在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ARPC1B Antibody

ARPC1B Antibody

  • 中文名稱：
    ARPC1B兔多克隆抗體
  • 貨號(hào)：
    CSB-PA002126LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA002126LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ARPC1B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Actin related protein 2/3 complex subunit 1B 41kDa antibody; Actin related protein 2/3 complex subunit 1B antibody; Actin-related protein 2/3 complex subunit 1B antibody; ARC1B_HUMAN antibody; ARC41 antibody; Arp2/3 complex 41 kDa subunit antibody; ARP2/3 protein complex subunit p41 antibody; Arpc1b antibody; p40 ARC antibody; p41 ARC antibody; p41-Arc antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Actin-related protein 2/3 complex subunit 1B protein (16-316AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，ARPC1B Antibody (CSB-PA002126LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于ARPC1B Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA002126LB01HU ARPC1B Antibody, HRP conjugated ELISA
    FITC CSB-PA002126LC01HU ARPC1B Antibody, FITC conjugated
    Biotin CSB-PA002126LD01HU ARPC1B Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
  • 基因功能參考文獻(xiàn)：
    1. A homozygous frameshift mutation in ARPC1B (p.Val91Trpfs*30) was identified in a child with microthrombocytopenia, eosinophilia and inflammatory disease. Platelet lysates contained no ARPC1B protein and reduced Arp2/3 complex. Missense ARPC1B mutations were identified in an unrelated patient with similar symptoms and ARPC1B deficiency. ARPC1B-deficient platelets are microthrombocytes with abnormal spreading behavior. PMID: 28368018
    2. A homozygous 2 bp deletion, n.c.G623DEL-TC (p.V208VfsX20), in Arp2/3 complex component ARPC1B that causes a frame shift resulting in premature termination was found in 2 brothers with hematopoietic and immunologic symptoms reminiscent of Wiskott-Aldrich syndrome. Wild-type ARPC1B but not mutant was able to rescue a deficiency in a zebrafish model. ARPC1B expression is restricted to hematopoietic cells. PMID: 29127144
    3. This study identified two low-frequency nonsynonymous variants at FKBPL (rs200847762, OR = 0.34, 95% CI = 0.20-0.57, P = 4.31 x 10-5) and ARPC1B (rs1045012, OR = 0.56, 95% CI = 0.43-0.74, P = 4.30 x 10-5) associated with breast cancer risk. PMID: 27479355
    4. low-expression of ARPC1B is significantly associated with LNM and advanced tumor staging whereas high expression of Cav-1 can be a prognostic indicator for poor prognosis in OSCC patients. PMID: 26138391
    5. p41-Arc activates a senescence program in p53- and Rb-independent ways. PMID: 21628992
    6. Arpc1b is both a physiological activator and substrate of Aurora A kinase and these interactions help to maintain mitotic integrity in mammalian cells. PMID: 20603326
    7. INSIG1 and p41 Arp2/3 complex (p41-Arc)reduced expression might be involved in gastric cancer development or progression PMID: 12115587
    8. Phosphorylation of p41-ARC by p21-activated kinase 1. PMID: 14749719
    9. From the analysis of the different radio-sensitivity cancer cell lines, the Arpc1b gene was selected as a prediction marker gene for sensitivity of CMM to radiotherapy. PMID: 16723437

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton. Nucleus.
  • 蛋白家族：
    WD repeat ARPC1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 704

    OMIM: 604223

    KEGG: hsa:10095

    STRING: 9606.ENSP00000252725

    UniGene: Hs.489284



主站蜘蛛池模板： 狂野欧美激情性xxxx按摩| 俺去俺来也www色官网| 天堂在线资源中文在线8| 国内精品久久毛片一区二区| 伊人久久大香线焦av色| 四虎国产精品成人免费久久| 亚洲熟悉妇女xxx妇女av| 99久久99久久精品免费观看 | 国产性猛交╳xxx乱大交| 人妻去按摩店被黑人按中出| 2021精品亚洲中文字幕| 激情综合亚洲色婷婷五月| 色拍拍在线精品视频| 国产呻吟久久久久久久92| 尤物蜜芽国产成人精品区| 亚洲国产成人久久综合下载| 中文字幕日韩人妻在线视频| 日韩人妻无码精品二专区| 国产午夜亚洲精品久久| 人妻丰满熟妇av无码区不卡| 久久久久久久久蜜桃| 男女久久久国产一区二区三区| 精品国产免费一区二区三区香蕉| 成人午夜精品无码区久久| 亚洲中国精品精华液| 国产人成高清在线视频99最全资源 | 久久人妻无码中文字幕第一| 国产一区二区波多野结衣| 欧美大屁股熟妇bbbbbb| 2021久久最新国产精品| 国产专区一线二线三线码| a国产在线v的不卡视频| 国产免费无遮挡吸奶头视频 | 日本无翼乌邪恶大全彩h| 久久亚洲中文字幕无码| 大地资源中文在线观看官网第二页 | 神马午夜福利不卡片在线| 亚洲精品无码mⅴ在线观看| 亚洲国产一区二区三区| 久久不见久久见免费视频7 | 18禁无码永久免费无限制网站 |