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ASCC3 Antibody

  • 中文名稱：
    ASCC3兔多克隆抗體
  • 貨號：
    CSB-PA002198ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA002198ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA002198ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA002198ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ASCC3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ASCC3
  • 別名：
    Activating signal cointegrator 1 complex subunit 3 antibody; ASC-1 complex subunit p200 antibody; ASC-1 complex subunit p200-KD subunit antibody; ASC1p200 antibody; ascc3 antibody; ATP binding 1 antibody; B630009I04Rik antibody; dJ121G13.4 antibody; DJ467N11.1 antibody; HELC1_HUMAN antibody; HELIC1 antibody; Helicase antibody; helicase; ATP binding 1 antibody; p200 antibody; RNA helicase family antibody; RNAH antibody; RP1-121G13.4 antibody; Trip4 complex subunit p200 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Activating signal cointegrator 1 complex subunit 3 protein (1-111AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.
  • 基因功能參考文獻：
    1. UV exposure results in spatial restriction of transcription and slower elongation, with the result that only the promoter-proximal 20-25 kb are efficiently transcribed; these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3. PMID: 28215706
    2. ASCC3 Gene Polymorphism was associated with Chronic Hepatitis B. PMID: 26536629
    3. Silencing of ASCC3 resulted in upregulation of multiple antiviral interferon-stimulated genes, which correlated with inhibition of infection of several positive-strand RNA viruses. PMID: 23781071
    4. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. PMID: 22055184
  • 亞細胞定位：
    Nucleus. Nucleus speckle. Cytoplasm, cytosol.
  • 蛋白家族：
    Helicase family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 18697

    OMIM: 614217

    KEGG: hsa:10973

    STRING: 9606.ENSP00000358159

    UniGene: Hs.486031



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