在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. APLF Antibody

APLF Antibody

  • 中文名稱：
    APLF兔多克隆抗體
  • 貨號(hào)：
    CSB-PA825036
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA825036(APLF Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA825036(APLF Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    APLF
  • 別名：
    2010301N04Rik antibody; AI452191 antibody; Aplf antibody; APLF_HUMAN antibody; Aprataxin and PNK-like factor antibody; Apurinic-apyrimidinic endonuclease APLF antibody; C2orf13 antibody; PNK and APTX like FHA protein antibody; PNK and APTX-like FHA domain-containing protein antibody; RGD1565557 antibody; XIP1 antibody; XRCC1 interacting protein 1 antibody; XRCC1-interacting protein 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Fusion protein of Human APLF
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ).
  • 基因功能參考文獻(xiàn)：
    1. characterization of the interaction of the APLF FHA domain with phosphorylated XRCC1 peptides PMID: 29059378
    2. These data suggest functional requirements for Ku and XRCC4 in APLF-dependent NHEJ and a unique role for Ku as a factor required to facilitate the nuclear retention of APLF. PMID: 23689425
    3. APLF promotes the assembly and activity of multi-protein Ku-DNA complexes containing all of the Non-homologous end joining (NHEJ) factors required for DNA ligation. PMID: 23178593
    4. Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease and can participate in DNA end joining in a biochemical system. PMID: 21885877
    5. only a positive association (OR=1.58, 95% CI 1.05-2.46, P=0.027) was obtained for XRCC1 (Arg280His PMID: 21414327
    6. APLF has a role in chromosomal DNA double-strand break repair. PMID: 21211721
    7. The poly(ADP-ribose)-regulated protein APLF as a DNA-damage-specific histone chaperone. PMID: 21211722
    8. The authors present solution structures of the two poly(ADP-ribose)-binding zinc finger modules of aprataxin and PNK-like factor (APLF), revealing a novel type of zinc finger. PMID: 20098424
    9. These data identify APLF as a novel component of the cellular response to DNA strand breaks in human cells. PMID: 17353262
    10. PALF is novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. PMID: 17396150
    11. APLF is an ATM target that is involved in nonhomologous end-joining and facilitates double-strand break repair, likely via interactions with Ku and XRCC4-DNA ligase IV. PMID: 18077224
    12. Study concludes that APLF can accumulate at sites of chromosomal damage via zinc finger-mediated binding to poly(ADP-ribose) and is a novel component of poly(ADP-ribose) signaling in mammalian cells. PMID: 18474613

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Chromosome. Cytoplasm, cytosol.
  • 蛋白家族：
    APLF family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28724

    OMIM: 611035

    KEGG: hsa:200558

    STRING: 9606.ENSP00000307004

    UniGene: Hs.720369



主站蜘蛛池模板： 久久er热在这里只有精品66| 在线精品动漫一区二区无码| 大香线蕉伊人精品超碰| 国产97人妻人人做人碰人人爽| 精品综合久久久久久97| 国产国产成人久久精品| 国产乱人伦av在线麻豆a| 日日碰狠狠添天天爽五月婷| 久久九九有精品国产尤物| 国产精品av在线| 国产精品白丝喷水在线观看| 人妻无码一区二区三区 tv| s级爆乳玩具酱国产vip皮裤| 在线无码免费的毛片视频| 国产草莓视频无码a在线观看| 国产精品亚洲欧美中字| 四川丰满少妇被弄到高潮| 国产手机在线精品| 毛片tv网站无套内射tv网站| 久久久喷潮一区二区三区| 男女啪啪抽搐呻吟高潮动态图| 在线成人爽a毛片免费软件| 无码 制服 丝袜 国产 另类| 天堂中文8资源在线8| 欧美成人va免费大片视频| 亚洲va在线va天堂xxxx| 伊人精品成人久久综合97 | 无码av波多野结衣久久| 中文字字幕在线中文无码| aa区一区二区三无码精片| 狂野欧美激情性xxxx在线观看| 亚洲人成图片小说网站| 国产乱子影视频上线免费观看| 10000部拍拍拍免费视频 | 亚洲 欧美 偷自乱 图片| 欧美肥熟妇xxxxx| 他用舌头给我高潮喷水在线 | 西西人体大胆午夜啪啪| 国产在线看片免费视频| 色哟哟最新在线观看入口| 少妇被粗大的猛烈进出视频|