在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ARC Antibody

ARC Antibody

  • 中文名稱：
    ARC兔多克隆抗體
  • 貨號：
    CSB-PA698018
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA698018(ARC Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA698018(ARC Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA698018(ARC Antibody) at dilution 1/597, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ARC
  • 別名：
    activity regulated cytoskeleton associated protein antibody; activity regulated gene 3.1 protein homolog antibody; Activity-regulated cytoskeleton-associated protein antibody; Activity-regulated gene 3.1 protein homolog antibody; Arc antibody; ARC/ARG3.1 antibody; ARC_HUMAN antibody; Arg 3.1 antibody; Arg3.1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ARC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory. Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1. In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.
  • 基因功能參考文獻：
    1. The ARC complex revealed association with verbal and total IQ in child. PMID: 28671113
    2. Study identified several rare mutations that reduced ARC expression in schizophrenia patients. Furthermore, DNA methylation of ARC in schizophrenia patients may be associated with a downregulation of ARC mRNA expression. These findings suggest that multiple rare ARC variants and DNA methylation of ARC might contribute to the pathogenesis of schizophrenia. PMID: 27464451
    3. missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc, disrupting Arc ubiquitination, and consequently Arc degradation. PMID: 27995769
    4. ARC confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways PMID: 26995091
    5. We tested whether ARC variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS). PMID: 26516611
    6. this is the first report associating an ARC SNP with schizophrenia and supports recent large-scale GWAS findings implicating the ARC complex in schizophrenia risk PMID: 26474411
    7. we propose that the peculiar characteristics of Arc protein, such as its optimal expression after ongoing experience or familiar behavior could explain how familiarization and recognition memories are stored and preserved in the mammalian brain--{REVIEW} PMID: 26380114
    8. mRNA levels of ARC and SGK1 did not differ significantly between the schizophrenia or control samples. PMID: 26038830
    9. Arc is a flexible multi-domain protein that exists in monomeric and oligomeric forms, compatible with a diverse, hub-like role in plasticity-related processes. PMID: 25748042
    10. Degradation of Arc by clathrin-localized Triad3A regulates the availability of synaptic AMPA receptors. PMID: 24945773
    11. we report a novel ARC single nucleotide polymorphism associated with a reduced risk of developing Alzheimer disease. PMID: 22622366
    12. analysis of dynamic, multifaceted control of Arc synthesis during mAchR signaling PMID: 22584581
    13. Strong fibrinogen and Abeta deposition is demonstrated in small- and medium-sized vessels, but not in large cerebral arteries, of 24-month-old transgenic arcAbeta mice. PMID: 22302811
    14. Arc Expression Is Increased in medial frontal cortex of patients with Alzheimer's Disease. PMID: 22036569
    15. Arc/MS2 mRNA assembles into particles that move independently, bidirectionally, and intermittently. These observations identify several phases of Arc mRNA movement that serve as potential points for regulating Arc mRNA localization. PMID: 17120280

    顯示更多

    收起更多

  • 亞細胞定位：
    Extracellular vesicle membrane; Lipid-anchor. Cell junction, synapse, postsynaptic cell membrane; Lipid-anchor. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Early endosome membrane. Cell projection, dendrite. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell projection, dendritic spine. Cytoplasmic vesicle, secretory vesicle, acrosome.
  • 蛋白家族：
    ARC/ARG3.1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 648

    OMIM: 612461

    KEGG: hsa:23237

    STRING: 9606.ENSP00000349022

    UniGene: Hs.40888



主站蜘蛛池模板： 国语少妇高潮对白在线| 国产av精品毛片一区二区三区| 天天做天天欢摸夜夜摸狠狠摸| 韩国国内大量揄拍精品视频| 国产热re99久久6国产精品首页 | 2019nv天堂香蕉在线观看| 亚洲精品一区二区三区婷婷月| 亚洲国产精品嫩草影院永久| 中文无码精品a∨在线| 亚洲日本va中文字幕久久| 性色av极品无码专区亚洲| 欧美99久久无码一区人妻a片| 成人免费午夜无码视频 | 日本牲交大片免费观看| 国产在线码观看超清无码视频| 久久久精品94久久精品| 国内精品九九久久精品| 精品人妻系列无码人妻免费视频 | 女性自慰网站免费观看w| av无码久久久久不卡网站蜜桃| 国产精品老热丝在线观看| 日本三级手机在线播放线观看| 午夜131美女爱做视频| 国产香蕉尹人在线观看视频| 亚洲精品乱码久久久久久日本| 国产偷伦视频片免费视频| 亚洲中文字幕a∨在线| 永久免费无码网站在线观看| 影音先锋在线资源无码| 国产成人免费无庶挡视频| 亚洲欧美日韩国产国产a| 三级4级全黄60分钟| 欧美亅性猛交内射| 中文字幕无线观看不卡网站| 久久国产色av| 久久视频在线视频| 老司机无码精品a| 亚洲成av 人片在线观看无码| 人人超碰人人爱超碰国产 | 国产av丝袜旗袍无码网站| 色偷偷av一区二区三区|