在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ARSB Antibody

  • 中文名稱:
    ARSB兔多克隆抗體
  • 貨號:
    CSB-PA002142LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: ARSB antibody at 2µg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit lgG at 1/15000 dilution
      Predicted band size: 60, 46 kDa
      Observed band size: 40 kDa
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) ARSB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ARSB
  • 別名:
    Arsb antibody; ARSB_HUMAN antibody; Arylsulfatase B antibody; ArylsulfataseB antibody; ASB antibody; G4S antibody; MPS6 antibody; N acetylgalactosamine 4 sulfatase antibody; N-acetylgalactosamine-4-sulfatase antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Arylsulfatase B protein (37-533AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,ARSB Antibody (CSB-PA002142LA01HU),的標(biāo)記方式是Non-conjugated。對于ARSB Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA002142LB01HU ARSB Antibody, HRP conjugated ELISA
    FITC CSB-PA002142LC01HU ARSB Antibody, FITC conjugated
    Biotin CSB-PA002142LD01HU ARSB Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels.
  • 基因功能參考文獻(xiàn):
    1. Findings indicate that lower arylsulfatase B (ARSB) is associated with prostate cancer recurrence. PMID: 29081414
    2. Of the 20 patients included in the study, molecular genetic analysis was performed on 17 patients... molecular analysis results of four patients who was excluded from the overall study (three of which were another adult male siblings who did not receive ERT and one patient whose ERT duration was shorter than 6 months) were were included in determination of allele frequency of ARSB. PMID: 28884960
    3. Three novel mutations in ARSB were detected, expanding the mutational spectrum of ARSB causing MPS VI. A compound heterozygous for the c.464G>A (p.C155Y) and c.1163G>C (p.R388T) mutations, a 13.8-kb deletion encompassing exons 2 and 3, mutation c.479G>A (p.R160Q), and novel c.464G>A (p.C155Y) mutation. PMID: 27797586
    4. Mutation analysis of 19 Indian mucopolysaccharidosis VI patients revealed the presence of a total of 15 different mutations of which twelve were novel. PMID: 27826022
    5. Nine novel mutations of ARSB were identified in MPS VI cases from India in the present study. The study also provides some insights into the genotype-phenotype association in MPS VI PMID: 26609033
    6. Silencing Wnt9A increased the expression of CHST11 in the colonic epithelial cells, and chromatin immunoprecipitation assay demonstrated enhancing effects of Wnt9A siRNA and exogenous BMP4 on the CHST11 promoter PMID: 25511584
    7. Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects. PMID: 24240681
    8. Mutation analysis of the ARSB gene revealed seven missense and three frameshift mutations of which eight were novel. PMID: 24677745
    9. These studies reveal how carrageenan exposure can lead to transcriptional events in colonic epithelial cells through decline in arylsulfatase B activity, with subsequent impact on C4S, galectin-3, Sp1, and Wnt9A PMID: 24778176
    10. novel homozygous missense mutation, c.278 C>T, p.P93L, associated with mucopolysaccharidosis type VI PMID: 23855929
    11. ARSB activity was significantly higher in the normal tissues. PMID: 23835622
    12. PTC124 but not gentamicin, increases the level of ARSB activity. PMID: 22971959
    13. results indicate that mammalian ARSB improves functional recovery after CNS injury. PMID: 23520469
    14. Arylsulfatase B activity was significantly less in the polymorphonuclear leukocytes and mononuclear cells from the cystic fibrosis patients than controls. PMID: 22550062
    15. Sequencing analysis revealed a novel homozygous missense mutation in the ARSB gene at c.1457A PMID: 23023219
    16. investigation of substrate specificity of arylsulfatase B in colonic epithelial cells; competitive binding of complex polysaccharides/glycosaminoglycans with arylsulfatase B can affect generation of reactive oxygen species and inflammatory response PMID: 22079206
    17. Hypoxia reduces arylsulfatase B activity and silencing arylsulfatase B replicates and mediates the effects of hypoxia. PMID: 22428001
    18. 13 mucopolysaccharidosis type VI patients were found to be homozygous for the previously undescribed H178L ARSB mutation PMID: 21996138
    19. Altered ARSB immunostaining and reduced activity may be useful indicators of malignant transformation in human colonic tissue. PMID: 21378286
    20. Mucopolysaccharidosis type VI: Structural and clinical implications of mutations in N-acetylgalactosamine-4-sulfatase PMID: 11668612
    21. Seven novel mutation were identified in ARSB in mucopolysaccharidosis type VI patients undergoing a Clinical trial of enzyme replacement therapy, 3 of these mutations resulted in truncated proteins. PMID: 14974081
    22. analysis of novel mutations on the arylsulphatase B gene in South American Mucopolysaccharidosis type VI patients PMID: 16435196
    23. Decreased arylsulfatase B activity is associated with cystic fibrosis PMID: 17324393
    24. The identification of many novel mutations unique to individuals/their families highlighted the genetic heterogeneity of the mucopolysaccharidosis VI disorder. PMID: 17458871
    25. Novel mutations in arylsulfatase B is associated with mucopolysaccharidosis VI PMID: 17643332
    26. modification of expression of the lysosomal sulfatases ASB and GALNS regulates the content of CSs. PMID: 18285341
    27. Reduced activity of arylsulfatase B enzymatic activity in children with cystic fibrosis PMID: 18299243
    28. All the ARSB mutations studied had a significant effect on enzyme activity, protein processing and/or mRNA stability. PMID: 18406185
    29. arylsulfatase B gene mutation profile in Taiwanese MPS VI patients may be different from MPS VI patients from other countries[mucopolysaccharidosis type VI ] PMID: 18486607
    30. IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate PMID: 19346317

