在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ARAF Antibody, Biotin conjugated

  • 中文名稱:
    ARAF兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA01679D0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ARAF Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    A raf 1 antibody; A Raf proto oncogene serine/threonine protein kinase antibody; ARAF 1 antibody; Araf antibody; ARaf proto oncogene serine/threonine protein kinase antibody; ARAF_HUMAN antibody; ARAF1 antibody; Oncogene Araf1 antibody; Oncogene PKS2 antibody; PKS 2 antibody; PKS antibody; PKS2 antibody; Proto oncogene Pks antibody; Proto-oncogene A-Raf antibody; Proto-oncogene A-Raf-1 antibody; Proto-oncogene Pks antibody; RAFA 1 antibody; RAFA1 antibody; Ras binding protein DA Raf antibody; Serine/threonine-protein kinase A-Raf antibody; v raf murine sarcoma 3611 viral oncogene homolog antibody; v raf murine sarcoma 3611 viral oncogene homolog 1 antibody; v raf oncogene homolog 1 (murine sarcoma 3611 virus) antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Serine/threonine-protein kinase A-Raf protein (160-310AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.; Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.
  • 基因功能參考文獻:
    1. The constitutive or induced re-localization of A-Raf to the plasma membrane compromises its ability to efficiently sequester and inactivate MST2, thus rendering cells susceptible to apoptosis PMID: 26891695
    2. This review discusses the regulation of A-Raf protein expression, and the roles of A-Raf in apoptosis and cancer, with a special focus on its role in resistance to Raf inhibitors. [review] PMID: 26508523
    3. analysis of FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma PMID: 25608663
    4. Aberrant expression of A-, B-, and C-RAF, and COT is frequent in PTC; increased expression of COT is correlated with recurrence of PTC. PMID: 25674762
    5. Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration. PMID: 25097033
    6. The study identifies somatic activating ARAF mutations in Langerhans cell histiocytosis. PMID: 24652991
    7. Galpha12-ARAF-ERK pathway stimulates RFFL transcription through the transcription factor c-Myc. PMID: 24114843
    8. show that Araf antagonizes mesendoderm induction and patterning activity of Nodal/Smad2 signals in vertebrate embryos by directly inhibiting Smad2 signalling PMID: 23591895
    9. study investigated role of ARAF in cancer cell signaling and examined the role of ARAF in mediating paradoxical activation of the MAPK pathway in cells treated with RAF inhibitors; ARAF seems to stabilize BRAF:CRAF complexes in cells treated with RAF inhibitors and regulate cell signaling in a subtle manner to ensure signaling efficiency PMID: 22926515
    10. Ras pathway activation via EGF treatment induced strong binding between B-Raf and C-Raf and a low level of binding between B-Raf and A-Raf. PMID: 23352452
    11. hnRNP H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. PMID: 20145135
    12. In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf. PMID: 11952167
    13. A-Raf kinase is negatively regulated by trihydrophobin 1 PMID: 14684750
    14. mutation analysis of the conserved regions in the ARAF gene in human colorectal adenocarcinoma PMID: 14688025
    15. A-Raf residues are identified that bind to specific phosphoinositides, possibly as a mechanism to localize the enzyme to particular membrane microdomains rich in these phospholipids. PMID: 15736953
    16. These data reveal that B-RAF is an important mediator of neuronal survival, migration, and dendrite formation and that A-RAF cannot fully compensate for these functions. PMID: 16980614
    17. Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites. PMID: 18662992
    18. A-Raf interacts with MEK1 and activates MEK1 by phosphorylation. PMID: 8621729

    顯示更多

    收起更多

  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily
  • 組織特異性:
    Predominantly in urogenital tissues.
  • 數據庫鏈接:

    HGNC: 646

    OMIM: 311010

    KEGG: hsa:369

    STRING: 9606.ENSP00000366244

    UniGene: Hs.446641



主站蜘蛛池模板: 人与狗精品aa毛片| 亚洲中文字幕无码爆乳| 久久久无码中文字幕久...| 国产gv在线观看受被做哭| 国产午夜精品一区二区三区漫画| 国产精品久久久久影院| 亚洲va久久久噜噜噜久久4399| 欧美中文字幕无线码视频| 亚洲一区二区三区中文字幕在线| 久久精品无码精品免费专区| 国产亚洲精品久久久ai换| 午夜私人成年影院在线观看| 久热这里只有精品12| 欧美乱妇日本无乱码特黄大片| 奇米影视777四色狠狠| 无码国内精品久久人妻蜜桃| 久久99九九精品久久久久蜜桃| 国产suv精品一区二区62| 国产精品自在拍在线播放| 欧美午夜片欧美片在线观看| 久久国产亚洲高清观看| 久久亚洲一区二区三区四区| 亚洲一二三四2021不卡 | 国产精品无码久久久久久| 极品熟妇大蝴蝶20p| 92久久精品一区二区| 亚洲伊人久久大香线蕉| 久久综合给久久狠狠97色| 无套内谢孕妇毛片免费看看| 女邻居的大乳中文字幕| 日韩免费码中文在线观看| 日韩精品久久久久久免费| 99久久综合狠狠综合久久止| 真人做人60分钟啪啪免费看| 少妇精品揄拍高潮少妇| 国产xxx69麻豆国语对白| 亚洲伊人久久大香线蕉综合图片| 久久久国产精品无码一区二区| 4399理论片午午伦夜理片| 日韩免费特黄一二三区| 日韩av无码一区二区三区不卡毛片|