在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ARAF Antibody

ARAF Antibody

  • 中文名稱：
    ARAF兔多克隆抗體
  • 貨號：
    CSB-PA000918
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HeLa cells using A-Raf Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    A raf 1 antibody; A Raf proto oncogene serine/threonine protein kinase antibody; ARAF 1 antibody; Araf antibody; ARaf proto oncogene serine/threonine protein kinase antibody; ARAF_HUMAN antibody; ARAF1 antibody; Oncogene Araf1 antibody; Oncogene PKS2 antibody; PKS 2 antibody; PKS antibody; PKS2 antibody; Proto oncogene Pks antibody; Proto-oncogene A-Raf antibody; Proto-oncogene A-Raf-1 antibody; Proto-oncogene Pks antibody; RAFA 1 antibody; RAFA1 antibody; Ras binding protein DA Raf antibody; Serine/threonine-protein kinase A-Raf antibody; v raf murine sarcoma 3611 viral oncogene homolog antibody; v raf murine sarcoma 3611 viral oncogene homolog 1 antibody; v raf oncogene homolog 1 (murine sarcoma 3611 virus) antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human A-Raf around the non-phosphorylation site of Y302.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.; Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.
  • 基因功能參考文獻：
    1. The constitutive or induced re-localization of A-Raf to the plasma membrane compromises its ability to efficiently sequester and inactivate MST2, thus rendering cells susceptible to apoptosis PMID: 26891695
    2. This review discusses the regulation of A-Raf protein expression, and the roles of A-Raf in apoptosis and cancer, with a special focus on its role in resistance to Raf inhibitors. [review] PMID: 26508523
    3. analysis of FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma PMID: 25608663
    4. Aberrant expression of A-, B-, and C-RAF, and COT is frequent in PTC; increased expression of COT is correlated with recurrence of PTC. PMID: 25674762
    5. Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration. PMID: 25097033
    6. The study identifies somatic activating ARAF mutations in Langerhans cell histiocytosis. PMID: 24652991
    7. Galpha12-ARAF-ERK pathway stimulates RFFL transcription through the transcription factor c-Myc. PMID: 24114843
    8. show that Araf antagonizes mesendoderm induction and patterning activity of Nodal/Smad2 signals in vertebrate embryos by directly inhibiting Smad2 signalling PMID: 23591895
    9. study investigated role of ARAF in cancer cell signaling and examined the role of ARAF in mediating paradoxical activation of the MAPK pathway in cells treated with RAF inhibitors; ARAF seems to stabilize BRAF:CRAF complexes in cells treated with RAF inhibitors and regulate cell signaling in a subtle manner to ensure signaling efficiency PMID: 22926515
    10. Ras pathway activation via EGF treatment induced strong binding between B-Raf and C-Raf and a low level of binding between B-Raf and A-Raf. PMID: 23352452
    11. hnRNP H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. PMID: 20145135
    12. In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf. PMID: 11952167
    13. A-Raf kinase is negatively regulated by trihydrophobin 1 PMID: 14684750
    14. mutation analysis of the conserved regions in the ARAF gene in human colorectal adenocarcinoma PMID: 14688025
    15. A-Raf residues are identified that bind to specific phosphoinositides, possibly as a mechanism to localize the enzyme to particular membrane microdomains rich in these phospholipids. PMID: 15736953
    16. These data reveal that B-RAF is an important mediator of neuronal survival, migration, and dendrite formation and that A-RAF cannot fully compensate for these functions. PMID: 16980614
    17. Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites. PMID: 18662992
    18. A-Raf interacts with MEK1 and activates MEK1 by phosphorylation. PMID: 8621729

    顯示更多

    收起更多

  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily
  • 組織特異性：
    Predominantly in urogenital tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 646

    OMIM: 311010

    KEGG: hsa:369

    STRING: 9606.ENSP00000366244

    UniGene: Hs.446641



主站蜘蛛池模板： 亚洲精品久久久久久中文传媒| 欧美影视精品久久| 越南女子杂交内射bbwxz| 群交射精白浆视频| 欧美午夜精品一区二区三区电影 | 久久av高清无码| 亚洲欧美一区二区三区在线| 国产日韩制服丝袜第一页| 2021精品亚洲中文字幕| 日本免费一区二区三区视频观看| 欧美性受xxxx黑人xyx性爽| 极品美女在线观看免费直播| av无码久久久久不卡网站下载| 亚洲精品乱码久久久久久v| 国产精品亚洲专区无码牛牛| 麻花传媒剧国产mv高清播放| 婷婷综合缴情亚洲| 性色欲网站人妻丰满中文久久不卡| 国产精品欧美一区二区三区| 日韩高清成片免费视频| 久久精品一区二区av999| 国产精自产拍久久久久久蜜| 精品精品国产男人的天堂| 成人免费无码不卡毛片| 免费无码av一区二区三区| 人人妻人人爽人人做夜欢视频 | 久久精品无码一区二区app| 国产欧美日韩精品专区| 两口子交换真实刺激高潮| 高潮毛片无遮挡高清视频播放| 久久亚洲色www成人男男| 国产在线拍揄自揄拍无码视频| 久久无码人妻精品一区二区三区 | 中国浓毛少妇毛茸茸| 色8激情欧美成人久久综合电影| 国产精品日本亚洲777| 久久综合狠狠综合久久综合88 | 亚欧日韩欧美网站在线看| 国产亚洲精品久久久久蜜臀| 亚洲国产一卡2卡3卡4卡5公司 | av制服丝袜白丝国产网站|