在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ARSB Antibody

  • 中文名稱:
    ARSB兔多克隆抗體
  • 貨號:
    CSB-PA002142GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    ARSB
  • 別名:
    Arsb antibody; ARSB_HUMAN antibody; Arylsulfatase B antibody; ArylsulfataseB antibody; ASB antibody; G4S antibody; MPS6 antibody; N acetylgalactosamine 4 sulfatase antibody; N-acetylgalactosamine-4-sulfatase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ARSB
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels.
  • 基因功能參考文獻:
    1. Findings indicate that lower arylsulfatase B (ARSB) is associated with prostate cancer recurrence. PMID: 29081414
    2. Of the 20 patients included in the study, molecular genetic analysis was performed on 17 patients... molecular analysis results of four patients who was excluded from the overall study (three of which were another adult male siblings who did not receive ERT and one patient whose ERT duration was shorter than 6 months) were were included in determination of allele frequency of ARSB. PMID: 28884960
    3. Three novel mutations in ARSB were detected, expanding the mutational spectrum of ARSB causing MPS VI. A compound heterozygous for the c.464G>A (p.C155Y) and c.1163G>C (p.R388T) mutations, a 13.8-kb deletion encompassing exons 2 and 3, mutation c.479G>A (p.R160Q), and novel c.464G>A (p.C155Y) mutation. PMID: 27797586
    4. Mutation analysis of 19 Indian mucopolysaccharidosis VI patients revealed the presence of a total of 15 different mutations of which twelve were novel. PMID: 27826022
    5. Nine novel mutations of ARSB were identified in MPS VI cases from India in the present study. The study also provides some insights into the genotype-phenotype association in MPS VI PMID: 26609033
    6. Silencing Wnt9A increased the expression of CHST11 in the colonic epithelial cells, and chromatin immunoprecipitation assay demonstrated enhancing effects of Wnt9A siRNA and exogenous BMP4 on the CHST11 promoter PMID: 25511584
    7. Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects. PMID: 24240681
    8. Mutation analysis of the ARSB gene revealed seven missense and three frameshift mutations of which eight were novel. PMID: 24677745
    9. These studies reveal how carrageenan exposure can lead to transcriptional events in colonic epithelial cells through decline in arylsulfatase B activity, with subsequent impact on C4S, galectin-3, Sp1, and Wnt9A PMID: 24778176
    10. novel homozygous missense mutation, c.278 C>T, p.P93L, associated with mucopolysaccharidosis type VI PMID: 23855929
    11. ARSB activity was significantly higher in the normal tissues. PMID: 23835622
    12. PTC124 but not gentamicin, increases the level of ARSB activity. PMID: 22971959
    13. results indicate that mammalian ARSB improves functional recovery after CNS injury. PMID: 23520469
    14. Arylsulfatase B activity was significantly less in the polymorphonuclear leukocytes and mononuclear cells from the cystic fibrosis patients than controls. PMID: 22550062
    15. Sequencing analysis revealed a novel homozygous missense mutation in the ARSB gene at c.1457A PMID: 23023219
    16. investigation of substrate specificity of arylsulfatase B in colonic epithelial cells; competitive binding of complex polysaccharides/glycosaminoglycans with arylsulfatase B can affect generation of reactive oxygen species and inflammatory response PMID: 22079206
    17. Hypoxia reduces arylsulfatase B activity and silencing arylsulfatase B replicates and mediates the effects of hypoxia. PMID: 22428001
    18. 13 mucopolysaccharidosis type VI patients were found to be homozygous for the previously undescribed H178L ARSB mutation PMID: 21996138
    19. Altered ARSB immunostaining and reduced activity may be useful indicators of malignant transformation in human colonic tissue. PMID: 21378286
    20. Mucopolysaccharidosis type VI: Structural and clinical implications of mutations in N-acetylgalactosamine-4-sulfatase PMID: 11668612
    21. Seven novel mutation were identified in ARSB in mucopolysaccharidosis type VI patients undergoing a Clinical trial of enzyme replacement therapy, 3 of these mutations resulted in truncated proteins. PMID: 14974081
    22. analysis of novel mutations on the arylsulphatase B gene in South American Mucopolysaccharidosis type VI patients PMID: 16435196
    23. Decreased arylsulfatase B activity is associated with cystic fibrosis PMID: 17324393
    24. The identification of many novel mutations unique to individuals/their families highlighted the genetic heterogeneity of the mucopolysaccharidosis VI disorder. PMID: 17458871
    25. Novel mutations in arylsulfatase B is associated with mucopolysaccharidosis VI PMID: 17643332
    26. modification of expression of the lysosomal sulfatases ASB and GALNS regulates the content of CSs. PMID: 18285341
    27. Reduced activity of arylsulfatase B enzymatic activity in children with cystic fibrosis PMID: 18299243
    28. All the ARSB mutations studied had a significant effect on enzyme activity, protein processing and/or mRNA stability. PMID: 18406185
    29. arylsulfatase B gene mutation profile in Taiwanese MPS VI patients may be different from MPS VI patients from other countries[mucopolysaccharidosis type VI ] PMID: 18486607
    30. IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate PMID: 19346317

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Mucopolysaccharidosis 6 (MPS6); Multiple sulfatase deficiency (MSD)
  • 亞細胞定位:
    Lysosome. Cell surface.
  • 蛋白家族:
    Sulfatase family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 714

    OMIM: 253200

    KEGG: hsa:411

    STRING: 9606.ENSP00000264914

    UniGene: Hs.149103



主站蜘蛛池模板: 欧美性黑人极品hd另类| 一个人看的www视频免费观看| 日本肥老妇色xxxxx日本老妇| 性无码专区无码片| 99久久亚洲综合精品成人| 少妇被多人c夜夜爽爽| 最近中文字幕在线中文视频| 精产国品一二三产区蘑菇视频| 动漫成人无码精品一区二区三区| 99国精品午夜福利视频不卡| 熟睡人妻被讨厌的公侵犯| 亚洲a∨国产av综合av| 亚洲成a人片在线观看天堂| 国产女女做受ⅹxx高潮 | 亚洲综合av永久无码精品一区二区| 中文字幕人妻被公上司喝醉在线| 中文字幕 欧美精品 第1页| 在教室伦流澡到高潮hgl视频| 久久99国产综合精品免费| 好了av在线第四综合网站| 无码免费中文字幕视频| 各种少妇正面bbw撒尿| 亚洲在线国产日韩欧美| 亚洲午夜成人精品无码app| 天堂中文在线最新版地址| 天天摸天天碰天天添| 国产精品成人永久在线| 欧美日韩视频在线第一区| 久久久久成人精品| 99久久久无码国产精品秋霞网| 国产无遮挡乱子伦免费精品| 人妻av无码专区| 婷婷久久综合九色综合88| 激情综合色五月六月婷婷| 国产精品自在拍首页视频| 亚洲色婷婷一区二区三区| 欧妇女乱妇女乱视频| 日韩少妇白浆无码系列| 久久国产精品_国产精品| 亚洲色偷偷偷综合网| 麻豆精品一卡二卡三卡|