在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ARPC1B Antibody, FITC conjugated

  • 中文名稱:
    ARPC1B兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA002126LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ARPC1B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Actin related protein 2/3 complex subunit 1B 41kDa antibody; Actin related protein 2/3 complex subunit 1B antibody; Actin-related protein 2/3 complex subunit 1B antibody; ARC1B_HUMAN antibody; ARC41 antibody; Arp2/3 complex 41 kDa subunit antibody; ARP2/3 protein complex subunit p41 antibody; Arpc1b antibody; p40 ARC antibody; p41 ARC antibody; p41-Arc antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Actin-related protein 2/3 complex subunit 1B protein (16-316AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
  • 基因功能參考文獻:
    1. A homozygous frameshift mutation in ARPC1B (p.Val91Trpfs*30) was identified in a child with microthrombocytopenia, eosinophilia and inflammatory disease. Platelet lysates contained no ARPC1B protein and reduced Arp2/3 complex. Missense ARPC1B mutations were identified in an unrelated patient with similar symptoms and ARPC1B deficiency. ARPC1B-deficient platelets are microthrombocytes with abnormal spreading behavior. PMID: 28368018
    2. A homozygous 2 bp deletion, n.c.G623DEL-TC (p.V208VfsX20), in Arp2/3 complex component ARPC1B that causes a frame shift resulting in premature termination was found in 2 brothers with hematopoietic and immunologic symptoms reminiscent of Wiskott-Aldrich syndrome. Wild-type ARPC1B but not mutant was able to rescue a deficiency in a zebrafish model. ARPC1B expression is restricted to hematopoietic cells. PMID: 29127144
    3. This study identified two low-frequency nonsynonymous variants at FKBPL (rs200847762, OR = 0.34, 95% CI = 0.20-0.57, P = 4.31 x 10-5) and ARPC1B (rs1045012, OR = 0.56, 95% CI = 0.43-0.74, P = 4.30 x 10-5) associated with breast cancer risk. PMID: 27479355
    4. low-expression of ARPC1B is significantly associated with LNM and advanced tumor staging whereas high expression of Cav-1 can be a prognostic indicator for poor prognosis in OSCC patients. PMID: 26138391
    5. p41-Arc activates a senescence program in p53- and Rb-independent ways. PMID: 21628992
    6. Arpc1b is both a physiological activator and substrate of Aurora A kinase and these interactions help to maintain mitotic integrity in mammalian cells. PMID: 20603326
    7. INSIG1 and p41 Arp2/3 complex (p41-Arc)reduced expression might be involved in gastric cancer development or progression PMID: 12115587
    8. Phosphorylation of p41-ARC by p21-activated kinase 1. PMID: 14749719
    9. From the analysis of the different radio-sensitivity cancer cell lines, the Arpc1b gene was selected as a prediction marker gene for sensitivity of CMM to radiotherapy. PMID: 16723437

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Nucleus.
  • 蛋白家族:
    WD repeat ARPC1 family
  • 數據庫鏈接:

    HGNC: 704

    OMIM: 604223

    KEGG: hsa:10095

    STRING: 9606.ENSP00000252725

    UniGene: Hs.489284



主站蜘蛛池模板: 日本久久综合久久综合| 免费久久99精品国产自在现线 | 任我橹这里只有精品 在线视频 | 久久精品动漫一区二区三区| 国产精品成人免费999| 国内精品乱码卡一卡2卡| 乱码国产丰满人妻www| 明星性猛交ⅹxxx乱大交| 黑巨人与欧美精品一区| 337p粉嫩日本欧洲亚福利| 久久精品www人人做人人爽| 无套中出极品少妇白浆| 97午夜理论片在线影院| 亚洲综合无码中文字幕第2页| 97人人超碰国产精品最新| 丰满少妇人妻无码专区 | 成人国产三级在线观看| 久久综合狠狠综合久久综| 成人午夜亚洲精品无码区| 3d动漫精品啪啪一区二区下载| 狼人大香伊蕉国产www亚洲| 国产成人av在线播放影院| 顶级少妇做爰视频在线观看| 最近中文字幕mv在线视频2018| 无码人妻丰满熟妇啪啪欧美 | 鲁丝片一区二区三区毛片| 午夜伦4480yy私人影院久久| 2019国产品在线视频| 精品欧洲av无码一区二区| 日韩av无码久久一区二区| 东京热加勒比视频一区 | 熟妇人妻中文字幕| 国产-第1页-浮力影院| 天天摸天天做天天爽天天弄| 欧美做受又硬又粗又大视频| 国产精品白丝喷水在线观看| 国产精品国产三级国av麻豆| 国内精品自线一区二区三区2021 | 亚洲欧美日韩另类精品一区| 国产成人精品123区免费视频| 国产成人综合亚洲色就色|