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Mucopolysaccharidosis 6 (MPS6); Multiple sulfatase deficiency (MSD)
  • 亞細(xì)胞定位:
    Lysosome. Cell surface.
  • 蛋白家族:
    Sulfatase family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 714

    OMIM: 253200

    KEGG: hsa:411

    STRING: 9606.ENSP00000264914

    UniGene: Hs.149103



主站蜘蛛池模板: 日韩亚洲国产激情一区浪潮av| 久久精品国产99精品国产亚洲性色 | 国产精品va无码二区| 亚洲国产成人精品无码区在线| 欧美人与性囗牲恔配| 亚洲精品www久久久久久 | 亚洲国产成人极品综合| 黄网站色视频免费国产| 国产成人剧情av麻豆果冻| 成人网站国产在线视频内射视频 | 亚洲毛片αv无线播放一区| 亚洲国产成人久久综合一区| 色情久久久av熟女人妻网站| 国产黄在线观看免费观看不卡| 日韩a人毛片精品无人区乱码| 涩欲国产一区二区三区四区 | 国产白丝精品爽爽久久蜜臀| av片亚洲国产男人的天堂| 在线 | 国产精品星空传媒丿| 无码av大香线蕉伊人久久| 亚洲国产精品一区第二页| 人妻天天爽夜夜爽精品视频| 亚洲综合无码一区二区痴汉| 2020国产精品午夜福利在线观看| 两口子交换真实刺激高潮| 精品国产一区二区三区四区五区| 亚洲亚洲熟妇色l图片20p| 私人家庭影院5777| 怡红院av亚洲一区二区三区h| 色国产精品一区在线观看| 天天做天天爱天天综合网2021| 一本到中文无码av在线精品| 2021国产成人精品久久| 农民人伦一区二区三区| 女人色极品影院| 久久精品囯产精品亚洲| 边喂奶边中出的人妻| 亚洲色欲综合一区二区三区| 国产精品高潮呻吟av久久4虎 | 中文字幕制服丝袜第57页| 久久超乳爆乳中文字幕|