在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. APLF Antibody

APLF Antibody

  • 中文名稱：
    APLF兔多克隆抗體
  • 貨號：
    CSB-PA008030
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HT-29 cells using APLF Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    APLF
  • 別名：
    2010301N04Rik antibody; AI452191 antibody; Aplf antibody; APLF_HUMAN antibody; Aprataxin and PNK-like factor antibody; Apurinic-apyrimidinic endonuclease APLF antibody; C2orf13 antibody; PNK and APTX like FHA protein antibody; PNK and APTX-like FHA domain-containing protein antibody; RGD1565557 antibody; XIP1 antibody; XRCC1 interacting protein 1 antibody; XRCC1-interacting protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human APLF around the non-phosphorylation site of S116.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ).
  • 基因功能參考文獻：
    1. characterization of the interaction of the APLF FHA domain with phosphorylated XRCC1 peptides PMID: 29059378
    2. These data suggest functional requirements for Ku and XRCC4 in APLF-dependent NHEJ and a unique role for Ku as a factor required to facilitate the nuclear retention of APLF. PMID: 23689425
    3. APLF promotes the assembly and activity of multi-protein Ku-DNA complexes containing all of the Non-homologous end joining (NHEJ) factors required for DNA ligation. PMID: 23178593
    4. Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease and can participate in DNA end joining in a biochemical system. PMID: 21885877
    5. only a positive association (OR=1.58, 95% CI 1.05-2.46, P=0.027) was obtained for XRCC1 (Arg280His PMID: 21414327
    6. APLF has a role in chromosomal DNA double-strand break repair. PMID: 21211721
    7. The poly(ADP-ribose)-regulated protein APLF as a DNA-damage-specific histone chaperone. PMID: 21211722
    8. The authors present solution structures of the two poly(ADP-ribose)-binding zinc finger modules of aprataxin and PNK-like factor (APLF), revealing a novel type of zinc finger. PMID: 20098424
    9. These data identify APLF as a novel component of the cellular response to DNA strand breaks in human cells. PMID: 17353262
    10. PALF is novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. PMID: 17396150
    11. APLF is an ATM target that is involved in nonhomologous end-joining and facilitates double-strand break repair, likely via interactions with Ku and XRCC4-DNA ligase IV. PMID: 18077224
    12. Study concludes that APLF can accumulate at sites of chromosomal damage via zinc finger-mediated binding to poly(ADP-ribose) and is a novel component of poly(ADP-ribose) signaling in mammalian cells. PMID: 18474613

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome. Cytoplasm, cytosol.
  • 蛋白家族：
    APLF family
  • 數據庫鏈接：

    HGNC: 28724

    OMIM: 611035

    KEGG: hsa:200558

    STRING: 9606.ENSP00000307004

    UniGene: Hs.720369



主站蜘蛛池模板： 欧美日韩人成视频在线播放| 国产98在线 | 日韩| 一出一进一爽一粗一大视频免费的| 国内精品久久久久影院免费| 国产精品亚洲专区无码影院| 顶级欧美熟妇高潮xxxxx| 妺妺窝人体色www看人体| 成人免费的视频| 亚洲精品日本一区二区三区 | 精品人妻无码一区二区三区| 丁香五月婷激情综合第九色| 成人亚洲欧美日韩在线观看| 中文字字幕在线成人av电影| 国模无码视频一区二区三区| 天堂а√在线官网| 成人影院yy111111在线| 肉体裸交137日本大胆摄影 | 久久国产超碰女女av| 欧美黑人乱大交| 色爱区综合五月激情| 51被公侵犯玩弄漂亮人妻| 亚洲精品国产成人精品软件| 亚洲a∨无码男人的天堂| 免费的很黄很污的视频| 国产福利日本一区二区三区| 日韩精品久久久免费观看| 国产精品白浆一区二小说| 成人午夜看黄在线尤物成人| 国语自产偷拍精品视频蜜芽| 99偷拍视频精品一区二区| 无遮无挡爽爽免费毛片| 国内外精品激情刺激在线| 狂野欧美激情性xxxx按摩| 国产精品久久国产三级国不卡顿| 国产精品日本一区二区在线播放| 午夜福利理论片高清在线| 国自产拍偷拍精品啪啪av| 日韩欧美在线综合网| 日韩av高清在线观看| 久久久国产精品va麻豆| 国产成人精品无码a区在线观看|