to the extracellular milieu. PMID: 27765046
    3. reveal unanticipated complexity in the mutual regulation of the TRC40 receptor subunits and raise the question as to the role of the excess CAML in the endoplasmic reticulum PMID: 27226539
    4. Emerin interacts with TRC40 in situ. PMID: 26675233
    5. The repertoire of VAPB interactors is more diverse than previously anticipated and link VAPB to the function of ATPase complexes such as p97/FAF1 and ASNA1/transmembrane-domain recognition complex. PMID: 24885147
    6. Proteins bind to TRC40 and can utilise this component for their delivery to the ER membrane. PMID: 22505607
    7. PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway. PMID: 23460677
    8. Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells. PMID: 23041287
    9. Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone. PMID: 21878631
    10. The coiled-coil domain of WRB is the binding site for TRC40/Asna1. PMID: 21444755
    11. Asna1 is required for efficient histocompatibility (HLA) class I downregulation mediated by viral protein BNLF2a. PMID: 21296983
    12. Asna1 can mediate membrane insertion of RAMP4 and Sec61beta without the participation of other cytosolic proteins by a mechanism that depends on the presence of ATP or ADP and a protease-sensitive receptor in the endoplasmic reticulum membrane. PMID: 20375064
    13. Human ASNA1 is highly expressed in pancreatic beta cells, but not in other pancreatic endocrine cell types, and regulates insulin secretion in cultured cells. PMID: 17289575
    14. TRC40/Asna-1 interacts posttranslationally with tail-anchored proteins in a transmembrane domain-dependent manner for delivery to a proteinaceous receptor at the endoplasmic reticulum membrane. PMID: 17382883
    15. the hydrophobicity of the TA region dictates whether a precursor is delivered to the ER via the Hsp40/Hsc70 or Asna-1/TRC40-dependent route. PMID: 18667436
    16. ASNA1 is a target to overcome platinum resistance in ovarian cancer PMID: 19724867

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.
  • 蛋白家族：
    ArsA ATPase family
  • 組織特異性：
    Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 752

    OMIM: 601913

    KEGG: hsa:439

    STRING: 9606.ENSP00000349887

    UniGene: Hs.465985



主站蜘蛛池模板： 精品国产午夜福利在线观看| 蜜桃网站入口在线进入| 国产成人无码性教育视频 | 亚洲久久中文字幕www网站| 欧美大片18禁aaa免费视频| 日本护士xxxxhd少妇| 国产精品乱码高清在线观看| 色爱无码av综合区| 亚洲欧美日本国产专区一区| 人人妻碰人人免费| 免费观看性欧美大片无片| 久久人妻少妇嫩草av无码专区 | 国产aⅴ视频免费观看| 亚洲国产精品无码中文字| 男ji大巴进入女人的直播| 成熟女人毛片www免费版在线| 99er国产这里只有精品视频免费| 亚洲色欲色欲77777小说网站| 人妻少妇精品一区二区三区| 亚洲国产成人一区二区精品区| 日本狂喷奶水在线播放212| 国产欧美丝袜在线二区| 麻豆果冻传媒2021精品传媒一区| 推油少妇久久99久久99久久| 中文字幕婷婷日韩欧美亚洲| 99大香伊乱码一区二区| 丰满的少妇愉情hd高清果冻传媒 | 久久人妻无码中文字幕| a毛片免费全部播放自慰| 日日摸日日碰夜夜爽av| 女人爽得直叫免费视频| 国产精品无码综合区| 国产360激情盗摄全集| 精品无码av无码免费专区| 人妻大战黑人白浆狂泄| 亚洲国产精品一区二区第四页 | 男人猛躁进女人免费播放 | 色爽黄1000部免费软件下载| 亚洲人成无码网站在线观看| 蜜桃网站入口可看18禁| 五月丁香啪啪|