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  4. ARHGEF3 Antibody

ARHGEF3 Antibody

  • 中文名稱：
    ARHGEF3兔多克隆抗體
  • 貨號：
    CSB-PA878863ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA878863ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ARHGEF3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ARHGEF3
  • 別名：
    ARHGEF3 antibody; Rho guanine nucleotide exchange factor 3 antibody; Exchange factor found in platelets and leukemic and neuronal tissues antibody; XPLN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Rho guanine nucleotide exchange factor 3 protein (287-526AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
  • 基因功能參考文獻(xiàn)：
    1. This is the first study describing the involvement of XPLN in the regulation of the mTORC2-SPARC axis, and these findings may help uncover regulatory mechanisms mediated by XPLN in idiopathic pulmonary fibrosis PMID: 28315487
    2. Our findings suggest that increased expression of ARHGEF3 plays a critical oncogenic role in nasopharyngeal carcinoma pathogenesis PMID: 27028992
    3. Data suggest that modulation of ARHGEF3 gene expression in humans with a promoter-localized SNP plays a role in human megakaryocytes and human platelet function-a finding resulting from the biological follow-up of human genetic studies. Arhgef3 KO mice partially recapitulate the human phenotype. PMID: 28542600
    4. ARHGEF3 has a crucial role in myeloid differentiation. PMID: 25494542
    5. ARHGEF3 and RHOA are potential regulators of a number of genes in bone cells, with influences on ACTA2 evident in both osteoblast-like and osteoclast-like cells. PMID: 24840563
    6. XPLN is an endogenous inhibitor of mTORC2. PMID: 24043828
    7. the association between rs7646054 in ARHGEF3 and bone mineral density observed in Caucasians was not replicated in the chinese samples. PMID: 19727905
    8. a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC PMID: 12221096
    9. genetic variation in ARHGEF3 plays a role in the determination of bone density in Caucasian women. This data implicates the RhoGTPase-RhoGEF pathway in osteoporosis. PMID: 18499081

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 組織特異性：
    Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 683

    OMIM: 612115

    KEGG: hsa:50650

    STRING: 9606.ENSP00000341071

    UniGene: Hs.476402



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